Trypanocidal activity of extracts and compounds from the stem bark of Anogeissus leiocarpus and Terminalia avicennoides

Shuaibu, Mohammed Nasir; Wuyep, P. A.; Yanagi, Tetsuo; Hirayama, Kenji; Ichinose, Akitoyo; Tanaka, Takashi; Kouno, Isao

doi:10.1007/s00436-007-0815-1

Cited by 69 publications

(42 citation statements)

References 28 publications

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“…This is the case of the powder of the leaves or bark of Terminalia avicennioides and Ceiba pentendra by maceration by African farmers [22], the bark of Anogeissus leiocarpus [23] and Diospyros malabarica in Bangladesh [24]. In Cameroon, Ngantchou and Nono [25] identified the.…”

Section: Discussionmentioning

confidence: 99%

Constraints of Ruminant Rearing and Ethno-veterinary Practice Against African Animal Trypanosomosis in the Pastoral Area of Gaongho in Burkina Faso

André¹

2017

AVS

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Abstract:In rural area of Burkina Faso, health management of domestic animals is a constant concern for low-income farmers. In this context, an ethno-veterinary survey was conducted among 62 farmers of ruminant in the pastoral area of Gaongho in Bazèga province to understand the rearing practice, to identify the main constraints of and the practices used against African trypanosomosis. For this, data were collected between March to June 2014 using a structured questionnaire and analyzed by descriptive statistics such as mean, frequency and percentages. The results showed that respondents were 48.3% literate and mainly of Fulani ethnic with an average age of 45 years. The main constraints of ruminant rearing for farmers are diseases (86.2%), particularly African Animal Trypanosomosis which is the most dominant (96.7%). To control this pathology, farmers practice modern (100%) and traditional (35.4%) medicine. Seventeen traditional herbal remedies are used to control trypanosomosis of ruminants in the area. Their modes of preparation and administration to ruminants are described according to surveyed farmers.

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Section: Discussionmentioning

confidence: 99%

Constraints of Ruminant Rearing and Ethno-veterinary Practice Against African Animal Trypanosomosis in the Pastoral Area of Gaongho in Burkina Faso

André¹

2017

AVS

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“…and Perr. (Combretaceae) is widely used for some of its properties such as pest-destroying (Okpekon et al 2004), trypanocides (Shuaibu et al 2008) and antifungal (Batawila et al 2005). Recently, antibacterial activity of terpenoidal fractions from A. leiocarpus have been shown (Mann et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Endothelium-independent and endothelium-dependent vasorelaxation by a dichloromethane fraction from Anogeissus leiocarpus (dc) guill. Et Perr. (combretaceae): possible involvement of cyclic nucleotide phosphodiesterase inhibition

Belemnaba¹,

Ouédraogo²,

Auger³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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Many traditional medicinal herbs from Burkina Faso are used to treat arterial hypertension (HTA). Among them, Anogeissus leiocarpus (A. Leiocarpus) which is well known and widely used in Burkina traditional medicine. Herein we assess the effects of dichloromethane fraction from A. leiocarpus stem bark (ALF), selected as the most active on cyclic nucleotide phosphodiesterases (PDEs) and characterized its specificity towards purified vascular PDE1 to PDE5 isoenzymes and study its effects on a vascular model. ALF potently and preferentially inhibits (IC 50 =1.6 ± 0.6 µg/mL) the calmodulindependent phosphodiesterase PDE1, being mainly present in vascular smooth muscle and preferentially hydrolyses cGMP. In the same range (IC 50 =2.8 ±0.2 µg/ml) ALF inhibits PDE2, a cGMP-activated enzyme that is only present in endothelial cells and hydrolyses both cAMP and cGMP. PDE5, which specifically hydrolyses cGMP and which mainly contributes to cGMP hydrolysis is also potently inhibited by ALF (IC 50 =7.6±3.5 µg/ml). The potencies of ALF on cAMP hydrolyzing isoenzymes was lesser, being more effective on PDE4 (IC 50 = 17.6±3.5 µg/ml) than on PDE3 (60.9 ± 1.8 µg/ml). Since the major effect of ALF were against cGMP hydrolysis and since cGMP is implicated in endothelium-dependent relaxation, the endotheliumdependent vasorelaxation was studied on isolated porcine coronary arteries rings pre-contracted with U46619. The endothelium-dependent vasorelaxation is significantly inhibited by N ω -nitro-L-arginine (LNA 300 µmol/L, an inhibitor of endothelial NO synthase), but not affected by charybdotoxin (CTX, 100nM) plus apamin (APA, 100nM) (two inhibitors of EDHF-mediated responses). The combination of 4-aminopyridine (4-AP, 1 mmol/L, inhibitor of voltage-dependent potassium channels, K v ) plus baryum (Ba 2+ , 30 µmol/L, inhibitor of the potassium channels with entering correction, K ir ) plus ouabain (3 µmol/L, inhibitor of ATPase Na + /K + channels) partially inhibits endothelium-independent vasorelaxant effect. This endothelium-independent relaxant effect was also sensitive to combination of 1H-[1,2,4]-oxadiazole-[4,3-α]-quinoxalin-1-one (ODQ, 10 µM, soluble guanylyl cyclase inhibitor) and N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide dihydrochloride (H89, 100 nM, Protein Kinase A inhibitor). Taken together, these results indicate that ALF is a powerful vasodilator modulated by the formation of NO from endothelium, but also act by directly relaxing the vascular smooth muscle cells, by inhibiting cGMP hydrolyzing PDEs (PDE1, PDE2 and PDE5) and to a lesser extend on cAMP degradation (PDE3 and PDE4), cAMP and cGMP being second messengers involved in vascular relaxation.

