TuBaFrost 1: Uniting local Frozen Tumour Banks into a European Network: an overview

Riegman, Peter; Dinjens, Winand N.M.; Oomen, M.H.A.; Spatz, Alan; Ratcliffe, Chris; Knox, Kirstine A.; Mager, R.; Kerr, David; Pezzella, Francesco; Damme, B Van; Vijver, Marc J. van de; Boven, Hester van; Morente, Manuel; Alonso, Soledad; Kerjaschki, Dontscho; Pammer, Johannes; Löpez‐Guerrero, José Antonio; Bosch, Antonio Llombart; Carbone, Antonino; Gloghini, Annunziata; Teodorović, Ivana; Isabelle, Maripier; Jaminé, D.; Passioukov, A.; Lejeune, S.; Therasse, Patrick; Veen, Evert-Ben van; Lam, King H.; Oosterhuis, J. Wolter

doi:10.1016/j.ejca.2006.04.031

Cited by 39 publications

(16 citation statements)

References 13 publications

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“…To overcome these challenges and reach the goals, the public and private domains must join forces. Various models have been proposed for uniting tissue banks into a network, such as the consortium of the European network for frozen tumour banks, TubaFrost Morente et al 2004Morente et al , 2006Riegman et al 2006) and the European Network of psychiatric brain banks (Schmitt et al 2007). …”

Section: Recommendationsmentioning

confidence: 99%

Standard Operating Procedures, ethical and legal regulations in BTB (Brain/Tissue/Bio) banking: what is still missing?

Ravid¹

2007

Cell Tissue Banking

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The use of human biological specimens in scientific research is the focus of current international public and professional concern and a major issue in bioethics in general. Brain/Tissue/Bio banks (BTB-banks) are a rapid developing sector; each of these banks acts locally as a steering unit for the establishment of the local Standard Operating Procedures (SOPs) and the legal regulations and ethical guidelines to be followed in the procurement and dissemination of research specimens. An appropriat Code of Conduct is crucial to a successful operation of the banks and the research application they handle. What are we still missing ? (1) Adequate funding for research BTB-banks. (2) Standard evaluation protocls for audit of BTB-bank performance. (3) Internationally accepted SOP's which will facilitate exchange and sharing of specimens and data with the scientific community. (4) Internationally accepted Code of Conduct. In the present paper we review the most pressing organizational, methodological, medico-legal and ethical issues involved in BTB-banking; funding, auditing, procurement, management/handling, dissemination and sharing of specimens, confidentiality and data protection, genetic testing, "financial gain" and safety measures. Taking into consideration the huge variety of the specimens stored in different repositories and the enormous differences in medico-legal systems and ethics regulations in different countries it is strongly recommend that the health-care systems and institutions who host BTB-Banks will put more efforts in getting adequate funding for the infrastructure and daily activities. The BTB-banks should define evaluation protocols, SOPs and their Code of Conduct. This in turn will enable the banks to share the collected specimens and data with the largest possible number of researchers and aim at a maximal scientific spin-off and advance in public health research.

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Section: Recommendationsmentioning

confidence: 99%

Standard Operating Procedures, ethical and legal regulations in BTB (Brain/Tissue/Bio) banking: what is still missing?

Ravid¹

2007

Cell Tissue Banking

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“…There are numerous reports about successful fresh frozen tissue banks that are run by institutes of pathology in academic centers [7][8][9][14][15][16]. Collaborative networks of these institutions have been founded since the 1990s, such as the Cooperative Human Tissue Network (CHTN) run by the National Cancer Institute in the United States, or the TuBaFrost initiative connecting large local European fresh frozen tissue collections in academic institutions in Spain, The Netherlands, Belgium, United Kingdom, Austria, and France [9,10]. One major advantage of fresh frozen tissue banking in a midsized regional hospital is the composition of the study population.…”

Section: Discussionmentioning

confidence: 99%

Tissue Banking in a Regional Hospital: A Promising Future Concept? First Report on Fresh Frozen Tissue Banking in a Hospital Without an Integrated Institute of Pathology

Torney¹,

Güller

Rezaeian

et al. 2012

World j. surg.

