Tu-P7:91 The assessment of minor myocardial damage in the critically ill patients

Čubrilo-Turek, Mirjana; Reiner, Željko; Duraković, Zijad; Turek, Stjepan

doi:10.1016/s1567-5688(06)80798-1

Cited by 2 publications

(2 citation statements)

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“…We excluded 513 studies after title and abstract screening and retrieved the re- maining 25 studies for further evaluation. Of the 25 retrieved studies, 6 were excluded (3 studies involved critically ill patients in the emergency department, burn center, or tertiary center specializing in postpartum hemorrhage, 17,23,29 2 studies were excluded because cTn measurements were not performed on all patients, 13,27 and 1 study 32 was excluded because it contained data from a study already included in our systematic review). Four additional studies identified through manual review of references met our inclusion criteria.…”

Section: Resultsmentioning

confidence: 99%

Elevated Cardiac Troponin Measurements in Critically Ill Patients

Lim

Qushmaq²,

Devereaux³

et al. 2006

Arch Intern Med

173

143

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Background:The clinical significance of elevated cardiac troponin (cTn) level in patients in the intensive care unit (ICU) is uncertain. We reviewed the frequency of cTn elevation and its association with mortality and length of ICU stay in these patients.Methods: Studies were identified using MEDLINE, EMBASE, and reference list review. We included observational studies of critically ill patients that measured cTn at least once and reported the frequency of elevated cTn or outcome (mortality and length of ICU or hospital stay). We pooled the odds ratios (ORs) using the inverse variance method in studies that conducted multivariable analysis to examine the relationship between elevated cTn and mortality (adjusted analysis). We calculated the weighted mean difference in length of stay between patients with and without elevated cTn and pooled the results using the inverse variance method (unadjusted analysis).Results: A total of 23 studies involving 4492 critically ill patients were included. In 20 studies, elevated cTn was found in a median of 43% (interquartile range, 21% to 59%) of 3278 patients. In adjusted analysis (6 studies comprising 1706 patients), elevated cTn was associated with an increased risk of death (OR, 2.5; 95% confidence interval [CI], 1.9 to 3.4; PϽ.001). In the unadjusted analysis (8 studies comprising 1019 patients), elevated cTn was associated with an increased length of ICU stay of 3.0 days (95% CI, 1.0 to 5.1 days; P=.004) and an increased length of hospital stay of 2.2 days (95% CI, −0.6 to 4.9; P=.12).Conclusions: Elevated cTn measurements among critically ill patients are associated with increased mortality and ICU length of stay. Research is needed to clarify the underlying causes of elevated cTn in this population and to examine their clinical significance.

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Section: Resultsmentioning

confidence: 99%

Elevated Cardiac Troponin Measurements in Critically Ill Patients

Lim

Qushmaq²,

Devereaux³

et al. 2006

Arch Intern Med

173

143

View full text Add to dashboard Cite

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“…CK is mainly distributed in skeletal muscle, followed by the myocardium. Its isoenzymes include CK-BB, CK-MB, CK-MM, and CK-Mt, and CK-MB is mainly expressed in the cytoplasm of the myocardium [ 24 ]. The isoenzymes of LDH include LDH1, LDH2, LDH3, LDH4, and LDH5, and the level of LDH1 in the myocardium is higher than the level of the other isoenzymes [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Citrulline on the Hearts of Rats with Sepsis Induced by Cecal Ligation and Puncture

Zhou

Xiong

Zhen

et al. 2018

BioMed Research International

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Purpose To investigate the protective effect of citrulline (Cit) on the hearts of rats with sepsis. Methods Wistar rats were divided into the normal, sham-operated, CLP, Cit, and CLP+Cit groups. Routine blood tests were performed, and the blood biochemical indexes were measured. Pathological changes in the cardiac tissues were observed. The levels of NO and iNOS in blood and SOD activity and MDA levels in the heart were measured. Results Less inflammatory cell infiltration of the myocardial fibers and significantly decreased white blood cell count, absolute neutrophil count, neutrophil percentage, CK, HBDH, and NO (all P<0.05) were detected in the CLP+Cit group compared with the CLP group. In addition, SOD activity and MDA levels in heart tissues were, respectively, higher and lower in the CLP+Cit group than in the CLP group (both P<0.05). Conclusions Cit reduces pathological damage in the heart and enhances the heart's antioxidant capacity, thereby protecting cardiomyocytes.

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Tu-P7:91 The assessment of minor myocardial damage in the critically ill patients

Cited by 2 publications

References 0 publications

Elevated Cardiac Troponin Measurements in Critically Ill Patients

Elevated Cardiac Troponin Measurements in Critically Ill Patients

Protective Effect of Citrulline on the Hearts of Rats with Sepsis Induced by Cecal Ligation and Puncture

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