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“…Compounds with antimycobacterial activities have been isolated from plants [11]. Some compounds earlier isolated from T. avicennioides are hydrolysable tannins that indicated antitrypanosomal activity [12]. However, extensive array of triterpenes has been reported to exhibit diverse biological activities such as anti-HIV-1 activity [13], antimycobacterial activity [11], antifungal and antimicrobial [14,15]; antiulcerogenic, anti-inflammatory, fibrocystic, antipyretic, analgesic, larvicidal, and antiedematous activities [16,17].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Elucidation of Three Triterpenoids and Its Antimycobacterial Activty of Terminalia Avicennioides

Mann¹,

Ibrahim²,

Oyewale³

et al. 2012

AJOC

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Terminalia avicennioides Guill. & Perr. (Combretaceae) has been traditionally used as traditional medicine for centuries in Nupeland, North Central Nigeria for the treatment of respiratory diseases such as tuberculosis and cough. This study evaluates the in vitro antimycobacterial activities of the isolated compounds in order to support the therapeutic use of T. avicennioides for treating these infectious diseases. Chemical investigation by bioassay-guided fractionation led to the isolation of three triterpenoids namely, arjunolic acid (1), α-amyrin (2) and 2, 3, 23-trihydroxylolean-12-ene (3). Among them, arjunolic acid manifested the most potent antimycobacterial activity against a strain of Mycobacterium bovis (BCG). Structure elucidation of the isolated compounds were based primarily on the analysis of 1-D and 2-D NMR spectral data including HMQC, HMBC, COSY and NOESY correlations, as well as comparison with reported authentic data of arjunolic acid, α-amyrin and 2, 3, 23-trihydroxylolean-12-ene. To the best of our knowledge, this is the first time these compounds (1-3) are reported from this plant. The present result further confirms the value of ethnopharmacological investigations into traditional herbs for leads for potential drug development.

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Trypanocidal activity of extracts and compounds from the stem bark of Anogeissus leiocarpus and Terminalia avicennoides

Cited by 69 publications

References 28 publications

Constraints of Ruminant Rearing and Ethno-veterinary Practice Against African Animal Trypanosomosis in the Pastoral Area of Gaongho in Burkina Faso

Constraints of Ruminant Rearing and Ethno-veterinary Practice Against African Animal Trypanosomosis in the Pastoral Area of Gaongho in Burkina Faso

Endothelium-independent and endothelium-dependent vasorelaxation by a dichloromethane fraction from <i>Anogeissus leiocarpus</i> (dc) <i>guill</i>. Et <i>Perr. (combretaceae)</i>: possible involvement of cyclic nucleotide phosphodiesterase inhibition

Isolation and Elucidation of Three Triterpenoids and Its<b> Antimycobacterial </b><b>Activty </b>of Terminalia Avicennioides

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