Tryptophan metabolism promotes immune evasion in human pancreatic β cells

Rachdi, Latif; Zhou, Zhicheng; Berthault, Claire; Lourenço, Chloé; Fouque, Alexis; Domet, Thomas; Armanet, Mathieu; You, Sylvaine; Peakman, Mark; Mallone, Roberto; Scharfmann, Raphaël

doi:10.1016/j.ebiom.2023.104740

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Cited by 5 publications

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Probiotics and Their Immunomodulatory Properties

Singh,

Mal,

Kalra

et al. 2024

Probiotics as Live Biotherapeutics for Veterinary and Human Health, Volume 2

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Probiotics and Their Immunomodulatory Properties

Singh,

Mal,

Kalra

et al. 2024

Probiotics as Live Biotherapeutics for Veterinary and Human Health, Volume 2

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Host-intestinal microbiota interactions in Edwardsiella piscicida-induced lethal enteritis in big-belly seahorses: Novel insights into the role of Carbohydrate-Active enzymes and host transcriptional responses

Jia,

Zhang,

Yang

et al. 2025

Fish & Shellfish Immunology

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Bacteria Engineered to Produce Serotonin Modulate Host Intestinal Physiology

Mavros,

Bongers,

Neergaard

et al. 2024

ACS Synth. Biol.

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Bacteria in the gastrointestinal tract play a crucial role in intestinal motility, homeostasis, and dysfunction. Unraveling the mechanisms by which microbes impact the host poses many challenges due to the extensive array of metabolites produced or metabolized by bacteria in the gut. Here, we describe the engineering of a gut commensal bacterium, Escherichia coli Nissle 1917, to biosynthesize the human metabolite serotonin for examining the effects of microbially produced biogenic amines on host physiology. Upon oral administration to mice, our engineered bacteria reach the large intestine, where they produce serotonin. Mice treated with serotonin-producing bacteria exhibited biological changes in the gut at transcriptional and physiological levels. This work establishes a novel framework employing engineered bacteria to modulate luminal serotonin levels and suggests potential clinical applications of modified microbial therapeutics to address gut disorders in humans.

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Tryptophan metabolism promotes immune evasion in human pancreatic β cells

Cited by 5 publications

References 93 publications

Probiotics and Their Immunomodulatory Properties

Probiotics and Their Immunomodulatory Properties

Host-intestinal microbiota interactions in Edwardsiella piscicida-induced lethal enteritis in big-belly seahorses: Novel insights into the role of Carbohydrate-Active enzymes and host transcriptional responses

Bacteria Engineered to Produce Serotonin Modulate Host Intestinal Physiology

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