Tryptophan pathway alterations in the postpartum period and in acute postpartum psychosis and depression

Veen, Cato; Myint, Aye-Mu; Burgerhout, Karin M.; Schwarz, Markus J.; Schütze, Gregor; Kushner, Steven A.; Hoogendijk, Witte J.G.; Drexhage, Hemmo A.; Bergink, Veerle

doi:10.1016/j.jad.2015.09.064

Cited by 55 publications

(30 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Clearly, the results indicate the relevance of changes in the kynurenine pathway in PDS pathophysiology, as indicated by comparisons in the levels and ratios of kynurenine pathway products in women with, versus without, PDS. This is supported by previous data (Veen et al, ; Wang et al, ).…”

Section: Discussionsupporting

confidence: 93%

The role of kynurenine pathway and kynurenic aminotransferase alleles in postpartum depression following cesarean section in Chinese women

et al. 2020

View full text Add to dashboard Cite

Objectives: A growing body of data indicates that the kynurenine pathway may play a role in the pathogenesis of postpartum depressive symptoms (PDS). Kynurenic aminotransferase (KAT) is an important kynurenine pathway enzyme, catalyzing kynurenine (KYN) into kynurenic acid (KYNA). This study investigated as to whether genetic variations in KAT are associated with PDS. Methods: A cohort of 360 Chinese women scheduled to undergo cesarean delivery was enrolled into this study. PDS was determined by an Edinburgh Postnatal Depression Scale (EPDS) score ≥ 13. A total of eight KAT single nucleotide polymorphisms (SNPs) were genotyped and their association with PDS investigated. Serum concentrations of KYN, KYNA, and quinolinic acid (QUIN) in women with or without PDS were also measured. This allowed the determination of the KYNA/KYN ratio, which is reflective of KAT activity.Results: Postpartum depressive symptoms incidence was 7.2%. Advanced maternal age, lower education, antenatal depression, and postpartum blues were risk factors for PDS (p < .05). Women with PDS, versus non-PDS, had heightened KYN levels one day prior to surgery (ante-d1) (p < .05), as well as having significantly lower KYNA and higher QUIN levels at postnatal day three (post-d3) (p < .05). Women with, versus without, PDS also had a significantly higher QUIN/KYNA ratio at post-d3 (p < .05). KAT activity was significantly lower in women with, versus without, PDS at ante-d3 (p < .05). No significant association was evident between the KAT SNPs and PDS.Conclusion: Our data support a role for alterations in the kynurenine pathway in the pathogenesis of PDS, although no significant association was found for the eight tested KAT SNPs with PDS.

show abstract

Section: Discussionsupporting

confidence: 93%

The role of kynurenine pathway and kynurenic aminotransferase alleles in postpartum depression following cesarean section in Chinese women

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Studies to date have focussed on levels of tryptophan and its metabolites ( i.e ., precursors of serotonin)[16], and the immune[13] and thyroid[14] systems, the latter two systems being in considerable flux during pregnancy and in the perinatal period. The main findings of these studies may be summarised, respectively, as: (1) deficient tryptophan breakdown, and lower kynurenine production, is evident in women with postpartum mood disorders; (2) abnormally low T cell numbers, and over-activation of the monocyte/macrophage arm of the immune system is evident in the postpartum period in women diagnosed with PP; and (3) patients with PP have a higher prevalence of autoimmune thyroid disease than controls.…”

Section: Current Approaches To Understanding Postpartum Psychosis Andmentioning

confidence: 99%

Understanding the pathophysiology of postpartum psychosis: Challenges and new approaches

Davies

2017

WJP

View full text Add to dashboard Cite

Postpartum psychosis is a severe psychiatric condition which affects 1-2 of every 1000 mothers shortly after childbirth. Whilst there is convincing evidence that the condition is precipitated by a complex combination of biological and environmental factors, as yet the pathophysiological mechanisms remain extremely poorly defined. Here, I critically review approaches that have been, or are being, employed to identify and characterise such mechanisms; I also review a recent animal model approach, and describe a novel biological risk model that it suggests. Clarification of biological risk mechanisms underlying disorder risk should permit the identification of relevant predictive biomarkers which will ensure that “at risk” subjects receive prompt clinical intervention if required.

