Tryptamine Analogs as Antidepressant and Anxiolytic Agents: Synthesis and In Vivo Evaluation

Asghar, Saira; Mushtaq, Nousheen; Khan, Aslam; Akhtar, Shamim; Munawar, Rabya; Ansari, Sumaira; Saify, Zafar Saeed

doi:10.1007/s11094-022-02727-7

Cited by 2 publications

(1 citation statement)

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“…In the present study the pharmacokinetic analysis of already reported derivatives of tryptamine [11] was executed by in silico tools. The structures of the tryptamine derivatives were drawn by using Chem Draw 2D Ultra and saved in .mol file format.…”

Section: Methodsmentioning

confidence: 99%

In Silico Pharmacokinetic Profiling of Tryptamine Derivatives by Swissadme and Admetsar

Asghar,

Iqtadar

2022

HJP

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Profiling of different pharmacokinetic parameters like the absorption, distribution, metabolism, and elimination known as ADME properties of drug molecules during initial phase of drug development might be beneficial in selection of molecules with less adverse ADME characteristics. ADME screening by in vivo testing is very time consuming, costly, and includes the animals. On the other hand, in silico ADME investigation is cheaper, better and offers correct results rapidly. In the current research study, the in-silico methods, namely SwissADME and admetSAR were used for brief and complete ADME profiling of previously selected (SR7, SR9, SR11, SR29, SR41 and SR43) tryptamine derivatives. The webservers utilized in this research are available for free. In-silico analyses have revealed that all the derivatives under study have high gastrointestinal absorption which make them a good oral drug candidate. However, results showed that SR41 & SR43 were able to pass blood- brain barrier as compared to other synthetic compounds of this series.

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Section: Methodsmentioning

confidence: 99%