Tuberculoma of Hypophysis With Insufficiency of Anterior Lobe

Kirshbaum, Jack D.

doi:10.1001/archinte.1941.00200120054004

“…In an 11-year pre-antibiotic-era autopsy series involving 14,160 specimens from Cook County Hospital, including 652 cases of pulmonary tuberculosis and 368 cases of tuberculous meningitis, only two specimens yielded evidence of anterior pituitary involvement (68). In the selected group of patients with late generalized tuberculosis, Slavin et al noted a 4% incidence of pituitary involvement (42).…”

Section: Pituitary Gland Tuberculosismentioning

confidence: 99%

“…It has been postulated that pituitary tuberculosis can arise from hematogenous seeding, either in the presence or absence of miliary disease, or from direct extension from the sphenoid sinus, brain, or meninges (68). Depending on the pathogenesis, infection can involve the pituitary gland alone or be associated with tuberculosis in an adjacent or distant site.…”

Section: Pituitary Gland Tuberculosismentioning

confidence: 99%

“…Patients may be relatively asymptomatic, and the endocrine abnormalities may be subtle and noted only on detailed investigation. Any portion of the pituitary (including anterior, posterior, and the stalk) or the hypothalamus can be involved; consequently, presentations can vary and include growth retardation, hypogonadism, galactorrhea-amenorrhea related to excess prolactin secretion, diabetes insipidus, and even panhypopituitarism (68, 70–74). Because of the small numbers of cases reported and the incomplete documentation of many of the reported cases, there is not a pathognomonic presentation associated with pituitary gland tuberculosis.…”

Section: Pituitary Gland Tuberculosismentioning

confidence: 99%

See 1 more Smart Citation

Endocrine and Metabolic Aspects of Tuberculosis

Vinnard

¹

,

Blumberg

²

2017

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Endocrine and metabolic derangements are infrequent in patients with tuberculosis, but they are important when they occur. The basis for these abnormalities is complex. While Mycobacterium tuberculosis has been described to infect virtually every endocrine gland, the incidence of gland involvement is low, especially in the era of effective antituberculosis therapy. Furthermore, endocrine and metabolic abnormalities do not always reflect direct infection of the gland but may result from physiological response or as a consequence of therapy. Metabolic disease may also predispose patients to the development of active tuberculosis, particularly in the case of diabetes mellitus. While hormonal therapy may be necessary in some instances, frequently these endocrine complications do not require specific interventions other than antituberculous therapy itself. With the exception of diabetes mellitus, which will be covered elsewhere, this chapter reviews the endocrinologic and metabolic issues related to tuberculosis.

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“…Patients may be relatively asymptomatic, and the endocrine abnormalities may be subtle and noted only on detailed investigation. Any portion of the pituitary (including anterior, posterior, and the stalk) or the hypothalamus can be involved; consequently, presentations can vary and include growth retardation, hypogonadism, galactorrhea-amenorrhea related to excess prolactin secretion, diabetes insipidus, and even panhypopituitarism (68,(70)(71)(72)(73)(74).…”

Section: Pituitary Gland Tuberculosismentioning

confidence: 99%

Endocrine and Metabolic Aspects of Tuberculosis

Vinnard

¹

,

Blumberg

²

2021

Tuberculosis and Nontuberculous Mycobacterial Infections

0

View full text Add to dashboard Cite

Endocrine and metabolic derangements are infrequent in patients with tuberculosis, but they are important when they occur. The basis for these abnormalities is complex. While Mycobacterium tuberculosis has been described to infect virtually every endocrine gland, the incidence of gland involvement is low, especially in the era of effective antituberculosis therapy. Furthermore, endocrine and metabolic abnormalities do not always reflect direct infection of the gland but may result from physiological response or as a consequence of therapy. Metabolic disease may also predispose patients to the development of active tuberculosis, particularly in the case of diabetes mellitus. While hormonal therapy may be necessary in some instances, frequently these endocrine complications do not require specific interventions other than antituberculous therapy itself. With the exception of diabetes mellitus, which will be covered elsewhere, this chapter reviews the endocrinologic and metabolic issues related to tuberculosis.

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“…In addition, a few rats of the albino and dark grey-brown strains with diethylstilboestrolmethyl-ether pellets showed either black pigmentation of the capsule around the pellet or similar changes in the male mammary gland. Kirshbaum & Pfeiffer [1941] showed that local application of testosterone propionate induced deposition of melanin in the bill of the sparrow.…”

mentioning

confidence: 99%

The Influence of Testosterone Propionate on Pigmentation of the Mammary Nipples in Female Mice

Flaks¹

1946

Journal of Endocrinology

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In recent experiments on the influence of testosterone propionate on tumours induced by carcinogens, a striking pigmentation of the mammary nipples in female mice of several strains was observed. The nipples were easily visible against the brighter background of the abdominal coat, while they were hardly noticeable in the untreated mice of the same strains. In previous experiments [Flaks & Ber, 1938, 1939a, in which albino mice were treated with very large doses of testosterone propionate, these changes were not noticed, although the mice were maintained for a period of nearly 12 months.It is known from earlier work that injections of oestrogens in guinea-pigs and humans induced hyperpigmentation of the nipples [Lipschutz ]. Local application of oestrone and stilboestrol was also shown to cause hyperpigmentation of the nipples in male guinea-pigs [Fierz, 1939].The influence of androgens on pigmentation was reported by Hamilton & Hubert [1938]: the skin in castrated men, which is generally pale, became darker after treat¬ ment with androgenic hormones. Edwards, Hamilton, Duntley & Hubert [1941] found that the melanin content of the skin in eunuchs is subnormal. Treatment with androgens resulted in an increase of the pigment. Forbes [1942] described hair cha ages and pigmentation of the mammary nipples in rats with implanted pellets of sex hormones. In these experiments a number of oestrogens and androgens were employed. All the oestrogens, but only androsterone among the androgens, caused a partial pigmentation of the fur of albino rats and alopecia in dark grey-brown rats.Testosterone propionate and dipropionate, and androsterone, did not induce pigmenta¬ tion of the nipples. In addition, a few rats of the albino and dark grey-brown strains with diethylstilboestrolmethyl-ether pellets showed either black pigmentation of the capsule around the pellet or similar changes in the male mammary gland. Kirshbaum & Pfeiffer [1941] showed that local application of testosterone propionate induced deposition of melanin in the bill of the sparrow. MATERIAL AND METHODSOne hundred and eighty mice of four strains were employed in the experiments: CBA-black agouti, C3H-dark grey-brown, Strong -albino and mixed stock (black, brown and albino). All mice were virgins, about 3 months old, except two breeding C3H mice which were approximately 12 and 17 months old. Seventy mice were injected, under the skin of the abdomen, with a 2-5% solution of testosterone propionate in arachis oil. Each mouse received weekly injections of 6-25 mg. of * Bertram Parkinson Research Fellow.

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Tuberculoma of Hypophysis With Insufficiency of Anterior Lobe

Cited by 16 publications

References 10 publications

Endocrine and Metabolic Aspects of Tuberculosis

Endocrine and Metabolic Aspects of Tuberculosis

Endocrine and Metabolic Aspects of Tuberculosis

The Influence of Testosterone Propionate on Pigmentation of the Mammary Nipples in Female Mice

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