Tsukamurella paurometabolum: A Novel Pathogen Causing Catheter-Related Bacteremia in Patients with Cancer

Shapiro, Charles L.; Haft, Rachel F.; Gantz, Nelson M.; Doern, Gary V.; Christenson, John C.; O’Brien, Richard; Overall, James C.; Brown, Barbara A.; Wallace, Richard J.

doi:10.1093/clinids/14.1.200

Cited by 39 publications

(21 citation statements)

References 9 publications

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“…Testing for sugar utilization with the API 50 CH system showed excellent correlation with published data based on tests with conventional biochemicals. However, with degradation agars, we found inconsistencies among different studies and with our results (2,24,(34)(35)(36). Moreover, in our study we found discrepancies between different commercial systems.…”

Section: G Aurantiaca Was Renamed Rhodococcus Aurantiacus By Tcontrasting

confidence: 78%

Tsukamurella strandjordae sp. nov., a Proposed New Species Causing Sepsis

Kattar

Cookson²,

Carlson³

et al. 2001

J Clin Microbiol

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We have isolated a gram-positive, weakly acid-alcohol-fast, irregular rod-shaped bacterium from cultures of blood from a 5-year-old girl with acute myelogenous leukemia. This isolate was compared with 14 other strains including reference strains of Tsukamurella species by a polyphasic approach based on physiological and biochemical properties, whole-cell short-chain fatty acid and mycolic acid analyses, DNA-DNA hybridization, and sequencing of the 16S rRNA gene. This isolate represents a new taxon within the genus Tsukamurella for which we propose the name Tsukamurella strandjordae sp. nov. Our study also revealed that Tsukamurella paurometabola ATCC 25938 represents a misnamed Tsukamurella inchonensis isolate and confirms that Tsukamurella wratislaviensis belongs to the genus Rhodococcus.Tsukamurellae are members of the mycolic acid-containing aerobic actinomycetes. The genus was created in 1988 to accommodate a group of chemically unique organisms characterized by a series of very long chain (68 to 76 carbons) highly unsaturated (two to six double bonds) mycolic acids, in addition to possessing meso-diaminopimelic acid and arabinogalactan, common to the genus Corynebacterium (6). The type species, Tsukamurella paurometabola, described by Steinhaus as Corynebacterium paurometabolum in 1941, was originally isolated from the mycetomes and ovaries of bed bugs (27). The first human isolate of Tsukamurella was reported in 1971 as Gordona aurantiaca (33). Four additional species were proposed in the 1990s. Tsukamurella wratislaviensis was isolated from soil (10). Strains of Tsukamurella inchonensis, Tsukamurella pulmonis, and Tsukamurella tyrosinosolvens have been isolated only from human specimens, and all were associated with clinical disease (34-36). We have encountered an unusual isolate in multiple cultures of blood from a 5-year-old girl with acute myelogenous leukemia who presented with sepsis. On the basis of physiological and biochemical characteristics, analysis of cell components, DNA-DNA hybridizations, and the 16S rRNA gene sequence, we propose that this strain represents a new taxon within the genus Tsukamurella to which we assign the name Tsukamurella strandjordae sp. nov. Our study compared this isolate to reference and clinical strains of the other Tsukamurella species and found that T. paurometabola ATCC 25938 is a misnamed T. inchonensis isolate. MATERIAL AND METHODSStrains. The study included type strains of all proposed Tsukamurella species. T. paurometabola ATCC 8368 and T. wratislaviensis ATCC 51786 were purchased from the American Type Culture Collection (ATCC). A. F. Yassin generously provided the type strains T. pulmonis ATCC 700081 and T. inchonesis ATCC 700082. Type strain T. tyrosinosolvens DSMZ 44234 was purchased from the Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSMZ; Braunschweig, Germany). Other purchased reference strains included strains T. paurometabola ATCC 25938 and T. tyrosinosolvens DSMZ 44316. The strain of T. strandjordae, the subject of this study, was is...

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Section: G Aurantiaca Was Renamed Rhodococcus Aurantiacus By Tcontrasting

confidence: 78%

Tsukamurella strandjordae sp. nov., a Proposed New Species Causing Sepsis

Kattar

Cookson²,

Carlson³

et al. 2001

J Clin Microbiol

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“…Cases of human infection with T. paurometabola are infrequent, nevertheless diagnosis rates are increasing, typically in patients with underlying predisposing factors, including immunosuppression (8,9), chronic pathology (6), and indwelling foreign bodies (10). However, there are a number of reported cases in which infected patients had no underlying factors, with Granel et al (11) describing an inflammatory cutaneous infection in an otherwise healthy individual.…”

mentioning

confidence: 99%

Tsukamurella paurometabola Lipoglycan, a New Lipoarabinomannan Variant with Pro-inflammatory Activity

Gibson

Gilleron²,

Constant³

et al. 2004

Journal of Biological Chemistry

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“…The most common Tsukamurella infections in human are indwelling device-related infections, including catheter-related bacteremia, especially that of the central venous catheter (7,10,14,16,17), peritonitis associated with continuous ambulatory peritoneal dialysis (15), and knee prosthesis infection (8). Most cases of human infection reported in the literature were caused by T. paurometabola.…”

mentioning

confidence: 99%

Tsukamurella Conjunctivitis: a Novel Clinical Syndrome

et al. 2003

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In this report, we describe the first three cases of Tsukamurella conjunctivitis in the literature. All three patients presented with congestion of one eye with small amounts of serous discharge for 1 to 2 days. All three recovered after 10 days of treatment with polymyxin B-neomycin or chloramphenicol eyedrops. Sequencing of the 16S rRNA genes of the three isolates recovered from the serous discharge of the three patients showed that they were all Tsukamurella species. The phenotypic characteristics of the isolate obtained from one patient best fit the phenotypic profile of Tsukamurella pulmonis, whereas those of the other two best fit that of Tsukamurella tyrosinosolvens.

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Tsukamurella paurometabolum: A Novel Pathogen Causing Catheter-Related Bacteremia in Patients with Cancer

Cited by 39 publications

References 9 publications

Tsukamurella strandjordae sp. nov., a Proposed New Species Causing Sepsis

Tsukamurella strandjordae sp. nov., a Proposed New Species Causing Sepsis

Tsukamurella paurometabola Lipoglycan, a New Lipoarabinomannan Variant with Pro-inflammatory Activity

Tsukamurella Conjunctivitis: a Novel Clinical Syndrome

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