Trypanosoma cruzi Tc24 Antigen Expressed and Orally Delivered by Schizochytrium sp. Microalga is Immunogenic in Mice

Ramos‐Vega, Abel; Monreal‐Escalante, Elizabeth; Rosales‐Mendoza, Sergio; Bañuelos-Hernández, Bernardo; Dumonteil, Eric; Angulo, Carlos

doi:10.1007/s12033-023-00763-6

Cited by 3 publications

(1 citation statement)

References 74 publications

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“…[16][17][18][19][20] Gene engineered microalgae have been tested in protein drug development [21] and edible vaccine production. [22][23][24] Many strains of microalgae are rich in vitamins, antioxidants, proteins, and lipids and low in carbohydrates therefore they are considered as healthy food compounds. [25,26] On the global scale, microalgae might help to feed the growing human population, [27] requiring less land for production than common crops or animals [28,29] and can be grown offshore.…”

Section: Introductionmentioning

confidence: 99%

Recent advances and fundamentals of microalgae cultivation technology

Rozenberg,

Sorokin,

Mukhambetova

et al. 2024

Biotechnology Journal

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Microalgae are considered to be a promising group of organisms for fuel production, waste processing, pharmaceutical applications, and as a source of food components. Unicellular algae are worth being considered because of their capacity to produce comparatively large amounts of lipids, proteins, and vitamins while requiring little room for growth. They can also grow on waste and fix CO2 and nitrogen compounds. However, production costs limit the industrial use of microalgae to the most profitable applications including micronutrient production and fish farming. Therefore, novel microalgae based technologies require an increase of the production efficiencies or values. Here we review the recent studies focused on getting strains with novel characteristics or cultivating techniques that improve production's robustness or efficiency and categorize these findings according to the fundamental factors that determine microalgae growth. Improvements of light and nutrient delivery, as well as other aspects of photobioreactor design, have shown the highest average increase in productivity. Other methods, such as an improvement of phosphorus or CO2 fixation and temperature adaptation have been found to be less effective. Furthermore, interactions with particular bacteria may promote the growth of microalgae, although bacterial and grazer contaminations must be managed to avoid culture failure. The competitiveness of the algal products will increase if these discoveries are applied to industrial settings.

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Section: Introductionmentioning

confidence: 99%

Recent advances and fundamentals of microalgae cultivation technology

Rozenberg,

Sorokin,

Mukhambetova

et al. 2024

Biotechnology Journal

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Natural and recombinant bioactive compounds from Schizochytrium sp.: Recent advances and future prospects

Castro-Cosio,

Monreal-Escalante,

Romero-Geraldo

et al. 2023

Algal Research

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Oceanic Breakthroughs: Marine-Derived Innovations in Vaccination, Therapy, and Immune Health

Gamberi,

Leverette,

Davis

et al. 2024

Vaccines

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The vast, untapped potential of the world’s oceans is revealing groundbreaking advancements in human health and vaccination. Microalgae such as Nannochloropsis spp. and Dunaliella salina are emerging as resources for recombinant vaccine development with specific and heterologous genetic tools used to boost production of functional recombinant antigens in Dunaliella salina and Nannochloropsis spp. to induce immunoprotection. In humans, several antigens produced in microalgae have shown potential in combating diseases caused by the human papillomavirus, human immunodeficiency virus, hepatitis B virus, influenza virus, Zika virus, Zaire Ebola virus, Plasmodium falciparum, and Staphylococcus aureus. For animals, microalgae-derived vaccine prototypes have been developed to fight against the foot-and-mouth disease virus, classical swine fever virus, vibriosis, white spot syndrome virus, and Histophilus somni. Marine organisms offer unique advantages, including the ability to express complex antigens and sustainable production. Additionally, the oceans provide an array of bioactive compounds that serve as therapeutics, potent adjuvants, delivery systems, and immunomodulatory agents. These innovations from the sea not only enhance vaccine efficacy but also contribute to broader immunological and general health. This review explores the transformative role of marine-derived substances in modern medicine, emphasizing their importance in the ongoing battle against infectious diseases.

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Trypanosoma cruzi Tc24 Antigen Expressed and Orally Delivered by Schizochytrium sp. Microalga is Immunogenic in Mice

Cited by 3 publications

References 74 publications

Recent advances and fundamentals of microalgae cultivation technology

Recent advances and fundamentals of microalgae cultivation technology

Natural and recombinant bioactive compounds from Schizochytrium sp.: Recent advances and future prospects

Oceanic Breakthroughs: Marine-Derived Innovations in Vaccination, Therapy, and Immune Health

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