TSH-Secreting Pituitary Macroadenoma in a Girl with Lingual Thyroid

Wacharasindhu, Suttipong; Shuangshoti, Shanop; Sunthornyothin, Sarat

doi:10.1155/2013/570847

Cited by 3 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, it is suggested that patients with pituitary enlargement on MRI associated with hypothyroidism should undergo extensive endocrine work up and given trial of hormonal replacement first. This can avoid unnecessary surgery (9).…”

Section: Discussionmentioning

confidence: 97%

A Case of Hoffman Syndrome Masquerading as Pituitary Tumour

Bhartiya

Ghosh²,

Singh³

et al. 2017

IJMSCI

View full text Add to dashboard Cite

Hoffman syndrome, a rare presentation of hypothyroidism, is characterized by pseudo-hypertrophy and stiffness of muscles, myxoedematous features. Long standing hypothyroidism can cause pituitary hyperplasia which is difficult to distinguish with pituitary adenoma even with contrast MRI. We describe a case of a 48 years old male presenting as 'Hoffman syndrome' with reactive pituitary hyperplasia that mimicked a pituitary macroadenoma. After 20 days of thyroid hormone therapy, the patient had improvement of the muscular cramps. After 03 months of active therapy a repeat MRI was done which showed regression of size of the mass. In a case of primary hypothyroidism with a solid mass lesion of the pituitary gland, pituitary hyperplasia secondary to hypothyroidism rather than pituitary adenoma should be excluded to avoid unnecessary surgical intervention which has its own complications.

show abstract

Section: Discussionmentioning

confidence: 97%

A Case of Hoffman Syndrome Masquerading as Pituitary Tumour

Bhartiya

Ghosh²,

Singh³

et al. 2017

IJMSCI

View full text Add to dashboard Cite

show abstract

“…In cases of primary hypothyroidism associated with pituitary enlargement, MRI after therapy with thyroxine may provide a definitive diagnosis and eliminate unnecessary surgery. Surgery is rarely indicated in cases such as thyrotrophic hyperplasia with severe symptoms from mass effect not responding to thyroxine replacement therapy (12).…”

Section: Discussionmentioning

confidence: 99%

Pituitary hyperplasia mimicking macroadenoma secondary to primary hypothyroidism

Toromanović

Tahirović

2016

Pedaiatr Today

View full text Add to dashboard Cite

Objective -We aim to emphasize the importance of extensive endocrine workup in cases of pituitary masses. Case report -We report on a case of pituitary thyrotrophic hyperplasia in a 12-year-old girl who was thought to have a pituitary macroadenoma with suprasellar extension. The main complaint was headache, while other symptoms of hypothyroidism were present, but weren't recognised. Hormonal testing revealed low total thyroxine (<12.8 nmol/l) and high TSH (310.5 mIU/l) levels, and hyperprolactinemia (prolactin level at 1680 mIU/l). Based on the clinical history, laboratory data, and MRI, a diagnosis of pituitary hyperplasia secondary to primary hypothyroidism, consequent to chronic autoimmune thyroiditis, was made. Therapy with levothyroxine was initiated at 50 µg/day and gradually increased to 75 µg daily. After three months of thyroxine replacement, she was clinically and biochemically euthyroid. A follow-up MRI, 4 months after thyroxine replacement was initiated, showed complete resolution of the mass, and normal pituitary gland. Conclusion -Primary hypothyroidism should be considered in the differential diagnosis of pituitary masses. Multidisciplinary assessment in these cases will help to avoid delays in diagnosis and prevent unnecessary surgery.

show abstract

“…Napjainkban a labordiagnosztika fejlődésével a kórkép általában korábbi stádiumban kerül felismerésre [2]. A betegségben a TSH-szekréció autonóm és refrakter a perifériás pajzsmirigyhormonok negatív feedback hatásával szemben [5]. A hyperthyreosis tünetei általában enyhébbek, mint a Graves-Basedow-kóros betegek esetében; struma gyakran társul a kórképhez, endocrin orbitopathia viszont soha nem fordul elő [6].…”

Section: Esetismertetésunclassified

Tirotropintermelő hypophysisadenoma

Sohár¹,

Györkös²,

Dóczi

et al. 2020

View full text Add to dashboard Cite

Absztrakt: A tirotropintermelő hypophysistumor a hyperthyreosis ritka oka, a hypophysisadenomák 1 százalékában fordul elő. Az utóbbi években a felismert esetek száma nőtt az ultraszenzitív immunometriás esszék elterjedésének köszönhetően. A klinikai gyakorlatban a normál- vagy emelkedett tirotropinérték mellett észlelt emelkedett perifériás pajzsmirigyhormonszintek esetében kell felvetni a tirotropintermelő tumor lehetőségét. A szerzők egy középkorú nőbeteg esetét ismertetik, akinél a centrális hyperthyreosis hátterében tirotropintermelő hypophysis-macroadenoma igazolódott. Átmeneti thyreostaticus kezelést követően a tumor radikális idegsebészeti eltávolítása megtörtént. A műtétet követően a beteg hyperthyreosisa megszűnt, a residualis hypophysisfunkció megtartott maradt. Gondozása során recidívára utaló eltérést nem észleltünk. Esetismertetésünkben a kórkép felismerése kapcsán felmerülő differenciáldiagnosztikai nehézségeket is taglaljuk. Orv Hetil. 2020; 161(12): 474–478.

show abstract

TSH-Secreting Pituitary Macroadenoma in a Girl with Lingual Thyroid

Cited by 3 publications

References 13 publications

A Case of Hoffman Syndrome Masquerading as Pituitary Tumour

A Case of Hoffman Syndrome Masquerading as Pituitary Tumour

Pituitary hyperplasia mimicking macroadenoma secondary to primary hypothyroidism

Tirotropintermelő hypophysisadenoma

Contact Info

Product

Resources

About