Tubal Ligation and Incidence of 26 Site-Specific Cancers in the Million Women Study

Gaitskell, Kezia; Coffey, Kate; Green, Jane; Pirie, Kirstin; Reeves, Gillian; Ahmed, Ahmed A.; Barnes, Isobel; Beral, Valerie

doi:10.1097/01.ogx.0000525563.08750.03

Search citation statements

Order By: Relevance

Paper Sections

Select...

Lessons From Bilateral Tubal Ligation and Other Interventions1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2017

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The association between bilateral tubal ligation (BTL) and a decreased risk of ovarian cancer is well established, resulting in an overall 20% to 40% lower rate of EOC in women after BTL. [33][34][35][36][37][38] The impact of BTL appears to be greatest on endometriosis-associated histologies, such as clear cell and endometrioid carcinomas, 39 and this may shed light on the mechanism of protection.…”

Section: Lessons From Bilateral Tubal Ligation and Other Interventionsmentioning

confidence: 99%

Risk‐reducing salpingectomy: Let us be opportunistic

Roche

Abu‐Rustum

Nourmoussavi

et al. 2017

Cancer

View full text Add to dashboard Cite

As there is no screening test for ovarian cancer, effective prevention strategies may be the best way to reduce the mortality of this most lethal gynecologic malignancy. Increasing evidence supports the hypothesis that the fallopian tube is the site of origin for the vast majority of high-grade serous carcinomas. Our growing understanding of the pathogenesis of this disease offers a rare opportunity to explore new preventive measures such as bilateral salpingectomy, which may provide great benefit without compromising ovarian function. If the tubal paradigm is accurate, the impact of bilateral salpingectomy could extend to BRCA1 and BRCA2 mutation carriers, high-risk non-carriers, and average-risk women. We present a review of the literature on the role of risk-reducing salpingectomy in all women and in high-risk groups, with a focus on morbidity, ovarian function, potential clinical applicability, and epidemiological considerations.

show abstract