Tu1412 The Impact of Colonoscopy Preparation on Recommended Colonoscopy Screening Intervals in Average-Risk Screening Patients With No Polyps

Menees, Stacy B.; Elliott, Eric E.; Govani, Shail M.; Judd, Stephanie; Saini, Sameer D.; Anastassiades, Constantinos P.; Urganus, Annette L.; Schoenfeld, Philip

doi:10.1016/j.gie.2011.03.904

Cited by 1 publication

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“…When excellent/good bowel cleansing is compared to fair bowel cleansing, excellent/good bowel cleansing is associated with higher polyp detection rates and greater likelihood of being appropriately instructed to repeat colonoscopy at 10-year intervals after a normal screening colonoscopy(5, 12). Secondary endpoints compared MiraLAX® + Gatorade + bisacodyl-treated patients to patients treated with 4L GoLytely® for: (a) comparison of frequency of excellent, good, fair, and poor bowel cleansing; (b) frequency of receiving a recommendation to repeat colonoscopy at 10-year intervals after a normal screening colonoscopy; and (c) frequency of serious adverse events.…”

Section: Methodsmentioning

confidence: 99%

MiraLAX-Gatorade Bowel Prep Versus GoLytely Before Screening Colonoscopy

Gunaratnam

Mohamud

Schoenfeld

2012

Journal of Clinical Gastroenterology

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Background Polyethylene Glycol-3350 without electrolytes (MiraLAX®; Schering-Plough Healthcare Products Inc.) + a carbohydrate-electrolyte solution (Gatorade; PepsiCo Inc.) + bisacodyl is frequently used for bowel cleansing, although limited data quantifies its efficacy and safety. No prior studies have assessed this in a community setting or with PM-only dosing, which is still used frequently. Aim To compare the frequency of excellent/good/fair/poor bowel cleansing with PM-only dosing of MiraLAX®-Gatorade-bisacodyl vs. 4L GoLytely®. Methods This is a retrospective endoscopic database analysis of ≥ 50 year old average-risk individuals with a normal screening colonoscopy at a community hospital and ambulatory endoscopy center. Data was extracted for the last four months when 4L GoLytely® was the preferred bowel purgative and the first 4 months when 238g MiraLAX® in 64 ounces Gatorade and four 5-mg bisacodyl tablets became the preferred purgative. All patients used PM-only dosing of bowel purgative. Results 778 subjects [GoLytely® (n=395) vs. MiraLAX® + Gatorade + bisacodyl (n=383)] were identified. Patients who took the MiraLAX® bowel preparation were more likely to achieve an excellent/good bowel cleansing compared to patients taking the GoLytely® preparation (93.3% vs. 89.3%, respectively; p = 0.048). However, when only ASA Class I patients are studied, there was no difference in frequency of excellent/good bowel cleansing (91.1% vs 93.6%, respectively; p = 0.498). No serious adverse events were identified. An excellent/good bowel cleansing was strongly associated with a recommendation for repeat colonoscopy in 10 years compared to patients with a fair cleansing [OR = 28.01; 95% CI: 13.96-56.19]. Conclusions The MiraLAX® + Gatorade + bisacodyl combination produces similar rates of excellent/good bowel cleansing as compared to GoLytely® in most average-risk individuals undergoing colonoscopy for CRC screening in a community setting.

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Section: Methodsmentioning

confidence: 99%