show abstract

“…Embora os estudos sobre o metabólitos do TRP sejam, em geral, centralizados na via da 5-HT, devido à sua importância como neurotransmissor (14), as vias de metabolização do TRP já foram associadas a doenças neurodegenerativas como a doença de Alzheimer (15) e a de Huntington (16,17). Alterações nos níveis do TRP e em suas vias, já foram descritas em doenças infecciosas como a imunodeficiência viral humana (HIV) (18), em alergias (19), na depressão (20), em doenças auto-imunes como o lúpus (21), e em inflamações diversas (22,23). Nos últimos anos, a via das QUINs e do metabolismo do TRP vêm ganhado destaque como um importante regulador da produção de agentes neuroprotetores (como o ácido quinurênico, o ácido picolínico e o cofator NAD + ) e neurotóxicos (como o AQ e a 3-HK).…”

Section: (Figura 1)unclassified

“…A metabolização do TRP pela via da QUIN pode ainda contribuir para uma menor integridade estrutural e funcional da substância branca observada em pacientes portadores de SCZ, sugerindo uma possível correlação entre esta alteração estrutural e os menores níveis de TRP e da maior razão TRP/QUIN em plasma de pacientes SCZ (32). A via da QUIN está alterada em grande número de doenças neuropsiquiátricas, e a produção de mediadores inflamatórios, como as citocinas e quimiocinas, é capaz de aumentar a atividade da enzima indoleamina-2,3-dioxigenase (IDO) (20,24,29), que é fundamental para o metabolismo do TRP e a sua conversão em QUIN nos diferentes tecidos (12). Além de ativar a via da QUIN, as citocinas depletam o TRP, que é o precursor primário da 5-HT, e geram metabólitos neuroativos que podem influenciar significativamente na regulação da via da dopamina (DA) e do glutamato (GLU).…”

Section: Via Das Quinureninas (Quin)unclassified

Metabolismo Do Triptofano Em Transtornos Mentais: Um Enfoque Na Esquizofrenia

Carvalho¹,

Yonamine²,

Mas³

et al. 2017

VITTALLE, ISSN 1413-3563, Rio Grande, Brasil

View full text Add to dashboard Cite

O triptofano (TRP) é um aminoácido essencial, encontrado no plasma principalmente ligado à albumina, e com apenas uma pequena fração encontrada na forma livre. Ao atravessar a barreia hematoencefálica, seus metabólitos exercem diferentes ações no sistema nervoso central. Importantes metabólitos neuroativos resultantes do metabolismo do TRP (como a serotonina, melatonina, 3-hidroxiquinurenina, ácido quinolínico e quinurênico, dentre outros) têm sido associados a doenças neurodegenerativas como o Mal de Alzheimer, a doença de Huntington, o transtorno bipolar (TB) e a esquizofrenia (SCZ). Além disto, há também relatos sobre a sua relação com a depressão, as doenças inflamatórias, diversas alergias e com doenças infecciosas. O objetivo deste trabalho foi reunir informações recentes e atualizadas sobre o que se sabe sobre papel do TRP e as seus metabólitos, enfatizando a relação desse aminoácido e seus metabólitos na fisiopatologia da SCZ, com enfoque na via das quinureninas e sobretudo suas eventuais associações com as doenças mentais.

show abstract

Tryptophan pathway alterations in the postpartum period and in acute postpartum psychosis and depression

Cited by 55 publications

References 46 publications

The role of kynurenine pathway and kynurenic aminotransferase alleles in postpartum depression following cesarean section in Chinese women

The role of kynurenine pathway and kynurenic aminotransferase alleles in postpartum depression following cesarean section in Chinese women

Understanding the pathophysiology of postpartum psychosis: Challenges and new approaches

Metabolismo Do Triptofano Em Transtornos Mentais: Um Enfoque Na Esquizofrenia

Contact Info

Product

Resources

About