Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure

Tang, Suk Peng; Salam, Sirajudeen Kuttulebbai Nainamohamed; Jaafar, Hasnan; Gan, Siew Hua; Mustapha, Muzaimi; Sulaiman, Siti Amrah

doi:10.1155/2017/4605782

Cited by 19 publications

(12 citation statements)

References 77 publications

(81 reference statements)

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“…In addition, honey has been reported to reduce brain oxidative stress and improve morphological impairment of the hippocampus and medial prefrontal cortex in stressed rats [50][51][52][53][54][55]. Honey also attenuates the cognitive impairment caused by chronic cerebral hypoperfusion-induced neurodegeneration [56] and ameliorates oxidative stress in the rat midbrain against repeated paraquat exposure [57]. Meanwhile, in normal rats, consumption of honey could prevent morphological impairment of the hippocampus and improve the spatial memory performance of adult male rats [58].…”

Section: Neuroprotective Activities Of Natural Products and Their Biomentioning

confidence: 99%

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Sairazi

Sirajudeen

2020

Evidence-Based Complementary and Alternative Medicine

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142

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In recent years, natural products, which originate from plants, animals, and fungi, together with their bioactive compounds have been intensively explored and studied for their therapeutic potentials for various diseases such as cardiovascular, diabetes, hypertension, reproductive, cancer, and neurodegenerative diseases. Neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by the progressive dysfunction and loss of neuronal structure and function that resulted in the neuronal cell death. Since the multifactorial pathological mechanisms are associated with neurodegeneration, targeting multiple mechanisms of actions and neuroprotection approach, which involves preventing cell death and restoring the function to damaged neurons, could be promising strategies for the prevention and therapeutic of neurodegenerative diseases. Natural products have emerged as potential neuroprotective agents for the treatment of neurodegenerative diseases. This review focused on the therapeutic potential of natural products and their bioactive compounds to exert a neuroprotective effect on the pathologies of neurodegenerative diseases.

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Section: Neuroprotective Activities Of Natural Products and Their Biomentioning

confidence: 99%

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Sairazi

Sirajudeen

2020

Evidence-Based Complementary and Alternative Medicine

Self Cite

142

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“…A recent study reported that in female athletes, Tualang honey showed antioxidant activity and oxidative stress in a dose-dependent manner. 67 Tualang honey was also found to protect the rat midbrain from oxidative stress 68 . Azman et al 27,69 demonstrated that Tualang honey prevented memory deficits following noise stress.…”

Section: Reported Thatmentioning

confidence: 99%

Tualang Honey Ameliorates Hypoxia-induced Memory Deficits by Reducing Neuronal Damage in the Hippocampus of Adult Male Sprague Dawley Rats

Qaid

Zakaria

Yusof

et al. 2020

tjps

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INTRODUCTION: A growing body of evidence indicates that hypoxia exposure causes learning and memory deficits. Effective natural therapeutic approach has, however, not been explored widely. Our previous studies found that Tualang honey administration protected learning and memory functions in ovariectomised rats. Therefore, the present study investigated its efficacy in ameliorating hypoxia-induced memory deficits in adult male Sprague-Dawley rats. METHODS: The rats were divided into four groups; i) Normoxia treated with sucrose (n=12), ii) Normoxia treated with Tualang honey (n=12), iii) Hypoxia treated with sucrose (n=12), and iv) Hypoxia treated with Tualang honey (n=12). Tualang honey (0.2 g/kg/BW) and sucrose (1 mL of 7.9%) supplementations were administered orally to the rats daily for 14 days. Then, hypoxia groups were exposed to hypoxia (~11%) for 7 days while normoxia groups were kept in normal condition. Following exposure to hypoxia, rats memory were analyzed using novel object recognition task and T-maze test. RESULTS: The data revealed that rats exposed to hypoxia showed significant impairment in short-term memory (STM), spatial memory (p<0.01) and long term memory (LTM) when compared to the normoxia group. Hypoxia rats treated with Tualang honey showed significant improvement in STM, LTM and spatial memory (p<0.05) as compared with hypoxia treated with sucrose (p<0.05). Tualang honey also reduced neuronal damage in hippocampus of adult male Sprague-Dawley rats exposed to hypoxia. DISCUSSION AND CONCLUSION: Therefore, it is suggested that Tualang honey pretreatment has protective effects against hypoxia-induced memory deficits, possibly through its antioxidant contents.

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“…Many studies reported the beneficial effect of TH including antioxidant effect in diabetic rats [ 37 ], protective effect in animal model of menopause [ 38 ], and cigarette smoke-induced damage in rat male reproductive system [ 39 ], and also in the management of wound-healing [ 40 ]. In addition, the neuroprotective effect of TH has been previously reported attenuating the cognitive impairment caused by chronic cerebral hypoperfusion-induced neurodegeneration [ 41 ] and ameliorating oxidative stress in the rat midbrain against repeated paraquat exposure [ 42 ]. TH supplementation also improved the hippocampus and medial prefrontal cortex morphological impairment in stressed ovariectomized rats [ 43 , 44 ] and reduced the brain oxidative stress and improved memory performances in rats exposed to noise stress [ 45 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

Tualang Honey Reduced Neuroinflammation and Caspase‐3 Activity in Rat Brain after Kainic Acid‐Induced Status Epilepticus

Sairazi

Sirajudeen

Mustapha

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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The protective effect of tualang honey (TH) on neuroinflammation and caspase-3 activity in rat cerebral cortex, cerebellum, and brainstem after kainic acid- (KA-) induced status epilepticus was investigated. Male Sprague-Dawley rats were pretreated orally with TH (1.0 g/kg body weight) five times at 12 h intervals. KA (15 mg/kg body weight) was injected subcutaneously 30 min after last oral treatment. Rats were sacrificed at 2 h, 24 h, and 48 h after KA administration. Neuroinflammation markers and caspase-3 activity were analyzed in different brain regions 2 h, 24 h, and 48 h after KA administration. Administration of KA induced epileptic seizures. KA caused significant (p < 0.05) increase in the level of tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), glial fibrillary acidic protein (GFAP), allograft inflammatory factor 1 (AIF-1), and cyclooxygenase-2 (COX-2) and increase in the caspase-3 activity in the rat cerebral cortex, cerebellum, and brainstem at multiple time points. Pretreatment with TH significantly (p < 0.05) reduced the elevation of TNF-α, IL-1β, GFAP, AIF-1, and COX-2 level in those brain regions at multiple time points and attenuated the increased caspase-3 activity in the cerebral cortex. In conclusion, TH reduced neuroinflammation and caspase-3 activity after kainic acid- (KA-) induced status epilepticus.

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Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure

Cited by 19 publications

References 77 publications

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Tualang Honey Ameliorates Hypoxia-induced Memory Deficits by Reducing Neuronal Damage in the Hippocampus of Adult Male Sprague Dawley Rats

Tualang Honey Reduced Neuroinflammation and Caspase‐3 Activity in Rat Brain after Kainic Acid‐Induced Status Epilepticus

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