2008
DOI: 10.1016/j.phytochem.2008.04.002
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Trypanocidal structure–activity relationship for cis- and trans-methylpluviatolide

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Cited by 14 publications
(2 citation statements)
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“…Only the (-) enantiomer was active and despite being inactive the (+) enantiomer acted as an antagonistic competitor. In addition, at the evaluated concentrations trans-methylpluviatolide displayed low toxicity, and neither inhibited gGAPDH activity nor hindered peroxide and NO production [377].…”
Section: Glyceraldehyde-3-phosphate Dehydrogenase (Gapdh)mentioning
confidence: 86%
“…Only the (-) enantiomer was active and despite being inactive the (+) enantiomer acted as an antagonistic competitor. In addition, at the evaluated concentrations trans-methylpluviatolide displayed low toxicity, and neither inhibited gGAPDH activity nor hindered peroxide and NO production [377].…”
Section: Glyceraldehyde-3-phosphate Dehydrogenase (Gapdh)mentioning
confidence: 86%
“…Lignans and neolignans are biosynthetically generated from phenylpropanoids, depending on the ways they are linked 1 , which present a conspicuous chemical diversity and have multifarious clinical pharmacology activities 2 . In nature, lignans with chiral carbon atoms are usually composed of one enantiomer or of several stereoisomers with different amount, so they present optical activities in general 3 4 . In the past decades, the enantioseparation and absolute configurations of natural enantiomeric lignans and neolignans have attracted the attention of researchers around the world, with the aid of application of chromatographic enantioseparation, single-crystal X-ray diffraction, electronic circular dichroism (ECD) techniques 5 6 7 8 .…”
mentioning
confidence: 99%