Tuberculosis After Renal Transplantation

Kâaroud, H.; Béji, S.; Boubaker, Karima; Abderrahim, E.; Hamida, F. Ben; Abdallah, T. Ben; Younsi, F. El; Moussa, F. Ben; Kheder, A.

doi:10.1016/j.transproceed.2007.02.032

Cited by 23 publications

(27 citation statements)

References 6 publications

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“…9 A previous history of infection, long duration of dialysis before transplant, and poor socioeconomic conditions are also considered as risk factors. 10 In our case, we did not identify any of the risk factors reported in the literature.…”

Section: Discussioncontrasting

confidence: 65%

Untitled

Barbouch

Hajji²,

Helal³

et al. 2017

Exp Clin Transplant

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Tuberculosis is one of the leading infections after renal transplant, particularly in developing countries where the incidence and prevalence in the general population are high. Diagnosis requires bacteriologic and histologic confirmation. Interactions among the antitubercular drugs and the immunosuppressive agents have to be considered while prescribing, and surveillance for adverse effects is required. Although rare, case reports are available on extrapulmonary tuberculosis in allograft recipients. Here, we present a 25-year-old kidney transplant recipient who was diagnosed with lymph node tuberculosis under uncommon circumstances but who had a good outcome. This case report illustrates the difficulties in diagnosis of tuberculosis, changes in therapeutic protocols, and prognostic factors and highlights the effects of infectious complications with immunosuppressive therapy in this particular patient population.

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Section: Discussioncontrasting

confidence: 65%

Untitled

Barbouch

Hajji²,

Helal³

et al. 2017

Exp Clin Transplant

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“…Extra pulmonary presentations of TB are more frequent in kidney transplant recipients compared to immunocompetent patients, observed in 18,7% of cases in our study versus 28.6 to 50% in other studies [4,32,33]. Extra pulmonary symptoms are sometimes atypical such as an unusual gastrointestinal symptomatology, skin lesions not improved by antibiotics, and/or dissemination [2,16,31].…”

Section: Discussionmentioning

confidence: 54%

“…Recurrence of TB is a frequent complication among kidney transplant recipients [33]. More than 9 months of treatment may be necessary to prevent recurrence [21,42,53,[56][57][58].…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium Tuberculosis Infection Following Kidney Transplantation

Boubaker¹,

Abderrahim²,

Abdallah³

et al. 2013

AJIDM

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Introduction and Aims. Post-transplant tuberculosis (TB) is a problem in successful long-term outcome of renal transplantation recipients. Our objective was to describe the pattern and risk factors of TB infection and the prognosis in our transplant recipients. Patients and Methods. This study was a retrospective review of the records of 491 renal transplant recipients in our hospital during the period from January 1986 to December 2009. The demographic data, transplant characteristics, clinical manifestations, diagnostic criteria, treatment protocol, and long-term outcome of this cohort of patients were analyzed. Results. 16 patients (3,2%) developed post-transplant TB with a mean age of 32,5 ± 12,7 (range: 13-60) years and a mean post-transplant period of 36,6months (range: 12,3 months-15,9 years). The forms of the diseases were pulmonary in 10/16 (62,6%), disseminated in 3/16 (18,7%), and extrapulmonary in 3/16 (18,7%). Graft dysfunction was observed in 7 cases (43,7%) with tissue-proof acute rejection in 3 cases and loss of the graft in 4 cases. Hepatotoxicity developed in 3 patients (18,7%) during treatment. Recurrences were observed in 4 cases after early stop of treatment. Two patients (12.5%) died. Conclusion. Extra pulmonary and disseminated tuberculosis were observed in third of our patients. More than 9months of treatment may be necessary to prevent recurrence.

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“…Extrapulmonary presentations of TB are more frequent in kidney transplant recipients compared to immunocompetent patients, observed in 18,7% of cases in our study versus 28.6 to 50% in other studies [4,32,33]. Extra pulmonary symptoms are sometimes atypical such as an unusual gastro-intestinal symptomatology, skin lesions not improved by antibiotics and/or dissemination [16,31,34].…”

Section: Disscussionmentioning

confidence: 54%

“…Recurrence of TB is a frequent complication among kidney transplant recipients [33]. More than 9 months of treatment may be necessary to prevent recurrence [21,42,53,56,57,58].…”

Section: Disscussionmentioning

confidence: 99%

Mycobacterium Tuberculosis Infection Following Kidney Transplantation

Boubaker¹,

Abderrahim²,

Abdallah³

et al. 2013

AJMSM

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Tuberculosis (TB) is one of the major causes of morbidity and mortality worldwide. Post-transplant TB is a problem in successful long-term outcome of renal transplantation recipients. It is a life-threatening opportunistic infection that is frequently encountered, but the diagnosis is often delayed. With the emergence of newer potent immunosuppressive regimens and an increased incidence of TB in the general population, post-transplant TB among transplant recipients can be anticipated. Our objective was to describe the pattern and risk factors of TB infection, and the prognosis in our transplant recipients. This study was a retrospective review of the records of 491 renal transplant recipients in our hospital during the period from January 1986 to December 2009. The demographic data, transplant characteristics, clinical manifestations, diagnostic criteria, treatment protocol, and long-term outcome of this cohort of patients were analyzed. 16 patients (3.2%) developed posttransplant TB with a mean age of 32.5 ± 12.7 (range: 13-60) years and a mean post-transplant period of 36,6 months (range: 12,3 months -15.9 years). The forms of the diseases were pulmonary in 10 /16 (62.6%), disseminated in 3/16 (18.7%) and extrapulmonary in 3/16 (18.7%). All patients initially received 4-drug combination therapy. Because of drug interaction, an increase in the dose of calcineurium inhibitor and steroid was done in 2 cases and in steroids alones in 1 case. Graft dysfunction was observed in 7 cases (43,7%) with tissue-proof acute rejection in 3 cases and loss of the graft in 4 cases. Hepatotoxicity developed in 3 patients (18.7%) during treatment. Reccurence were observed in 4 cases after early stop of treatment. Two patients (12.5%) died. Extrapulmonary and disseminated tuberculosis were observed in third of our patients. More than 9 months of treatment may be necessary to prevent recurrence.

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Tuberculosis After Renal Transplantation

Cited by 23 publications

References 6 publications

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Mycobacterium Tuberculosis Infection Following Kidney Transplantation

Mycobacterium Tuberculosis Infection Following Kidney Transplantation

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