Trunk strength and function using the multidirectional reach distance in individuals with non-traumatic spinal cord injury

Gabison, Sharon; Verrier, Molly C.; Nadeau, Sylvie; Gagnon, Dany H.; Roy, Audrey; Flett, Heather

doi:10.1179/2045772314y.0000000246

Cited by 21 publications

(23 citation statements)

References 25 publications

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“…Further refinement of the trunk and abdomen testing paradigm that we created could include paraspinal EMG, and testing for artifacts from nearby structures. A clinical trunk score ( 68 ) and spirometry should be incorporated ( 15 , 162 , 163 ). Another approach to defining a level based on ICs might be to determine the level(s) above which IC spasms cannot be generated.…”

Section: Discussionmentioning

confidence: 99%

Neurophysiological Changes in the First Year After Cell Transplantation in Sub-acute Complete Paraplegia

et al. 2021

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Neurophysiological testing can provide quantitative information about motor, sensory, and autonomic system connectivity following spinal cord injury (SCI). The clinical examination may be insufficiently sensitive and specific to reveal evolving changes in neural circuits after severe injury. Neurophysiologic data may provide otherwise imperceptible circuit information that has rarely been acquired in biologics clinical trials in SCI. We reported a Phase 1 study of autologous purified Schwann cell suspension transplantation into the injury epicenter of participants with complete subacute thoracic SCI, observing no clinical improvements. Here, we report longitudinal electrophysiological assessments conducted during the trial. Six participants underwent neurophysiology screening pre-transplantation with three post-transplantation neurophysiological assessments, focused on the thoracoabdominal region and lower limbs, including MEPs, SSEPs, voluntarily triggered EMG, and changes in GSR. We found several notable signals not detectable by clinical exam. In all six participants, thoracoabdominal motor connectivity was detected below the clinically assigned neurological level defined by sensory preservation. Additionally, small voluntary activations of leg and foot muscles or positive lower extremity MEPs were detected in all participants. Voluntary EMG was most sensitive to detect leg motor function. The recorded MEP amplitudes and latencies indicated a more caudal thoracic level above which amplitude recovery over time was observed. In contrast, further below, amplitudes showed less improvement, and latencies were increased. Intercostal spasms observed with EMG may also indicate this thoracic “motor level.” Galvanic skin testing revealed autonomic dysfunction in the hands above the injury levels. As an open-label study, we can establish no clear link between these observations and cell transplantation. This neurophysiological characterization may be of value to detect therapeutic effects in future controlled studies.

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Section: Discussionmentioning

confidence: 99%

Neurophysiological Changes in the First Year After Cell Transplantation in Sub-acute Complete Paraplegia

et al. 2021

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“…Improvements in physical function have also been shown to positively impact health behavior and overall QoL as demonstrated by Ginis et al 33 Individuals who are able to reach forward further, as captured by the mFRT, also demonstrate improved seated balance and postural control. 34,35 Ability to reach forward could potentially help conserve energy with everyday tasks, perhaps enabling those with SCI to have increased participation in exercise. Recently Lundström et al, found that aging individuals with SCI had decreased participation in planned exercise secondary to variables including spasticity and decreased strength.…”

Section: Discussionmentioning

confidence: 99%

Community exercise programing and its potential influence on quality of life and functional reach for individuals with spinal cord injury

Sliwinski

Akselrad

Alla

et al. 2018

The Journal of Spinal Cord Medicine

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Context/Objective: After an individual with a Spinal Cord Injury (SCI) participates in the initial rehabilitation process, they often experience limited access to physical therapy services and other fitness activities. The purpose of this study was to examine previously collected data for changes in quality of life (QoL) and functional reach in individuals with SCI following an 8-week community exercise program. Design: Secondary analysis of previously collected data. Setting: Community-based exercise program. Participants: Twenty-two participants with an average of 9 years post-SCI, both complete and incomplete injuries, and injury levels ranging from C2 to L5. Interventions: Participants completed an 8-week program, once per week for 4 hours that included a four-station circuit of resistance training, aerobic exercise, trunk stability, and education. Outcome Measures: Physical function was measured using the modified Functional Reach Test (mFRT). QoL was measured with the Life Satisfaction Questionnaire-9 (LiSAT-9). Results: The mFRT improved by 2 inches (±7.04) P < 0.001 and QoL improved as well, P < 0.001. Conclusion: The findings of this study are consistent with the hypothesis that a supervised post-rehabilitation community exercise program, like Spinal Mobility, may positively impact the QoL and functional reach in individuals with SCI.

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“…Patients with NTSCI state minority among the spinal cord population. NTSCI can be a consequence of multiple etiologies including infection, spinal stenosis, vascular impairment, transverse myelitis, syringomyelia, malignant and benign tumors [ 2 ]. Traumatic spinal cord injury results from contusion, compression, and stretch of the spinal cord.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Olfactory Ensheathing Cells and Mesenchymal Stem Cells in Spinal Cord Injuries

Zadroga

Jezierska-Woźniak

Czarzasta

et al. 2017

Stem Cells International

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Spinal cord injury (SCI) is a devastating neurological condition that affects individuals worldwide, significantly reducing quality of life, for both patients and their families. In recent years there has been a growing interest in cell therapy potential in the context of spinal cord injuries. The present review aims to discuss and compare the restorative approaches based on the current knowledge, available spinal cord restorative cell therapies, and use of selected cell types. However, treatment options for spinal cord injury are limited, but rehabilitation and experimental technologies have been found to help maintain or improve remaining nerve function in some cases. Mesenchymal stem cells as well as olfactory ensheathing cells seem to show therapeutic impact on damaged spinal cord and might be useful in neuroregeneration. Recent research in animal models and first human trials give patients with spinal cord injuries hope for recovery.

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Trunk strength and function using the multidirectional reach distance in individuals with non-traumatic spinal cord injury

Cited by 21 publications

References 25 publications

Neurophysiological Changes in the First Year After Cell Transplantation in Sub-acute Complete Paraplegia

Neurophysiological Changes in the First Year After Cell Transplantation in Sub-acute Complete Paraplegia

Community exercise programing and its potential influence on quality of life and functional reach for individuals with spinal cord injury

Therapeutic Potential of Olfactory Ensheathing Cells and Mesenchymal Stem Cells in Spinal Cord Injuries

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