Tuberculosis and comorbidities in urban areas in Argentina. A gender and age perspective

Echazarreta, Alberto; Zerbini, Elsa V.; Sandro, José De; Sáenz, César; Yessi, Leyla; Saad, Romina; Manonelles, G.; Cuello, Mónica

doi:10.7705/biomedica.v38i0.3904

Cited by 15 publications

(12 citation statements)

References 18 publications

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“…The risk of tuberculosis is higher in patients aged below 50 and above 70 [8]. Previously, the incidence of tuberculosis has been reported to be higher in patients aged 20-24 years [9]. In our study, the patients' ages were very variable in both groups but the patients with hemoptysis were younger than those without hemoptysis.…”

Section: Discussioncontrasting

confidence: 37%

Hemoptysis in Tuberculosis: What should we pay attention to?

Keskin¹,

Dirol²,

Ergin³

2021

Pamukkale Medical Journal

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Increased complication risk of surgical interventions performed in patients with hemoptysis is a common concern among surgeons. Therefore, here, we investigated the surgical outcomes of tuberculosis patients with hemoptysis. Materials and methods: Patients, between 1985 and 2018, diagnosed with tuberculosis surgically, were analyzed retrospectively. The patients were divided into two groups; those without hemoptysis (Group 1) and those with hemoptysis (Group 2). The analysis included age, gender, symptoms, comorbidities, Positron Emission Tomography-Computed Tomography (PET-CT) findings, surgical interventions, perioperative complications, lengths of hospital stay, recurrence of hemoptysis, and comparison of Group 1 and 2. Results: 541 patients with pulmonary tuberculosis diagnosed surgically were analyzed. 448 patients were in Group 1 and 93 patients were in Group 2. The patients in Group 2 were significantly younger than the patients in Group 1 (Group 1 mean age 57.8±6.2, Group 2 mean age 31.2±5.3, p<0.01). The most frequent comorbidity was malignancy in both groups. Cavitation was more common in Group 2 (Group 1 92 (20.5%), Group 2 79 (84.9%), p<0.01). Postoperative complications and hospital stay length were similar in both groups and there was no hemoptysis recurrence in Group 2. There was no perioperative death in Group 1 while 3 (3%) patients died in Group 2. Conclusion:The surgical morbidity and mortality of patients diagnosed with tuberculosis after the surgical intervention performed for the diagnosis or treatment of the hemoptysis were not significantly different from those of the patients without hemoptysis

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Section: Discussioncontrasting

confidence: 37%

Hemoptysis in Tuberculosis: What should we pay attention to?

Keskin¹,

Dirol²,

Ergin³

2021

Pamukkale Medical Journal

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“…The study aimed to describe the temporal trend of tuberculosis cases according to gender and age group and to make predictions considering the current context in an endemic municipality of northeast Brazil. The study also showed a curious fact, that is, although tuberculosis most commonly affects men of the economically active and older adult age groups, there was a high incidence of the disease in women in the 15 to 59 years age group, an unusual phenomenon, compared with other studies carried out in Brazil and internationally [15][16][17][18][19][20].…”

Section: Discussionmentioning

confidence: 64%

Tuberculosis forecasting and temporal trends by gender and age in a high endemic city of Northeast Brazil: Are we achieving the disease elimination stage?

Andrade

Arroyo

Ramos

et al. 2021

Preprint

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Objective: to describe the temporal trend of tuberculosis cases according to gender and age group and to make forecasts in an endemic municipality of northeast Brazil. Method: This was a Time Series study, carried out in a municipality in the northeast of Brazil. Population was composed of tuberculosis cases among residents of the municipality, reported between the years 2002 and 2018. An exploratory analysis of the monthly rates of tuberculosis detection, smoothed according to gender and age group, was performed. Subsequently, the progression of the trend and predictions of the disease were also characterized according to these aspects. For the trends forecast, the seasonal autoregressive linear integrated moving average – Seasonal ARIMA model and the usual Box-Jenkins method were used to choose the most appropriate models.Results: A total of 1,620 cases of tuberculosis were reported, with an incidence of 49.7 cases per 100,000 inhabitants in men and 34.0 per 100,000 in women. Regarding the incidence for both genders, there was a decreasing trend, which was similar for age. Evidence resulting from the application of the time series shows a decreasing trend between the years 2002–2018, however, it is unlikely that there will be a significant fall in the disease before 2022.

