TTF[Ni(dmit)2]2: From single-crystals to thin layers, nanowires, and nanoparticles

Valade, Lydie; de, Dominique; Faulmann, Christophe; Jacob, Kane

doi:10.1016/j.ccr.2015.05.014

Cited by 19 publications

(11 citation statements)

References 92 publications

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“…Small molecules also possess substantial untapped potential to perform many frontier functions, 1 including modulating protein-protein interactions, 2 allosterically modifying protein function, 3 acting as prostheses on the molecular scale, 4,5 serving as next-generation biological probes, 6–9 enabling miniaturized diagnostics, 10 transducing energy, 11–16 emitting light, 17 initiating self-healing, 18 acting as molecular magnets, 19 enabling next generation computing, 20 and superconducting. 21–22 However, largely due to limitations in synthesis, much of this functional potential remains largely untapped. Eliminating this synthesis bottleneck thus represents both a major challenge and an extraordinary opportunity for the field of Chemistry.…”

Section: Introductionmentioning

confidence: 99%

Towards the generalized iterative synthesis of small molecules

2018

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Small molecules have extensive untapped potential to benefit society, but access to this potential is too often restricted by limitations inherent to the customized approach currently used to synthesize this class of chemical matter. In contrast, the “building block approach”, i.e., generalized iterative assembly of interchangeable parts, has now proven to be a highly efficient and flexible way to construct things ranging all the way from skyscrapers to macromolecules to artificial intelligence algorithms. The structural redundancy found in many small molecules suggests that they possess a similar capacity for generalized building block-based construction. It is also encouraging that many customized iterative synthesis methods have been developed that improve access to specific classes of small molecules. There has also been substantial recent progress toward the iterative assembly of many different types of small molecules, including complex natural products, pharmaceuticals, biological probes, and materials, using common building blocks and coupling chemistry. Collectively, these advances suggest that a generalized building block approach for small molecule synthesis may be within reach.

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Section: Introductionmentioning

confidence: 99%

Towards the generalized iterative synthesis of small molecules

2018

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“…Kurzaufsätze gewinnen und zusätzlich optimale Bedingungen fürj ede Reaktion testen (Schema 13). [115] Auch Cronin et al entwickelten ein Reaktorsystem mit Selbstoptimierung mithilfe von Echtzeit-online-NMR-Spektroskopie zur Datenanalyse.Durch die Auswertung von 13 C-, 19 F-und 2D-NMR-Spektren der Reaktionsmischung unter kontinuierlichen Bedingungen ermçglichte diese Technik diverse kinetische und mechanistische Studien. Die Selbstoptimierung erfolgte über Online-1 H-NMR-Spektroskopie.Die untersuchten Modellreaktionen umfassten eine Iminbildung und elektrophile Fluorierung (Schema 14).…”

Section: Angewandte Chemieunclassified

“…[6] Diese Annahme scheint berechtigt, weil das Anwendungspotenzial organischer Materialien in modernen Te chnologien bis jetzt kaum ausgeschçpft wurde.D ie bislang untersuchten Aspekte umfassen Protein-Protein-Wechselwirkungen, [7] die allosterische Modifizierung von Proteinfunktionen, [8] den Einsatz als molekulare Prothesen [9] oder biologische Sonden der nächsten Generation, [10] die Verwirklichung miniaturisierter Diagnostik, [11] das Ernten von Sonnenlicht, [12] Energie-Übermittlung, [13] das Ausstrahlen von Licht, [14] initiierte Selbstheilung, [15] molekularen Magnetismus, [16] den Einsatz als Redox-Flow-Batterien, [17] Entwicklung von EDV der nächsten Generation [18] und Supraleitung. [19] Durch die Erschließung dieses ungenutzten Potenzials auf der molekularen Ebene kçnnten wichtige Probleme der heutigen Gesellschaft adressiert und mçglicherweise gelçst werden. Allerdings ist die händische Synthese organischer Substanzen von Natur aus zeitaufwändig und normalerweise ein Prozess,d er nur von Spezialisten ausgeführt werden kann, was zu einer Engstelle in der Produktion unterschiedlicher organischer Moleküle führt, deren Funktionen studiert werden kçnnten.…”

Section: Introductionunclassified

Die molekulare industrielle Revolution: zur automatisierten Synthese organischer Verbindungen

