2009
DOI: 10.1111/j.1742-7843.2008.00341.x
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(TTA)n Polymorphism in 3‐Hydroxy‐3‐Methylglutaryl‐Coenzyme A and Response to Atorvastatin in Coronary Artery Disease Patients

Abstract: 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors have been used clinically for lowering total and low-density lipoprotein cholesterol. Interindividual pharmacological differences observed with this treatment have been attributed to genetic differences. The aim of this study was to assess the association in the low-density lipoprotein cholesterol reduction by atorvastatin and (TTA)n polymorphism in the 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene in patients with coronary artery disease. Chang… Show more

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Cited by 7 publications
(2 citation statements)
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“…However, the aggressive atorvastatin dose of 80 mg/d increased the urinary 8-iso-PGF 2␣ excretion, yet this increase failed very nearly statistical significance (P = 0.07). Thus far, several groups have investigated the effect of atorvastatin and other statins on oxidative stress, including 8-iso-PGF 2␣ , in different diseases and conditions including hypercholesterolemia with diverging results [45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64].…”
Section: Oxidative Stressmentioning
confidence: 99%
“…However, the aggressive atorvastatin dose of 80 mg/d increased the urinary 8-iso-PGF 2␣ excretion, yet this increase failed very nearly statistical significance (P = 0.07). Thus far, several groups have investigated the effect of atorvastatin and other statins on oxidative stress, including 8-iso-PGF 2␣ , in different diseases and conditions including hypercholesterolemia with diverging results [45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64].…”
Section: Oxidative Stressmentioning
confidence: 99%
“…Most studies were conducted in Brazil [ 3 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 ]. Six studies were conducted in Argentina [ 59 60 61 62 63 64 ], four in Chile [ 65 66 67 68 ], four in Colombia [ 69 70 71 72 ], three in Uruguay [ 73 74 75 ] and two were multi-country studies conducted in Argentina, Brazil, Chile and Colombia [ 12 ] and Brazil and Suriname [ 76 ]. The most common language of the articles was English (58 articles), followed by Spanish (11 articles) and Portuguese (4 articles).…”
Section: Resultsmentioning
confidence: 99%