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“…The previous studies found that some characteristic factors were not related to the hepatotoxic effect. The age, gender alcohol intake, and body mass index (BMI) did not have any relationship with hepatotoxic effects [ 17 , 18 ]. Another study explained that women might be at risk for TB because a patriarchal culture is common in Indonesian society; therefore, men have better health than women.…”

Section: Discussionmentioning

confidence: 99%

“…It will aggravate the infectious disease, making nutritional status the major cause of treatment failure in TB patients. Furthermore, malnutrition and TB are two interconnected problems in which malnutrition can impact immune system deterioration and make the affected people's immune systems more susceptible to TB infection than healthy people's immune systems [ 18 , 23 ]. TB is often interconnected with poverty, malnutrition, hygiene, overcrowding, and lack of knowledge [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…Another study explained that women might be at risk for TB because a patriarchal culture is common in Indonesian society; therefore, men have better health than women. Based on the facts in developing countries, most low-income families are exposed to smoke from firewood or biogas, Exclusion criteria (n=71) Died (2), developed advanced stage (2), no longer taking medicine (6), drop out (13), disease complication (35), missed (2), not willing to be respondent ( 11) which is burned as fuel, causing an increase in the incidence of TB in poor women in developing countries [18]. Furthermore, because many poor women live in homes with poor lighting and ventilation, the risk of being infected with TB bacteria is higher [18].…”

Section: Discussionmentioning

confidence: 99%

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Investigating the Relationship between Knowledge and Hepatotoxic Effects with Medication Adherence of TB Patients in Banyumas Regency, Indonesia

Perwitasari

Setiawan

Nguyễn

et al. 2022

International Journal of Clinical Practice

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Tuberculosis (TB) still remains the burden in Indonesia. One of the factors that may influence the treatment success of TB is patient’s adherence. However, the hepatotoxicity of the TB medicine may decrease the patient’s adherence. Our study’s aim is to investigate the relationship between the patient's knowledge and the hepatotoxicity with medication adherence of TB patients in Banyumas Regency. This study was conducted at one Community Lung Health Center and two hospitals in Banyumas Regency, Purwokerto, Center of Java, Indonesia. The respondents were 91 TB patients with hepatotoxicity characterized by an increased aspartate transaminase (AST) and alanine aminotransferase (ALT). The level of the patients’ knowledge about the hepatotoxicity effect was determined using a questionnaire. The patients’ adherence was determined using the Medication Adherence Rating Scale -5 (MARS) questionnaire and pill count methods. Most of the patients were male (53.8%), the age was in the range of 18–29 years old (3.5%), they have no smoking history (59.3%), and their last education majorly was senior high school (46.2%). Most TB patients had poor knowledge (47.3%) and the hepatotoxic effect often appeared in grade 1 (61.5%). The TB patients with a good and moderate level of knowledge were 17.6% and 35.2%, respectively. The TB patients with moderate and severe hepatotoxicity were 39.4% and 1.1%, respectively. The measurement of the level of respondents’ adherence using MARS-5 showed that 51.6% of patients had good adherence. We determined the rest of the drug-using pill count method, which resulted in 62.6% of patients adhering to taking antituberculosis drugs. TB patients with a sufficient knowledge and those with mild hepatotoxicity show the higher adherence ( p < 0.001 ). There is a significant relationship between a high level of the patient’s knowledge about hepatotoxicity effect, less severity of the hepatotoxic effect, and increased patient adherence in taking the medication.

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Tuberculosis and comorbidities in urban areas in Argentina. A gender and age perspective

Abstract: This study will help recognize tuberculosis patients' characteristics and comorbidities influencing the development and evolution of the disease from an age and gender perspective to enable the development of social and community-based strategies.

Cited by 15 publications

References 18 publications

Hemoptysis in Tuberculosis: What should we pay attention to?

Hemoptysis in Tuberculosis: What should we pay attention to?

Tuberculosis forecasting and temporal trends by gender and age in a high endemic city of Northeast Brazil: Are we achieving the disease elimination stage?

Investigating the Relationship between Knowledge and Hepatotoxic Effects with Medication Adherence of TB Patients in Banyumas Regency, Indonesia

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