Trypanosoma cruzi: Mechanisms of intracellular calcium homeostasis

Oz, Helieh S.; Wittner, Murray; Tanowitz, Herbert B.; Bilezikian, John P.; Saxon, Maya; Morris, Stephen A.

doi:10.1016/0014-4894(92)90201-k

Cited by 21 publications

(11 citation statements)

References 15 publications

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“…This confirms the results of Oz et al (1992) for T. cruzi epimastigotes. This study found evidence for the existence of a Na + /K + ATPase exchanger upon adding ouabain to the extracellular medium.…”

Section: In Verosupporting

confidence: 93%

“…In T. cruzi, Frasch et al (1978) demonstrated the absence of any activity of this ATPase in the subcellular fractions of epimastigote forms by treating these fractions with a specific inhibitor. Later, Oz et al(1992) reported that ouabain added to the extracellular medium showed the presence of Na + /K + ATPase in complete epimastigote forms of T. cruzi.…”

Section: Introductionmentioning

confidence: 98%

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Ion regulation in the different life stages of Trypanosoma cruzi

Gil

Soler

Azzouz

et al. 2003

Parasitology Research

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Different ion and pH regulation mechanisms have been detected in the three main life stages of Trypanosoma cruzi: epimastigote, metacyclic trypomastigote and amastigote. Treatment with amiloride showed that the Na(+)/H(+) exchanger participated in all three forms. The Na(+)/K(+) ATPase exchanger appeared to be more active in the epimastigote than in the other forms. V-H(+)-ATPase inhibitors revealed the activity of this regulatory mechanism in the amastigote and epimastigote forms, while treatment with oligomycin only affected the amastigotes. The HCO(-)(3)/Cl(-) exchanger was found in all stages as well as in the intracellular pH-regulatory mechanism after abrupt basification. We deduce that ion regulation in T. cruzi is a complex process and depends upon the precise stage of the cell cycle of the parasite. It would seem to be an important mechanism, allowing the parasite to adapt to the changing environmental conditions within which it develops.

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Section: In Verosupporting

confidence: 93%

Section: Introductionmentioning

confidence: 98%

Ion regulation in the different life stages of Trypanosoma cruzi

Gil

Soler

Azzouz

et al. 2003

Parasitology Research

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“…Moreover, these results and those Ϫ9 M 125 I␣-BgTx for 2 h and washed, air-dried, and exposed to a sensitive film as described under Materials and Methods; after that, radioautographs were scanned and analyzed. (29) reported that verapamil and isradipine inhibit Ca 2ϩ uptake in T. cruzi epimastigote forms thus suggesting the existence of a certain type of channel.…”

Section: Discussionmentioning

confidence: 98%

Binding of Nicotinic Ligands to and Nicotine-Induced Calcium Signaling in Trypanosoma cruzi

Bollo

Venera

Bonino

et al. 2001

Biochemical and Biophysical Research Communications

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“…Another potential second messenger in this parasite is calcium. Cytosolic calcium concentrations ranging from 60 to 150 nM are maintained despite extracellular calcium concentrations of 5 mM (188). The presence of active sequestration processes in the endoplasmic reticulum and mitochondria with similarities to processes observed in higher eukaryotic organisms has been documented (275).…”

Section: Introductionmentioning

confidence: 99%

Chagas' disease

et al. 1992

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Chagas' disease, caused by Trypanosoma cruzi, is an important cause of morbidity in many countries in Latin America. The important modes of transmission are by the bite of the reduviid bug and blood transfusion. The organism exists in three morphological forms: trypomastigotes, amastigotes, and epimastigotes. The mechanism of transformation and differentiation is currently being explored, and signal transduction pathways of the parasites may be involved in this process. Parasite adherence to and invasion of host cells is a complex process involving complement, phospholipase, penetrin, neuraminidase, and hemolysin. Two clinical forms of the disease are recognized, acute and chronic. During the acute stage pathological damage is related to the presence of the parasite, whereas in the chronic stage few parasites are found. In recent years the roles of tumor necrosis factor, gamma interferon, and the interleukins in the pathogenesis of this infection have been reported. The common manifestations of chronic cardiomyopathy are arrhythmias and thromboembolic events. Autoimmune, neurogenic, and microvascular factors may be important in the pathogenesis of the cardiomyopathy. The gastrointestinal tract is another important target, and "mega syndromes" are common manifestations. The diagnosis and treatment of this infection are active areas of investigation. New serological and molecular biological techniques have improved the diagnosis of chronic infection. Exacerbations of T. cruzi infection have been reported for patients receiving immuno-suppressive therapy and for those with AIDS.

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Trypanosoma cruzi: Mechanisms of intracellular calcium homeostasis

Cited by 21 publications

References 15 publications

Ion regulation in the different life stages of Trypanosoma cruzi

Ion regulation in the different life stages of Trypanosoma cruzi

Binding of Nicotinic Ligands to and Nicotine-Induced Calcium Signaling in Trypanosoma cruzi

Chagas' disease

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