Tube morphogenesis: closure, but many openings remain

Nelson, W. James

doi:10.1016/j.tcb.2003.10.005

Cited by 33 publications

(26 citation statements)

References 16 publications

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“…At 7 h AEL, primary branches start to form by invaginating or budding in six different but stereotypical directions. At each bud site, two cells migrate out of the sac, followed by a small number [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] of cells. As they migrate, cells of the primary branch elongate and intercalate such that their initial side-by-side positioning is rearranged to an end-to-end configuration, with the lumen of resultant tubes enveloped by one single cell.…”

Section: Migration Cell Rearrangement and Change Of Cell Shapementioning

confidence: 99%

“…For this reason, the hormonal control of branching morphogenesis, which is clearly important but unique to the mammary gland [9][10][11], is not considered here. Nor do we discuss mechanisms controlling tubulogenesis as it is beyond the scope of this review, even though branching morphogenesis is one of several ways to generate and remodel epithelial tubes [12][13][14]. We will first discuss various modes of branching and their underlying cellular mechanisms in diverse branched organs.…”

Section: Introductionmentioning

confidence: 99%

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Comparative Mechanisms of Branching Morphogenesis in Diverse Systems

Sternlicht

Werb

2006

J Mammary Gland Biol Neoplasia

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Much progress has been made in recent years toward understanding mechanisms controlling branching morphogenesis, a fundamental aspect of development in a variety of invertebrate and vertebrate organs. To gain a deeper understanding of how branching morphogenesis occurs in the mammary gland, we compare and contrast the cellular and molecular events underlying this process in both invertebrate and vertebrate organs. Thus, in this review, we focus on the common themes that have emerged from such comparative analyses and discuss how they are implemented via a battery of signaling pathways to ensure proper branching morphogenesis in diverse systems.

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Section: Migration Cell Rearrangement and Change Of Cell Shapementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparative Mechanisms of Branching Morphogenesis in Diverse Systems

Sternlicht

Werb

2006

J Mammary Gland Biol Neoplasia

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“…Because tube morphogenic processes rely heavily on the spatial redistribution of existing components (15,16), an experimental approach that both measures and localizes elemental content is ideally suited to provide particular insight into this phenomenon. Synchrotron-derived x-rays from third-generation sources can now be focused such that both quantitation and spatial discrimination of metals can be achieved at the submicrometer scale by using x-ray fluorescence microprobe (XFM) analysis.…”

mentioning

confidence: 99%

X-ray fluorescence microscopy reveals large-scale relocalization and extracellular translocation of cellular copper during angiogenesis

Finney

Mandava

Ursos

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

179

142

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Although copper has been reported to influence numerous proteins known to be important for angiogenesis, the enhanced sensitivity of this developmental process to copper bioavailability has remained an enigma, because copper metalloproteins are prevalent and essential throughout all cells. Recent developments in x-ray optics at third-generation synchrotron sources have provided a resource for highly sensitive visualization and quantitation of metalloproteins in biological samples. Here, we report the application of x-ray fluorescence microscopy (XFM) to in vitro models of angiogenesis and neurogenesis, revealing a surprisingly dramatic spatial relocalization specific to capillary formation of 80 -90% of endogenous cellular copper stores from intracellular compartments to the tips of nascent endothelial cell filopodia and across the cell membrane. Although copper chelation had no effect on process formation, an almost complete ablation of network formation was observed. XFM of highly vascularized ductal carcinomas showed copper clustering in putative neoangiogenic areas. This use of XFM for the study of a dynamic developmental process not only sheds light on the copper requirement for endothelial tube formation but highlights the value of synchrotron-based facilities in biological research.copper chelation ͉ human microvascular endothelial cells ͉ infiltrating ductal breast carcinoma E ndogenous metals, such as Cu, Fe, and Zn, are subject to complex regulation in cellular systems. They are required as cofactors or regulators of numerous proteins (1) and yet, if present in overabundance, are toxic and expose the cellular environment to adventitious redox activity (2). This delicate balance is thought to be achieved by sequestration of these metals within their target proteins, metallochaperone systems, or distinct subcellular compartments (3). Although many proteins that handle transition metals within cells have been identified (4), our knowledge as to how metal content is dynamically regulated in eukaryotic cells is still limited. To what extent does regulation of the metal ion content of individual metalloproteins, mediated by protein-protein interactions, serve as an additional level of regulation of cellular metalloprotein activity? Could such regulation result in polarization of transition metal distribution throughout a cell during a biological process? To begin to explore such questions, we examined a cellular system whose biology is acutely sensitive to modulation by metals.

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“…For example, secondary neurulation in amniotes and NT formation in Xenopus and zebrafish involve an epithelialization process or MET. Molecular pathways regulating MET have been well described for several tissues (Dressler, 2002;Hogan and Kolodziej, 2002;Lubarsky and Krasnow, 2003;Nelson, 2003;Hay, 2005;Lee et al, 2006;Thiery and Sleeman, 2006;Baum et al, 2008) and some components of these pathways could also be implicated in neurulation. Moreover, epithelialization of the NT is also likely to involve genes expressed in the NT that are not known components of these pathways.…”

Section: How Conserved Are the Molecular Pathways Regulating Neurulatmentioning

confidence: 99%

“…Despite their common basic architecture, these biological tubes are shaped by a variety of morphogenetic mechanisms (Hogan and Kolodziej, 2002;Lubarsky and Krasnow, 2003;Nelson, 2003). The neural tube (NT), the precursor of the brain and spinal chord, is no exception.…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of neurulation: First impressions do not count

Harrington

Hong

Brewster

2009

Molecular Reproduction Devel

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SUMMARYThe central nervous system of vertebrate embryos originates from the neural tube (NT), a simple epithelium surrounding a central lumen. The mechanisms underlying the shaping of the NT, a process otherwise known as neurulation, have been the focus of numerous studies, using a variety of model systems. Yet, it remains unclear to what extent neurulation is conserved across vertebrates. This review provides a comparison between modes of neurulation, with a focus on cellular mechanisms. An emerging concept is that cell behaviors reveal similarities between modes of neurulation that cannot be predicted from morphological comparisons.Mol. Reprod. Dev. 76: 954-965, 2009. ß

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Tube morphogenesis: closure, but many openings remain

Abstract: Epithelial and endothelial tubes form the basic structure of many organs and tissues in the fruit fly Drosophila melanogaster, the nematode Caenorhabditis elegans, zebrafish and mammals.

Cited by 33 publications

References 16 publications

Comparative Mechanisms of Branching Morphogenesis in Diverse Systems

Comparative Mechanisms of Branching Morphogenesis in Diverse Systems

X-ray fluorescence microscopy reveals large-scale relocalization and extracellular translocation of cellular copper during angiogenesis

Comparative analysis of neurulation: First impressions do not count

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