Trypanosoma brucei: Infection in murine diabetes

Amole, Babatunde O.; Wittner, Murray; Hewlett, Dial; Tanowitz, Herbert B.

doi:10.1016/0014-4894(85)90040-2

Cited by 13 publications

(8 citation statements)

References 22 publications

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“…Interestingly, our previous studies indicated that when mice with chemically induced diabetes are infected with T. cruzi, they have a higher parasitemia and mortality (9). The same observation is seen when diabetic db/db mice are infected (9,10). The underlying reasons for these phenomena are unknown.…”

mentioning

confidence: 48%

The Adipocyte as an Important Target Cell for Trypanosoma cruzi Infection

Combs¹,

Nagajyothi²,

Mukherjee³

et al. 2005

Journal of Biological Chemistry

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183

240

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Adipose tissue plays an active role in normal metabolic homeostasis as well as in the development of human disease. Beyond its obvious role as a depot for triglycerides, adipose tissue controls energy expenditure through secretion of several factors. Little attention has been given to the role of adipocytes in the pathogenesis of Chagas disease and the associated metabolic alterations. Our previous studies have indicated that hyperglycemia significantly increases parasitemia and mortality in mice infected with Trypanosoma cruzi. We determined the consequences of adipocyte infection in vitro and in vivo. Cultured 3T3-L1 adipocytes can be infected with high efficiency. Electron micrographs of infected cells revealed a large number of intracellular parasites that cluster around lipid droplets. Furthermore, infected adipocytes exhibited changes in expression levels of a number of different adipocyte-specific or adipocyte-enriched proteins. The adipocyte is therefore an important target cell during acute Chagas disease. Infection of adipocytes by T. cruzi profoundly influences the pattern of adipokines. During chronic infection, adipocytes may represent an important long-term reservoir for parasites from which relapse of infection can occur. We have demonstrated that acute infection has a unique metabolic profile with a high degree of local inflammation in adipose tissue, hypoadiponectinemia, hypoglycemia, and hypoinsulinemia but with relatively normal glucose disposal during an oral glucose tolerance test.

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mentioning

confidence: 48%

The Adipocyte as an Important Target Cell for Trypanosoma cruzi Infection

Combs¹,

Nagajyothi²,

Mukherjee³

et al. 2005

Journal of Biological Chemistry

Self Cite

183

240

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“…Recent studies demonstrated that T. cruzi -infected mice fed a high fat diet displayed a reduction in parasitemia and in myocardial pathology, associated with an increase in parasite load in WAT, suggesting that WAT acts as a ‘sponge’ for the parasite and perhaps protects the heart from an increased parasite load [50,51]. In contrast, T. cruzi infection of obese and diabetic leptin-receptor deficient mice db/db mice lead to increased mortality compared with lean genetically modified db/db mice [52].…”

Section: Clinical Relevance and Drug Treatmentmentioning

confidence: 99%

“…As far as we know, no epidemiological study has been undertaken in patients with HAT to assess whether the number or severity of HAT cases is correlated with body mass index prior to infection. In mice, a T. brucei infection in obese and diabetic leptin-receptor deficient mice ( db/db ) resulted in decreased mortality compared to wild-type, suggesting a protective role of AT [51]. Other mouse mutants, drugs and diets need to be tested in infection mouse models to understand if there is a causal relationship between adipose tissue mass and infectivity.…”

Section: Clinical Relevance and Drug Treatmentmentioning

confidence: 99%

Adipose Tissue: A Safe Haven for Parasites?

Tanowitz

Scherer

Mota

et al. 2017

Trends in Parasitology

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Adipose tissue (AT) is no longer regarded as an inert lipid storage, but as an important central regulator in energy homeostasis and in immunity. Three parasite species are uniquely associated with AT during part of their life cycle: Trypanosoma cruzi, the causative agent of Chagas disease, Trypanosoma brucei, the cause of African sleeping sickness and Plasmodium spp, the cause of malaria. In the AT, T. cruzi resides inside adipocytes, T. brucei is found in the interstitial spaces between adipocytes, while Plasmodium spp. infect red blood cells that may adhere to the blood vessels supplying AT. We will discuss how each parasite species adapts to this tissue environment and what the implications are for pathogenesis, clinical manifestations and therapy.

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“…Adipose tissue can host T. cruzi for decades, protecting the infected from Chagas disease progression to cardiovascular death (Ferreira et al, 2011; Nagajyothi et al, 2012). Interestingly, Chagas disease increases the incidence of hyperglycemia in human correlation studies and, experimentally, hyperglycemic mice harbor increased parasitic loads and exhibit increased mortality upon T. cruzi infection (Amole et al, 1985; Tanowitz et al, 1988). Conversely, T. cruzi infection into wild-type mice induced hypoglycemia through pancreatic inflammation (Combs et al, 2005; Nagajyothi et al, 2013).…”

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confidence: 99%

The cell biology of fat expansion

Rutkowski

Stern

Scherer

2015

Journal of Cell Biology

462

404

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Adipose tissue is a complex, multicellular organ that profoundly influences the function of nearly all other organ systems through its diverse metabolite and adipokine secretome. Adipocytes are the primary cell type of adipose tissue and play a key role in maintaining energy homeostasis. The efficiency with which adipose tissue responds to whole-body energetic demands reflects the ability of adipocytes to adapt to an altered nutrient environment, and has profound systemic implications. Deciphering adipocyte cell biology is an important component of understanding how the aberrant physiology of expanding adipose tissue contributes to the metabolic dysregulation associated with obesity.

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Trypanosoma brucei: Infection in murine diabetes

Cited by 13 publications

References 22 publications

The Adipocyte as an Important Target Cell for Trypanosoma cruzi Infection

The Adipocyte as an Important Target Cell for Trypanosoma cruzi Infection

Adipose Tissue: A Safe Haven for Parasites?

The cell biology of fat expansion

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