Trypanosoma (Herpetosoma) rangeli Tejera, 1920: nota prévia sobre a histopatologia em camundongos infectados experimentalmente

Abstract

SUMMARYMale mice (NMRI strain) of 3 and 5 g were inoculated i. p. with 8 x 10 6 and 9 x 10 4 metatrypomastigotes/g harvested from a 12-day-old LIT culture of Try panosoma rangeli of the "Dog-82" strain. At regular intervals after inoculation, the animals were sacrificed and portions of heart, liver, spleen, lung, thigh, kidney, stomach, intestine, brain, sternum, and vertebral column were embedded in paraffin, sectioned, and stained with haematoxylin-eosin and Giemsa colopho¬ nium. Pathology was encountered in the first five tissues cited above. The sub cutaneous, periosteal, interstitial, and peribronchial connective tissues, and later the muscle cells of the heart, were heavily parasitized by amastigotes and trypo¬ mastigotes. The possible reasons for the decrease in tissue parasitosis at the same time that the parasitemia is reaching its peak, and for the low level of in flammation in the parasitized tissues, are discussed. The observations of other workers, as well as the results described here, indicate that certain strains of T. rangeli under certain conditions may well cause pathological alterations in mammals.

Serological Diagnosis of Trypanosoma rangeli Infected Patients. A Comparison of Different Methods and its Implications for the Diagnosis of Chagas' Disease

“…While there appears to be no pathogenesis of infection in humans, experimental infections have been reported with parasites present in intracellular locations [42][43][44]. The parasite exists in the same areas as the pathogenic T. cruzi, and shares the same insect vectors.…”

Trypanosoma (Herpetosoma) rangeli Tejera, 1920: an updated review

“…These parasites disappeared 2 to 5 days after being infected without new free flagellates appearing in culture. Contrary to the forgoing, there are reports in the literature indicating the presence of reproductive T. rangeli forms in vertebrates (Grogl & Kuhn 1984, Scorza et al 1986, Osorio et al 1995. Urdaneta-Morales and Tejero (1986) have described finding T. rangeli amastigote forms in cross-sections of heart, liver and spleen taken from NMRI lactating mice inoculated with forms of Venezuelan Perro-82 strain culture.…”

Characterization of Trypanosoma rangeli Strains Isolated in Central and South America: an Overview

“…1). However, the life cycle of this parasite in the vertebrate host(s) remains unclear due to conflicting observations (D'Alessandro 1976, Urdaneta-Morales & Tejero 1985, Scorza et al 1986, D'Alessandro & Saravia 1998.…”