Tubercular Uveitis: Nuggets from Collaborative Ocular Tuberculosis Study (COTS)-1

Clinics of ocular tuberculosis: A review

“…The anatomical distribution of TBU across various studies is summarized in Table 3, classified based on the standardized definitions above. To date, the multinational study by COTS is by far the largest and most diverse OTB population that has been analyzed 39 . A common limitation expressed by these studies is their retrospective nature, which can lead to imprecise and non‐standardized data collection.…”

“…Urzua and colleagues 57 observed a positive correlation between poorer baseline visual acuity (VA) and duration of symptoms at presentation. When considering patients within COTS, Testi and colleagues 39 suggested that the finding of patients receiving corticosteroids before initiation of ATT and being resultantly affected by distinctly high rates of treatment failure could indicate a delay in the diagnosis of OTB because specific therapy could not be initiated, resulting in a worse outcome. Poorer visual outcomes and complications have been associated with delayed diagnosis not only in OTB, 57‐59 but in other etiologies of ocular disease (Fuchs iridocyclitis, Vogt‐Koyanagi‐Harada associated uveitis, ocular syphilis, and so on) as well 57 …”

Ocular tuberculosis: Where are we today?

“…Results from COTS-1 showed that among 702 patient affected by OTB with documented radiological results, 26.9% had radiologic features suggestive of inactive TB on chest X-ray, and 68.6% had positive findings on chest computed tomography (CT). [ 66 ] CT appears to be more a sensitive technique, that can be a valuable diagnostic tool in patients with ocular findings suggestive of OTB and history of exposure with no signs of active infection.…”

Twenty-four Month Outcomes in the Collaborative Ocular Tuberculosis Study (COTS)-1: Defining the “Cure” in Ocular Tuberculosis

“…The COTS-1 was a retrospective study conducted at 25 international centers with participation of over 30 international uveitis experts. 1,2,5 All the participating centers have been listed in Appendix 1. The data was collected from patients diagnosed with OTB between January 2004 to December 2014.…”

“…The Collaborative Ocular Tuberculosis Study Group (COTS) has brought together a number of international uveitis experts from various centers globally so that the challenge posed by ocular tuberculosis (OTB) could be tackled. 1,2 The long-term goals in the management of OTB include preservation of visual function and minimizing the relapse of the disease. [2][3][4] The importance of anti-tubercular therapy (ATT) to improve patient outcomes and reduce the treatment failures has been underlined in the data generated by the COTS group.…”