Tualang Honey: Composition, Physiochemical Properties and Clinical Importance

Mohamed, Zenab B. Hamad; Alfarisi, Hamad Abdulsalam Hamad

doi:10.7897/2230-8407.089150

Cited by 6 publications

(12 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The bead was prepared based on the method of Muhammed et al [6]. Vitamin C (1, 3 and 5% total excipient) was mixed with a combined solution of glucomannan and alginate in certain ratio (100 ml, 3%) was prepared.…”

Section: Bead Preparation Methodsmentioning

confidence: 99%

“…This higher positive charged decreased the electrical repulsion between negatively charged alginate molecules and resulted transformation of alginate into an insoluble form of alginic acid. This condition reduced penetration of solvent during solubility determination [6]. Moreover, combination of glucomannan and alginate decreased solubility.…”

Section: Solubilitymentioning

confidence: 99%

“…Moreover, combination of glucomannan and alginate decreased solubility. Mohamed et al [6] reported this combination led to synergistic interaction between these polymers hence enhance the stability of the bead. As a result, lower solubility was observed in the mixed excipient.…”

Section: Solubilitymentioning

confidence: 99%

“…Bead swelling and solubility were determined based on the method of Muhammed et al [6] in two solutions i.e. 0.1M HCl (pH 1.2) and pH 6.8 of phosphate buffer (0.1M).…”

Section: Swelling and Solubilitymentioning

confidence: 99%

“…It forms beads through ionotropic gelation in divalent cation solution. This unique property has attracted researchers to use it as drug carrier [6]. However, its instability in the acidic environment [7] and its porosity [8] limit alginate application as a drug matrix.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Physicochemical Properties of Glucomannan-Alginate as Vitamin C Excipient

Wardhani¹,

Hapsari²,

Suryana³

et al. 2018

Evergreen

View full text Add to dashboard Cite

This work investigated the physicochemical properties of glucomannan-alginate combination as an excipient of vitamin C encapsulation. The effects of glucomannan-alginate ratio, concentration of vitamin C and preparation method on the encapsulation physicochemical properties were studied. Swelling and solubility of the vitamin C encapsulation were determined in 2 pH conditions which mimic the environment pH of the stomach and the lower gastrointestinal tract. The ratio of glucomannan-alginate on swelling at both pHs had a similar impact on the solubility. Higher values of swelling and solubility were observed at pH 6.8 than those at pH 1.2. The second method preparation of 1:1 (w/w) ratio of glucomannan-alginate showed the most soluble excipient in pH 6.8. The highest viscosity was observed at encapsulation of 3% vitamin C prepared using the second method of 3:1 (w/w) of glucomannan-alginate.

show abstract

Section: Bead Preparation Methodsmentioning

confidence: 99%

Section: Solubilitymentioning

confidence: 99%

Section: Solubilitymentioning

confidence: 99%

“…Bead swelling and solubility were determined based on the method of Muhammed et al [6] in two solutions i.e. 0.1M HCl (pH 1.2) and pH 6.8 of phosphate buffer (0.1M).…”

Section: Swelling and Solubilitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Physicochemical Properties of Glucomannan-Alginate as Vitamin C Excipient

Wardhani¹,

Hapsari²,

Suryana³

et al. 2018

Evergreen

View full text Add to dashboard Cite

show abstract

Protective effect of Tualang honey against cadmium-induced morphological abnormalities and oxidative stress in the ovary of rats