Trobe

Burke

2018

Angewandte Chemie

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Derzeitkündigt sichein Wandel von der manuellen Synthese spezifischer Moleküle,die über individuell angepasste Routen verläuft, hin zu automatisch zusammenfügten Verbindungen unterschiedlichster Klassen mit nur einem Knopfdruckan. Die Entwicklung einer Maschine fürdie Herstellung unterschiedlichsterorganischer Moleküle je nachBedarf ist eine komplexe Aufgabe,e ss ind aber bereits bedeutende Fortschritte auf Basis von zwei komplementären Ansätzen zu verzeichnen:1 )Automatisierung individueller Routen fürdie Synthese diverser Verbindungen, wobei viele unterschiedliche Reaktionstypen und spezifische Reagentien genutzt werden kçnnen, und 2) Automatisierung einer generellen Plattform, die die Herstellung unterschiedlicher Verbindungen ausgehend von diversen Bausteinen, die mit derselben Kupplungsreaktion verknüpft werden, ermçglicht. Fortschritte in diesen Bereichen bieten die Mçglichkeit, Synthese-Engpässe zu vermeiden und den Fokus molekularer Innovation auf die Entwicklung neuer Methoden zu lenken und so eine "molekulare industrielle Revolution" zu beschleunigen.

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“…[12] transducing energy, [13] emitting light, [14] initiating self-healing, [15] acting as molecular magnets, [16] acting as redox flow batteries, [17] enabling next generation computing, [18] and superconducting. [19] Harnessing this untapped functional potential on the molecular scale could help address some of the most important problems facing societies today. However, the hand-crafted and thus inherently slow and specialist-dependent process via which most small molecules are still synthesized represents a significant bottleneck in such efforts.…”

Section: Introductionmentioning

confidence: 99%

“…[6] This is because this class of chemical matter can also perform many frontier functions that have been minimally utilized to date.T hese include modulating protein-protein interactions, [7] allosterically modifying protein function, [8] acting as prostheses on the molecular scale, [9] serving as next-generation biological probes, [10] enabling miniaturized diagnostics, [11] harvesting sunlight, [12] transducing energy, [13] emitting light, [14] initiating self-healing, [15] acting as molecular magnets, [16] acting as redox flow batteries, [17] enabling next generation computing, [18] and superconducting. [19] Harnessing this untapped functional potential on the molecular scale could help address some of the most important problems facing societies today.H owever,t he hand-crafted and thus inherently slow and specialist-dependent process through which most small molecules are still synthesized represents as ignificant bottleneck in such efforts.T he automation of small-molecule synthesis has the potential to eliminate this bottleneck and thereby enable widespread innovation on the molecular scale.…”

Section: Introductionmentioning

confidence: 99%

The Molecular Industrial Revolution: Automated Synthesis of Small Molecules

2018

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The eighteenth and nineteenth centuries marked a sweeping transition from manual to automated manufacturing on the macroscopic scale. This enabled an unmatched period of human innovation that helped drive the Industrial Revolution. The impact on society was transformative, ultimately yielding substantial improvements in living conditions and lifespan in many parts of the world. During the same time period, the first manual syntheses of organic molecules was achieved. Now, two centuries later, we are poised for an analogous transition from highly customized crafting of specific molecular targets by hand to the increasingly general and automated assembly of many different types of molecules with the push of a button. Automation of customized small molecule synthesis pathways is already enabling safer, more reproducible, and readily scalable production of specific targets, and general machines now exist for the synthesis of a wide range of different peptides, oligonucleotides, and oligosaccharides. Creating general machines that are similarly capable of making many different types of small molecules on-demand, akin to that which has been achieved on the macroscopic scale with 3D printers, has proven to be substantially more challenging. Yet important progress is being made toward this potentially transformative objective with two complementary approaches: (1) automation of customized synthesis routes to different targets via machines that enable use of many different reactions and starting materials, and (2) automation of generalized platforms that make many different targets using common coupling chemistry and building blocks. Continued progress in these exciting directions has the potential to shift the bottleneck in molecular innovation from synthesis to imagination, and thereby help drive a new industrial revolution on the molecular scale.

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TTF[Ni(dmit)2]2: From single-crystals to thin layers, nanowires, and nanoparticles

Cited by 19 publications

References 92 publications

Towards the generalized iterative synthesis of small molecules

Towards the generalized iterative synthesis of small molecules

Die molekulare industrielle Revolution: zur automatisierten Synthese organischer Verbindungen

The Molecular Industrial Revolution: Automated Synthesis of Small Molecules

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