Tu1350 Vedolizumab in the Treatment of IBD: The University of Chicago Experience

Christensen, Britt; Goeppinger, Sarah R.; Colman, Ruben J.; Siddiqui, Dania; Yarur, Andrés; Bochenek, Ashley A.; Wichmann, Alana; Hirsch, Ayal; Kinnucan, Jami; Sakuraba, Atsushi; Cohen, Russell D.; Rubin, David T.

doi:10.1016/s0016-5085(15)32937-1

Cited by 7 publications

(13 citation statements)

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“…This finding reflects current patterns of practice, particularly in CD, in which anti-TNF agents are generally used as first-line biological agents unless contraindications such as infective or malignant concerns exist. Indeed, the rate of prior anti-TNF exposure was as high as 87% in the Chicago cohort19 and higher still in the cohort recently reported by GETAID (Groupe d'Etude Therapeutique des Affections Inflammatoires du tube Digestif), with 99% of CD and 98% of patients with UC having previous exposure 20. These findings serve to demonstrate the refractory nature of the patients encountered at tertiary IBD referral centres.…”

Section: Discussionmentioning

confidence: 72%

“…Treatment outcomes were predefined as follows: clinical response was defined as a reduction of three or more in HBI or SCCAI, clinical remission was defined as HBI <5 or SCCAI <3. These definitions were based on their previously demonstrated (partial) validity25 26 and published post-marketing experiences of vedolizumab in an attempt to aid comparability of results 17 19…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Vedolizumab: early experience and medium-term outcomes from two UK tertiary IBD centres

Samaan

Pavlidis

Johnston

et al. 2016

Frontline Gastroenterol

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Section: Discussionmentioning

confidence: 72%

Section: Methodsmentioning

confidence: 99%

Vedolizumab: early experience and medium-term outcomes from two UK tertiary IBD centres

Samaan

Pavlidis

Johnston

et al. 2016

Frontline Gastroenterol

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“…A group from Chicago, IL, USA reported monocentric clinical effectiveness data for 42 CD and 27 UC patients. 37 Here 38.5% of their CD and 40% of their UC patients achieved clinical remission in week 14. They identified colon involvement and bio-na€ ıve patients as predictors for vedolizumab response.…”

Section: Discussionmentioning

confidence: 93%

“…None of their patients had achieved clinical remission by then, but Harvey–Bradshaw index and partial Mayo scores dropped significantly ( P < 0.01 vs. 0.05, respectively). A group from Chicago, IL, USA reported monocentric clinical effectiveness data for 42 CD and 27 UC patients . Here 38.5% of their CD and 40% of their UC patients achieved clinical remission in week 14.…”

Section: Discussionmentioning

confidence: 99%

Vedolizumab induction therapy for inflammatory bowel disease in clinical practice – a nationwide consecutive German cohort study

Baumgart

Bokemeyer

Drabik³

et al. 2016

Aliment Pharmacol Ther

172

141

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“…5 ; Figure S2) [ 34 , 40 , 60 , 69 ]. Of 46 studies reporting safety outcomes, most were for UC/CD combined, rather than by separate indication (Table S4) [ 13 , 18 , 20 , 24 , 26 , 27 , 31 , 32 , 37 , 38 , 40 – 42 , 44 – 46 , 53 , 55 , 56 , 58 , 59 , 61 , 64 – 68 , 70 – 74 , 78 – 80 , 84 , 89 , 91 – 95 , 97 , 98 , 102 , 104 – 109 ].…”

Section: Resultsmentioning

confidence: 99%

Systematic review with meta-analysis: real-world effectiveness and safety of vedolizumab in patients with inflammatory bowel disease

et al. 2018

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BackgroundSelective patient recruitment can produce discrepancies between clinical trial results and real-world effectiveness.MethodsA systematic literature review and meta-analysis were conducted to assess vedolizumab real-world effectiveness and safety in patients with ulcerative colitis (UC) or Crohn’s disease (CD). MEDLINE, MEDLINE In-Process, EMBASE, and Cochrane databases were searched for real-world studies of vedolizumab in adult patients with UC/CD reporting clinical response, remission, corticosteroid-free remission, UC/CD-related surgery or hospitalization, mucosal healing, or safety published from May 1, 2014–June 22, 2017. Response and remission rates were combined in random-effects meta-analyses.ResultsAt treatment week 14, 32% of UC patients [95% confidence interval (CI) 27–39%] and 30% of CD patients (95% CI 25–34%) were in remission; and at month 12, 46% for UC (95% CI 37–56%) and 30% for CD (95% CI 20–42%). For UC, the rates of corticosteroid-free remission were 26% at week 14 (95% CI 20–34%) and 42% at month 12 (95% CI 31–53%); for CD they were 25% at week 14 (95%, CI 20–31%) and 31% at month 12 (95%, CI 20–45%). At month 12, 33–77% of UC and 6–63% of CD patients had mucosal healing. Nine percent of patients reported serious adverse events.ConclusionsVedolizumab demonstrated real-world effectiveness in patients with moderate-to-severely active UC or CD, with approximately one-half and one-third of patients, respectively, in remission at treatment month 12. These findings are consistent with clinical trial data and support the long-term benefit–risk profile of vedolizumab.Electronic supplementary materialThe online version of this article (10.1007/s00535-018-1480-0) contains supplementary material, which is available to authorized users.

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Tu1350 Vedolizumab in the Treatment of IBD: The University of Chicago Experience

Cited by 7 publications

References 0 publications

Vedolizumab: early experience and medium-term outcomes from two UK tertiary IBD centres

Vedolizumab: early experience and medium-term outcomes from two UK tertiary IBD centres

Vedolizumab induction therapy for inflammatory bowel disease in clinical practice – a nationwide consecutive German cohort study

Systematic review with meta-analysis: real-world effectiveness and safety of vedolizumab in patients with inflammatory bowel disease

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