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Background Vital tissue provided by fresh frozen tissue banking is often required for genetic tumor profiling and tailored therapies. However, the potential patient benefits of fresh frozen tissue banking are currently limited to university hospitals. The objective of the present pilot study-the first one in the literature-was to evaluate whether fresh frozen tissue banking is feasible in a regional hospital without an integrated institute of pathology. Methods Patients with resectable breast and colon cancer were included in this prospective study. Both malignant and healthy tissue were sampled using isopentan-based snap-freezing 1 h after tumor resection and stored at -80°C before transfer to the main tissue bank of a University institute of pathology. Results The initial costs to set up tissue banking were 35,662 US$. Furthermore, the running costs are 1,250 US$ yearly. During the first 13 months, 43 samples (nine samples of breast cancer and 34 samples of colon cancer) were collected from 41 patients. Based on the pathology reports, there was no interference with standard histopathologic analyses due to the sample collection. Conclusions This is the first report in the literature providing evidence that tissue banking in a regional hospital without an integrated institute of pathology is feasible. The interesting findings of the present pilot study must be confirmed by larger investigations.

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“…The current achievement of TBP in Spain will only continue to work with strong ethical and quality standards, and will also depend on the use of TBP samples for projects of excellence. Our 'network of networks' functional model could be useful for other countries and/or international tumour bank activities [9,10] .…”

Section: Future Goals and Perspectivesmentioning

confidence: 99%

Tumour Banking: The Spanish Design

2007

Self Cite

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In Spain, as in most developed countries, a large number of private or public institutions keep biorepositories of human tumour samples. In fact, most of the currently accepted oncological entities were described in the 20th century by a clinical-pathological approach based on the study of tumours collected through collaborations between clinicians and pathologists. In parallel, and almost without effective connections with the clinical setting, basic researchers have produced a plethora of data, focusing on the main cancer basic mechanisms which mostly use cell lines and animal models.The last decade of the 20th century was the scenario of a biotechnological revolution, characterised not only by new methods for genomic and proteomic studies but also by being able to effectively and efficiently transfer this technology to many research centres in the developed world as well as to its clinical setting. These technical developments have renewed the need for high-quality tissue samples, especially in an era when this technology is of increasing clinical value to [1-3] :• Identify new parameters of clinical value, therefore demanding large-scale molecular studies with large numbers of cases.• Transfer knowledge from basic to clinical research, which requires homogeneous tissue-sampling protocols for multi-centre studies.• Confirm results obtained in the animal models and human cell lines, which requires providing human samples of clinical origin to basic research groups. Key WordsBiobank ؒ Biorepository ؒ Tumour bank ؒ Tumour bank network ؒ Translational research AbstractIn the last decade the technical advances in high throughput techniques to analyze DNA, RNA and proteins have had a potential major impact on prevention, diagnosis, prognosis and treatment of many human diseases. Key pieces in this process, mainly thinking about the future, are tumour banks and tumour bank networks. To face these challenges, diverse suitable models and designs can be developed. The current article presents the development of a nationwide design of tumour banks in Spain based on a network of networks, specially focusing on its harmonization efforts mainly regarding technical procedures, ethical requirements, unified quality control policy and unique sample identification. We also describe our most important goals for the next years. This model does not correspond to a central tumour bank, but to a cooperative and coordinated network of national and regional networks. Independently from the network in which it is included, sample collections reside in their original institution, where it can be used for further clinical diagnosis, teaching and research activities of each independent hospital. The herein described 'network of networks' functional model could be useful for other countries and/or international tumour bank activities.

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TuBaFrost 1: Uniting local Frozen Tumour Banks into a European Network: an overview

Cited by 39 publications

References 13 publications

Standard Operating Procedures, ethical and legal regulations in BTB (Brain/Tissue/Bio) banking: what is still missing?

Standard Operating Procedures, ethical and legal regulations in BTB (Brain/Tissue/Bio) banking: what is still missing?

Tissue Banking in a Regional Hospital: A Promising Future Concept? First Report on Fresh Frozen Tissue Banking in a Hospital Without an Integrated Institute of Pathology

Tumour Banking: The Spanish Design

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