Trypanosoma cruzi infection induces proliferation and impairs migration of a human breast cancer cell line

Silveira, Anna Clara Azevedo; Oliveira, Rayane Cristina de; Rodrigues, Cassiano Costa; Teixeira, Samuel Cota; Borges, Bruna Cristina; Silva, Cláudio Vieira da

doi:10.1016/j.exppara.2022.108443

Cited by 6 publications

(2 citation statements)

References 36 publications

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“…This preliminary result confirmed the anti-tumorigenesis effect of T. cruzi . Additionally, T. cruzi displayed a preference for invading the MDA-MB-231 breast cancer cell line, impacting the proliferation and migration of tumor cells, ultimately leading to the early lysis and death of these cells in a triple-negative breast cancer cell invasion assay ( Azevedo Silveira et al., 2023 ).…”

Section: T Cruzimentioning

confidence: 99%

A novel enemy of cancer: recent investigations into protozoan anti-tumor properties

Zheng,

Lu,

Zhou

et al. 2024

Front. Cell. Infect. Microbiol.

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Cancer remains a significant global health issue, despite advances in screening and treatment. While existing tumor treatment protocols such as surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy have proven effective in enhancing the prognosis for some patients, these treatments do not benefit all patients. Consequently, certain types of cancer continue to exhibit a relatively low 5-year survival rate. Therefore, the pursuit of novel tumor intervention strategies may help improve the current effectiveness of tumor treatment. Over the past few decades, numerous species of protozoa and their components have exhibited anti-tumor potential via immune and non-immune mechanisms. This discovery introduces a new research direction for the development of new and effective cancer treatments. Through in vitro experiments and studies involving tumor-bearing mice, the anti-tumor ability of Toxoplasma gondii, Plasmodium, Trypanosoma cruzi, and other protozoa have unveiled diverse mechanisms by which protozoa combat cancer, demonstrating encouraging prospects for their application. In this review, we summarize the anti-tumor ability and anti-tumor mechanisms of various protozoa and explore the potential for their clinical development and application.

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Section: T Cruzimentioning

confidence: 99%

A novel enemy of cancer: recent investigations into protozoan anti-tumor properties

Zheng,

Lu,

Zhou

et al. 2024

Front. Cell. Infect. Microbiol.

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show abstract

“…Similarly, treatment with recombinant P21 (rP21) arrested the cell cycle of the neoplastic cell line MDA-MB-231 in the G1 phase but had no such effect on the non-tumor cell line MCF-10A (Borges et al, 2020). On the contrary, conflicting data suggest that T. cruzi infection may promote proliferation in tumor cells (Azevedo Silveira et al, 2023). Moreover, T. cruzi infection has been shown to induce proliferation in a trophoblastic cell line and in hepatic epithelial cells through the activation of the ERK1/2 MAPK pathway (Bouzahzah et al, 2006;Droguett et al, 2017).…”

Section: Sustaining Of Proliferative Signalingmentioning

confidence: 99%

Trypanosoma cruzi, Chagas disease and cancer: putting together the pieces of a complex puzzle

Kaufman,

Farré,

Biscari

et al. 2023

Front. Cell Dev. Biol.

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Considering the extensive and widespread impact on individuals, cancer can presently be categorized as a pandemic. In many instances, the development of tumors has been linked to endemic microbe infections. Among parasitic infections, Trypanosoma cruzi stands out as one of the most extensively discussed protozoans in the literature that explores the association between diseases of parasite origin and cancer. However, the effective association remains an unsolved paradox. Both the parasite, along with protozoan-derived molecules, and the associated antiparasitic immune response can induce alterations in various host cell pathways, leading to modifications in cell cycle, metabolism, glycosylation, DNA mutations, or changes in neuronal signaling. Furthermore, the presence of the parasite can trigger cell death or a senescent phenotype and modulate the immune system, the metastatic cascade, and the formation of new blood vessels. The interaction among the parasite (and its molecules), the host, and cancer undoubtedly encompasses various mechanisms that operate differentially depending on the context. Remarkably, contrary to expectations, the evidence tilts the balance toward inhibiting tumor growth or resisting tumor development. This effect is primarily observed in malignant cells, rather than normal cells, indicating a selective or specific component. Nevertheless, nonspecific bystander mechanisms, such as T. cruzi’s adjuvancy or the presence of proinflammatory cytokines, may also play a significant role in this phenomenon. This work aims to elucidate this complex scenario by synthesizing the main findings presented in the literature and by proposing new questions and answers, thereby adding pieces to this challenging puzzle.

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Antitumor Effect Induced by Protozoa and Helminth Infections: Current Trends and Future Perspectives

García López,

González Cerón,

Torrel Pajares

2024

Pathogens Associated With the Development of Cancer in Humans

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Trypanosoma cruzi infection induces proliferation and impairs migration of a human breast cancer cell line

Cited by 6 publications

References 36 publications

A novel enemy of cancer: recent investigations into protozoan anti-tumor properties

A novel enemy of cancer: recent investigations into protozoan anti-tumor properties

Trypanosoma cruzi, Chagas disease and cancer: putting together the pieces of a complex puzzle

Antitumor Effect Induced by Protozoa and Helminth Infections: Current Trends and Future Perspectives

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