This is a study of whether people's ways of coping and thinking patterns will change when dealing with their physical or psychological trauma and difficulties after experiencing cultures that are completely different from their native cultures (including cultural integration, acculturation, and immigration). There have been many articles discussing this topic, and the results may provide a clearer picture of the psychological changes in people and may even provide ideas for future medical treatments as well as research in the humanities and social sciences. This article discusses and draws conclusions about changes in the way people and immigrants in four of the world's geographic regions (i.e., Europe and North America, Asia, Africa, and Latin America) deal with and think about issues, and therefore does not necessarily mean that people and immigrants in other geographic regions will be completely in line with the results of this discussion. The study reveals how cultural integration, acculturation, and immigration can alter individuals' cognitive and emotional reactions to adversities. The findings not only enhance the current research in cultural psychology and mental well-being but also highlight the importance of personalized approaches that honor cultural nuances. By clarifying the cultural structures that influence individuals' perceptions and coping strategies, this research offers valuable insights that can guide future mental health interventions, policy formulations, and cross-cultural collaborations.