TTYH3, a potential prognosis biomarker associated with immune infiltration and immunotherapy response in lung cancer

Wei, Zimeng; Zeng, Xingruo; Lei, Yufei; He, Hengjing; Jamal, Muhammad; Zhang, Chengjie; Tan, Haidong; Xie, Songping; Zhang, Qiuping

doi:10.1016/j.intimp.2022.108999

Cited by 6 publications

(2 citation statements)

References 57 publications

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“…Among the most up-regulated proteins, those like Lama4 and Nid2 implicated in chondrogenesis, and Lgals3bp associated with osteogenesis, may contribute to cartilage regeneration [ 50 , 51 ]. Furthermore, Ttyh3 positively correlates with cell proliferation, migration, and immune cell function [ 52 , 53 ]. In mice with collagen-induced arthritis, PTX3 administration significantly reduced cartilage and bone destruction [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the ability of exosomes and ectosomes derived from adipose-derived stromal cells to promote cartilage regeneration in a rat osteochondral defect model

Xu,

Yu,

et al. 2024

Stem Cell Res Ther

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Background Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) offer promising prospects for stimulating cartilage regeneration. The different formation mechanisms suggest that exosomes and ectosomes possess different biological functions. However, little attention has been paid to the differential effects of EV subsets on cartilage regeneration. Methods Our study compared the effects of the two EVs isolated from adipose-derived MSCs (ASCs) on chondrocytes and bone marrow–derived MSCs (BMSCs) in vitro. Additionally, we loaded the two EVs into type I collagen hydrogels to optimize their application for the treatment of osteochondral defects in vivo. Results In vitro experiments demonstrate that ASC-derived exosomes (ASC-Exos) significantly promoted the proliferation and migration of both cells more effectively than ASC-derived ectosomes (ASC-Ectos). Furthermore, ASC-Exos facilitated a stronger differentiation of BMSCs into chondrogenic cells than ASC-Ectos, but both inhibited chondrocyte apoptosis to a similar extent. In the osteochondral defect model of rats, ASC-Exos promoted cartilage regeneration in situ better than ASC-Ectos. At 8 weeks, the hydrogel containing exosomes group (Gel + Exo group) had higher macroscopic and histological scores, a higher value of trabecular bone volume fraction (BV/TV), a lower value of trabecular thickness (Tb.Sp), and a better remodeling of extracellular matrix than the hydrogel containing ectosomes group (Gel + Ecto group). At 4 and 8 weeks, the expression of CD206 and Arginase-1 in the Gel + Exo group was significantly higher than that in the Gel + Ecto group. Conclusion Our findings indicate that administering ASC-Exos may be a more effective EV strategy for cartilage regeneration than the administration of ASC-Ectos.

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Section: Discussionmentioning

confidence: 99%

Comparison of the ability of exosomes and ectosomes derived from adipose-derived stromal cells to promote cartilage regeneration in a rat osteochondral defect model

Xu,

Yu,

et al. 2024

Stem Cell Res Ther

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“…Another candidate marker, C5AR1, is expressed in both myeloid cells and non-myeloid cells [36] and has been associated with increased recruitment and polarisation of macrophages to an M2 state in CRCLM and pancreatic cancer LM [29,[36][37][38]. The expression of TTYH3, another identified marker, has been associated with poor prognosis and poor response to immunotherapy in lung cancer [39] with high level of expression associated with immune cell infiltration, specifically macrophages and T-reg cells [39][40][41][42][43][44][45][46][47][48].…”

Section: Discussionmentioning

confidence: 99%

Circulating extracellular vesicles containing S100A9 reflect histopathology, immunophenotype and therapeutic responses of liver metastasis in colorectal cancer patients

Tsamchoe

Lazaris

Kim

et al. 2023

BJC Rep

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Background Metastasis is the principal cause of cancer treatment failure and an area of dire diagnostic needs. Colorectal cancer metastases to the liver (CRCLMs) are predominantly classified into desmoplastic and replacement based on their histological growth patterns (HGPs). Desmoplastic responds well to current treatments, while replacement HGP has a poor prognosis with low overall survival rates. Methods We hypothesised that complex cellular response underlying HGPs may be reflected in the proteome of circulating extracellular vesicles (EVs). EV proteomics data was generated through LC-MS/MS and analysed with Maxquant and Perseus. To validate the S100A9 signature, ELISA was performed, and IHC and IF were conducted on tissue for marker detection and colocalization study. Results Plasma EV proteome signature distinguished desmoplastic from the replacement in patients with 22 differentially expressed proteins, including immune related markers. Unsupervised PCA analysis revealed clear separation of the two lesions. The marker with the highest confidence level to stratify the two HGPs was S100A9, which was traced in CRCLM lesions and found to colocalize with macrophages and neutrophils. EV-associated S100A9 in plasma may reflect the innate immunity status of metastatic lesions and their differential therapeutic responses. Conclusion Plasma EV-derived S100A9 could be useful in personalising therapy in patients with CRCLM.

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TTYH3 promotes the malignant progression of oral squamous cell carcinoma SCC-9 cells by regulating tumor-associated macrophage polarization

Cao,

Zhou,

et al. 2024

Archives of Oral Biology

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TTYH3, a potential prognosis biomarker associated with immune infiltration and immunotherapy response in lung cancer

Cited by 6 publications

References 57 publications

Comparison of the ability of exosomes and ectosomes derived from adipose-derived stromal cells to promote cartilage regeneration in a rat osteochondral defect model

Comparison of the ability of exosomes and ectosomes derived from adipose-derived stromal cells to promote cartilage regeneration in a rat osteochondral defect model

Circulating extracellular vesicles containing S100A9 reflect histopathology, immunophenotype and therapeutic responses of liver metastasis in colorectal cancer patients

TTYH3 promotes the malignant progression of oral squamous cell carcinoma SCC-9 cells by regulating tumor-associated macrophage polarization

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