Tu2053 – Inflammatory Bowel Disease in Cystic Fibrosis: is It More Prevalent?

Kesler, Alex M.; Kröner, Paul T.; Abader, Peter; Afsh, Mohammad; Lewis, Michele D.

doi:10.1016/s0016-5085(19)39928-7

Cited by 1 publication

(4 citation statements)

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“…Figure 1 depicts the flowchart for the selection process. In the end, 20 reports were eligible for inclusion [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ], 15 of which reporting the biopsy-verified prevalence or seroprevalence of CeD were included in the quantitative synthesis [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ].…”

Section: Resultsmentioning

confidence: 99%

“…In this paper, out of 60,000 CF patients, IBD prevalence was 0.81% (CI 0.74–0.88%), in contrast to 0.3% prevalence in the non-CF population [ 69 ]. Crohn’s disease and ulcerative colitis had a prevalence of 0.63% (CI 0.57–0.70%) and 0.17% (CI 0.14–0.21%), respectively [ 44 ]. We must note that these data came from a multi-center survey without exact details on diagnostic strategies and therefore should be treated with caution.…”

Section: Discussionmentioning

confidence: 99%

“…Figure 1 depicts the flowchart for the selection process. In the end, 20 reports were eligible for inclusion [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48], 15 of which reporting the biopsy-verified prevalence or seroprevalence of CeD were included in the quantitative synthesis [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43].…”

Section: Search and Selectionmentioning

confidence: 99%

“…Kesler et al conducted a propensity-matched case-control study, including 60,055 CF patients from an ICD coding-based inpatient registry in the United States. A total of 380 suffered from Crohn's disease, and 105 patients had ulcerative colitis [44]. Further, seven studies reported only nine cases of Crohn's disease and seven cases of ulcerative colitis in total [30,32,36,37,[45][46][47].…”

Section: Systematic Review On Autoimmune Diseases Other Than Celiac Diseasementioning

confidence: 99%

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Increased Prevalence of Celiac Disease in Patients with Cystic Fibrosis: A Systematic Review and Meta-Analysis

Imrei

Németh

Szakács

et al. 2021

JPM

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Objectives: Immune regulation seems to be altered in cystic fibrosis (CF), thus potentially predisposing patients to developing autoimmune diseases (AID). In this meta-analysis, we aimed to evaluate the prevalence of celiac disease (CeD) among CF patients as by far the most commonly reported autoimmune disease in this population and, secondly, to review the observations on other, less frequently studied autoimmune diseases. Methods: We conducted a systematic literature search for studies that discussed AIDs among CF patients. Following standard selection and data collection, we calculated pooled raw prevalence with 95% confidence intervals (CI) for biopsy-verified CeD and seropositivity. Results: Out of the 21 eligible studies, 15 reported on CeD. Pooled prevalence of biopsy-verified CeD was 1.8% (CI 1.1–2.7%) according to a homogeneous dataset from six prospective, consecutive screening studies, while it proved to be 2.3% (CI 1.1–4.7%) according to a heterogeneous dataset from the other studies. Tissue transglutaminase IgA positivity was detected in 4.5% of CF cases (CI 2.8–6.9%), while tissue transglutaminase IgA–endomysial antibody IgA double positivity was found in 2.4% of them (CI 1.5–3.9%). Findings on other AIDs were strongly limited. Conclusions: The pooled prevalence of CeD in CF seemed to be more than twice as high compared to the global prevalence; therefore, routine screening of CeD could be considered in CF.

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