Tu-P7:25 Compound 48/80 promotes atherosclerotic plaque and intraplaque angiogenesis in apolipoprotein E deficient mice with carotid collar placement

Mast Cells as Effectors in Atherosclerosis

“…Interestingly, lack of mast cells was associated with a decrease in lesion size, which was described to be partly caused by reduced serum total cholesterol and triglyceride levels, and partly due to a reduction in vascular inflammation 23 . In line with these findings, activation of mast cells by the commonly used mast cell activator compound 48/80 induced atherosclerotic lesion development 24 , while treatment with cromolyn inhibited compound 48/80-induced mast cell activation and plaque progression 25 .…”

Mast cells: an expanding pathophysiological role from allergy to other disorders

“…In more recent studies, it was conclusively demonstrated that systemic mast cell activation aggravates the atherosclerotic lesion formation in apoE-deficient mice (Tang et al 2009) and mast cell stabilizers prevent this effect. Furthermore, it has also been shown that mast cell activation in perivascular tissue of advanced atherosclerosis in apoEdeficient mice leads to plaque instability, indicated by plaque hemorrhage, apoptosis and leukocyte recruitment (Guo et al 2009;Bot et al 2011).…”

CCL17 Controls Mast Cells for the Defense against Filarial Larval Entry

“…The total number of mast cells in the epidermis, dermis, and hypodermis was counted on 20 successive, complete fields of a light microscope (31000) per section and were averaged from 10 sections of each skin sample, which were separate from each other by five 4-mm sections that were not analyzed. Mast cells were classified as non-degranulated or degranulating (18). The examiner (J.K.F.)…”