Ruslee

Zaid

Bakrin

et al. 2020

BMC Complement Med Ther

View full text Add to dashboard Cite

Background: To investigate the protective effects of Tualang honey against the toxicity effects induced by cadmium (Cd) on the ovary. Methods: A total of 32 female Sprague Dawley rats were taken and randomly divided into four groups (n = 8). Throughout the experimental period of 6 weeks, negative control-NC (vehicle deionized water), positive control-CD (Cd at 5 mg/kg), Tualang honey followed by Cd exposure-TH (Tualang honey at 200 mg/kg and Cd at 5 mg/kg) and Tualang honey control-THC (Tualang honey at 200 mg/kg) groups, were administered orally on a daily basis. Results: Rats exposed to Cd were significantly higher in ovarian weight, number of antral and atretic follicles as compared to the NC group. The disruptive effects of Cd on ovarian follicles were associated with a disruption in gonadotropin hormones and decreases in follicular stimulating hormone (FSH) and luteinizing hormone (LH). Moreover, a significant formation of oxidative stress in ovarian Cd-exposed rats has been proven by increasing the level of lipid peroxidation products (malondialdehyde) and decreasing the levels of enzymatic antioxidant (catalase). Interestingly, a daily supplementation of high antioxidant agents such as Tualang honey in these animals, caused significant improvements in the histological changes. Additionally, less atretic follicles were observed, restoring the normal level of LH and FSH (P < 0.001), and normalizing the ovarian malondialdehyde (P < 0.05) and catalase levels in comparison with CD group (P < 0.05). Conclusions: Tualang honey has protective effects against Cd-induced ovarian toxicity by reducing morphological abnormalities, restoring the normal levels of gonadotropin hormones and stabilizing equilibrium levels of lipid peroxidation and antioxidant enzyme in ovaries of rats.

show abstract

The Effect of Administering Forest Honey to Rats Exposed to Physical Stress on Corticosteroid Levels, Folliculogenesis and the Number of Corpus Luteum

Widjiati,

Kuntjorodjakti,

Ananda

et al. 2023

Biomed. Pharmacol. J.

View full text Add to dashboard Cite

Livestock that has stress releases glucocorticoids in response to it, and it causes inhibition of the hypothalamus-pituitary-gonadal axis (HPG) signaling pathway so that it reduces reproductive efficiency. Forest honey can reduce corticosteroid levels as a stress response from physical stress induction which is expected to increase reproductive efficiency including folliculogenesis and the formation of the corpus luteum. This study aims to determine the effect of forest honey on rats (Rattus novergicus) exposed to physical stress on corticosteroid levels, folliculogenesis, and the number of corpus luteum. This study is an experimental laboratory one using 32 rats which were divided into 4 treatment groups; control positive (C) treated with physical stress, treatment 1 (T1) treated with physical stress + honey 2 g/rat/day PO, treatment 2 (T2) treated with physical stress + honey 4 g/rat/day PO and treatment 3 (T3) treated with physical stress + honey 6 g/rat/day PO. All treatments were carried out for 14 days. The results showed that T1 had the lowest corticosteroid level compared to all treatment groups and the corticosteroid level of this group was significantly different (p <0.05) compared to that of C and T3. The folliculogenesis profile showed that the number of primary secondary, tertiary, and Graafian follicles of group T1 was significantly different (p<0.05) compared to that of C, T2, and T3. In terms of the number of corpus luteum, it showed that T1 had the highest number of corpus luteum, and the number of corpus luteum in this group was significantly different (p<0.05) from that of C, T2, and T3. It can be concluded that the administration of forest honey at a dose of 2g/rat/day could reduce corticosteroid levels, improve the folliculogenesis profile, and increase the number of corpus luteum in rats exposed to physical stress. The use of forest honey could reduce corticosteroid levels as a stress response from physical stress induction which was expected to increase reproductive efficiency.

show abstract

Tualang Honey: Composition, Physiochemical Properties and Clinical Importance

Cited by 6 publications

References 23 publications

Physicochemical Properties of Glucomannan-Alginate as Vitamin C Excipient

Physicochemical Properties of Glucomannan-Alginate as Vitamin C Excipient

Protective effect of Tualang honey against cadmium-induced morphological abnormalities and oxidative stress in the ovary of rats

The Effect of Administering Forest Honey to Rats Exposed to Physical Stress on Corticosteroid Levels, Folliculogenesis and the Number of Corpus Luteum

Contact Info

Product

Resources

About