Tu1423: THE CROHN'S DISEASE EXCLUSION DIET (CDED) FOR POUCH INFLAMMATION: AN INTERVENTIONAL PILOT STUDY

Isakov, Naomi Fliss; Kornblum, Jasmine; Ginat, Tamar; Zemel, Meir; Hirsch, Ayal; Maharshak, Nitsan

doi:10.1016/s0016-5085(22)62261-3

Cited by 2 publications

(8 citation statements)

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“…Finally, seven studies journals.sagepub.com/home/tag TherapeuTic advances in Gastroenterology were included in the analysis. Isakov et al 18 examined the effectiveness of CDED on clinical remission in patients with pouch inflammation, which was included in the review because of the similarities between the pathogenesis of pouchitis and CD. Details on included studies and selection process are shown in the PRISMA flowchart on Figure 1.…”

Section: Overview Of the Study Selectionmentioning

confidence: 99%

“…A total of seven studies that investigated the effectiveness of CDED on CD remission were included in this systematic review. Five of these studies were conducted in Israel 10,12,14,18,19 , one in Israel and Canada, 10 and two in Poland. 20,21 With regard to the study design, two of these studies were RCTs 10,12 whereas five were prospective nonrandomized studies.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…20,21 With regard to the study design, two of these studies were RCTs 10,12 whereas five were prospective nonrandomized studies. 14,[18][19][20][21] Two studies targeted children, 10,21 , three targeted adults. 12,18,20 Sigall et al 14,19 included both adults and children.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…14,[18][19][20][21] Two studies targeted children, 10,21 , three targeted adults. 12,18,20 Sigall et al 14,19 included both adults and children. The seven studies involved a total of 277 patients, with sample sizes ranging from 15 to 74 patients.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…12 One study used clinical perianal disease activity index (cPDAI) and modified perianal disease activity index (mPDAI) to assess disease activity in adults with pouchitis. 18 Additionally, all studies used normalization of inflammatory markers, referred to C-reactive protein (CRP), and fecal calprotectin (FCP) level. Erythrocyte sedimentation rate (ESR) and simplified endoscopic activity score for Crohn's disease (SES-CD) were also used as secondary outcome measures of remission.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Effects of Crohn’s disease exclusion diet on remission: a systematic review

Zhu,

Lei,

Lin

2023

Therap Adv Gastroenterol

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Background: Dietary therapy may potentially reduce inflammation and promote mucosal healing in patients with Crohn’s disease and is associated with fewer side effects and lower cost compared to medical therapy. Recently the Crohn’s disease exclusion diet (CDED) has been developed to reduce exposure to individualized dietary components which negatively affect the intestine in patients with Crohn’s disease. Objectives: This systematic review aimed to explore the effectiveness of CDED in Crohn’s disease patients. Design: A systematic review Data sources and methods: A systematic search was performed on the PubMed, EBSCOhost, Cochrane library, OVID, Embase, Scopus, and CINHAL to identify relevant clinical trials published from 1 January 2014 to 31 August 2022. Results: A total of 1120 studies were identified and 7 studies were finally included in the analysis. The study was reported according to Preferred Reporting Items for Systematic Reviews and Meta-analysis statement. Conclusion: Our findings suggested that the use of CDED seemed to be effective for induction and maintenance of remission in children and adults with mild to moderate Crohn’s disease. However, heterogeneity and limitations existed among the studies included. Further investigation in the form of well-designed randomized clinical trials is needed to validate the present findings. Registration: PROSPERO registration number CRD42022335453.

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Section: Overview Of the Study Selectionmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Effects of Crohn’s disease exclusion diet on remission: a systematic review

Zhu,

Lei,

Lin

2023

Therap Adv Gastroenterol

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Dietary Interventions and Supplementation in Patients With an Ileal Pouch–Anal Anastomosis: A Systematic Review

Gold,

Levinson,

Colombel

et al. 2024

Inflammatory Bowel Diseases

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Lay Summary The restorative proctocolectomy with ileal pouch–anal anastomosis is the preferred surgery for patients with medically refractory ulcerative colitis. Although the ileal pouch–anal anastomosis provides gastrointestinal continuity and is an excellent alternative to a permanent end ileostomy, it is not without its complications including acute pouchitis, which occurs in up to 80% of patients. Diet may have a significant impact on pouch function and the development of pouchitis by virtue of its impact on motility and the microbiome. Multiple studies have evaluated the ability of different diets and supplements to improve pouch function and manage pouchitis, yet results are conflicting; thus, evidence-based dietary recommendations are lacking. Patients with an ileoanal pouch routinely ask about dietary interventions to maintain pouch health, and it is crucial that concrete evidence-based recommendations are identified to provide guidance. The goal of this systematic review is to summarize the available data on dietary patterns in patients with an ileoanal pouch, dietary interventions in this cohort, and the impact of supplements on pouch function and pouchitis.

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Tu1423: THE CROHN'S DISEASE EXCLUSION DIET (CDED) FOR POUCH INFLAMMATION: AN INTERVENTIONAL PILOT STUDY

Cited by 2 publications

References 0 publications

Effects of Crohn’s disease exclusion diet on remission: a systematic review

Effects of Crohn’s disease exclusion diet on remission: a systematic review

Dietary Interventions and Supplementation in Patients With an Ileal Pouch–Anal Anastomosis: A Systematic Review

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