Tryptophan-induced central fatigue in exercising rats is related to serotonin content in preoptic area

Effects of <i>Phellinus linteus </i>Administration on Serotonin Synthesis in the Brain and Expression of Monocarboxylate Transporters in the Muscle during Exhaustive Exercise in Rats

“…Fatigue during prolonged exercise may be influenced by the activity of the brain serotonergic system, and this is referred as the "central fatigue hypothesis" (64). It has been suggested that elevated central tryptophan availability increases 5-HT activity during prolonged exercise, which causes fatigue by increasing lethargy and loss of central motivation (64,65).…”

Morfologia e contratilidade em cardiomiócitos de ratos com baixo desempenho para o exercício físico

“…The test was stopped when the animal entered in fatigue. The moment of fatigue was defined when the rat could not keep running at the treadmill speed 12,13 .…”

The Involvement of Brain Monoamines in the Onset of Hyperthermic Central Fatigue

“…We have shown that before any harm can occur, afferent information from different physiological systems must be centrally integrated, and exercise must be voluntarily interrupted (Balthazar et al, 2009A. G. Rodrigues et al, 2004Soares et al, 2004Soares et al, , 2007.…”

“…In addition, both spontaneous and electrically evoked serotonin release from hypothalamic slices have been shown to be dependent on precursor availability, which causes parallel changes in brain serotonin levels and serotonin release (Schaechter & Wurtman, 1990). Central serotonin activity can affect many physiological responses, such as pain tolerance (Prieto-Gomez et al, 1989), motor activity (Gerin & Privat, 1998), thermoregulation (Imeri et al, 2000;Lin et al, 1998;Myers, 1981, Soares et al, 2007 and hypothalamo-pituitaryadrenal axis activity (Chaouloff, 2000;Korte et al, 1991). Thus, alterations in one or more of the physiological responses mediated by the serotonergic system may decrease work capacity during exercise.…”

“…Thus, alterations in one or more of the physiological responses mediated by the serotonergic system may decrease work capacity during exercise. It has been shown that an increased availability of tryptophan, in the central nervous system reduces the mechanical efficiency and running time to fatigue, which are both related to serotonin content in the preoptic area (Soares et al, 2003(Soares et al, , 2007. Moreover, serotonin content in the preoptic area is also associated with increased heat production and storage during exercise (Soares et al, 2007).…”