Tryptophan and Nitrogen Metabolism and Pregnancy of the Rat as Affected by Dietary Supplementations with Leucine and with Amino Acid Mixtures ,

Lojkin, Mary E.

doi:10.1093/jn/100.1.51

Cited by 8 publications

(2 citation statements)

References 12 publications

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“…Lojkin [1970] re ported that supplementation of the rat diet with 5% leucine resulted in a negative nitro gen balance and impairment in the fetal con dition. However, the diet he used was niacinfree and contained low levels of tryptophan.…”

Section: Discussionmentioning

confidence: 99%

“…He also demonstrated that the effectiveness of leucine supplementation depends on the levels of the supplementation, since leucine was more effective at the 5% level than at the 2.5% level in depressing the tryptophan-nia cin pathway, nitrogen metabolism and in im pairing the fetal conditions. The effects could be reversed when the 2.5% leucine diet was supplemented with isoleucine and valine [Lojkin, 1970]. Several workers have re ported that leucine promotes protein synthe sis in rats and inhibits its degradation in mus cle and heart [Buse and Reid, 1975;Chua et al.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Excess Leucine on Tryptophan Oxygenase, 3-Hydroxyanthranilate Oxygenase and Leucine Aminotransferase in Livers of Young Rats

Chugh¹,

Shanker²,

Lal³

et al. 1982

Ann Nutr Metab

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Hepatic tryptophan oxygenase (EC 1.13.1.12) 3-hydroxyanthranilate oxygenase (EC 1.13.1.6) and leucine aminotransferase (EC 2.6.1.6) activities were determined in livers of rat pups of various ages whose mothers were fed on diets with or without excess leucine. Tryptophan oxygenase activity was detectable on the 20th day in both the groups and thereafter increased with age. Low activity of 3-hydroxyanthranilate oxygenase was observed at birth, the levels increased on the 10th day and thereafter remained unaltered on both diets. Leucine aminotransferase activity was highest at birth and thereafter decreased with age. Tryptophan oxygenase and leucine aminotransferase activities were significantly higher at all ages in livers of pups born to mothers given excess leucine in their diet.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Excess Leucine on Tryptophan Oxygenase, 3-Hydroxyanthranilate Oxygenase and Leucine Aminotransferase in Livers of Young Rats

Chugh¹,

Shanker²,

Lal³

et al. 1982

Ann Nutr Metab

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Metabolic and regulatory effects of branched chain amino acid supplementation

Lal¹,

Chugh²

1995

Nutrition Research

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Excretion of tryptophan-niacin metabolites by young men: effects of tryptophan, leucine, and vitamin B6 intakes

Patterson¹,

Brown²,

Linkswiler³

et al. 1980

The American Journal of Clinical Nutrition

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Three human metabolic studies, each 35 days in length, were performed to investigate the relationship between tryptophan intake and the proportion of dietary tryptophan converted to niacin and the effect of supplements of L-leucine and vitamin B6 on this conversion. Nine college men consumed a basal diet that provided 8 mg of niacin, 1 mg of vitamin B6, and either 245, 548, or 845 mg of tryptophan from proteins per day. During each 35-day study, for one 15-day period basal diet alone was consumed, for another 15-day period basal diet plus 10 g of L-leucine per day was consumed, and for the last 5-day period, 20 mg of vitamin B6 per day was added to the diets of both groups. N1-methylnicotinamide, N1-methyl-2-pyridone-5-carboxamide, and quinolinic acid were measured in 24-hr urine samples. There were no significant or consistent effects of L-leucine or vitamin B6 supplements on the excretin of any of the metabolites measured. The proportion of tryptophan converted to niacin tended to increase as tryptophan consumption increased; however, this change was small and was probably not significant over the range of tryptophan intakes studied. The average conversion ration of tryptophan to niacin was approximately 72:1 in these subjects.

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Tryptophan and Nitrogen Metabolism and Pregnancy of the Rat as Affected by Dietary Supplementations with Leucine and with Amino Acid Mixtures ,

Cited by 8 publications

References 12 publications

Effect of Excess Leucine on Tryptophan Oxygenase, 3-Hydroxyanthranilate Oxygenase and Leucine Aminotransferase in Livers of Young Rats

Effect of Excess Leucine on Tryptophan Oxygenase, 3-Hydroxyanthranilate Oxygenase and Leucine Aminotransferase in Livers of Young Rats

Metabolic and regulatory effects of branched chain amino acid supplementation

Excretion of tryptophan-niacin metabolites by young men: effects of tryptophan, leucine, and vitamin B6 intakes

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