Tuberculosis and the blood — A special relationship?

Cameron, S. J.

doi:10.1016/0041-3879(74)90067-1

Cited by 64 publications

(27 citation statements)

References 61 publications

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“…One of these was Pelger-Huet nuclear anomaly [8], and the other was the abnormal peroxi dase-positive primary granules characteristic of Chediak-Steinbrink-Higashi syndrome [9], The former morphological abnormality is usually seen in myelo proliferative and preleukaemic disorders [11,12], Ca meron [3] has reported a case of tuberculosis pre senting as myelomonocytic leukaemia which showed a favourable response to antituberculous chemother apy. Albeit various mechanisms have been postulated to explain the blood dyscrasias in tuberculosis [3,13], the current view favours the immunological alteration of the body by disseminated tuberculosis [3,13]. How ever, this mechanism fails to explain all the haematological abnormalities in this disease.…”

Section: Discussionmentioning

confidence: 99%

“…Serious blood dyscrasias are commonly seen in non-reactive disseminated tuberculosis [3][4][5][6][7] as well as in atypical mycobacterial infections. Few abnor mal morphological features in tuberculosis have been reported [8,9].…”

Section: Discussionmentioning

confidence: 99%

“…Protean haematological abnormalities have been doc umented in disseminated tuberculosis of the nonreactive type [3][4][5][6][7]. This paper, which describes an atypical mycobacterial infection in a patient who presented with florid haematological defects, empha sizes the rarity of the association of such abnormal fea tures of the blood with tuberculous infection.…”

Section: Introductionmentioning

confidence: 99%

“…Tuberculosis may coincidentally occur in some pa tients with blood abnormalities, or it may develop as an opportunistic infection in the immunocompro mised host, particularly in patients with primary blood disorders, including blood dyscrasias [1][2][3]. Protean haematological abnormalities have been doc umented in disseminated tuberculosis of the nonreactive type [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Promyelocytic Leukaemoid Reaction: An Atypical Presentation of Mycobacterial Infection

Ahmed¹

1991

Acta Haematol

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A young woman presented with mild pyrexia and antepartal haemorrhage due to disseminated intravascular coagulation. She had pancytopenia in the peripheral blood and granulocytic maturation arrest at the promyelocyte stage in the bone marrow. Her urine and bone marrow grew Mycobacterium kansasii on culture. Antituberculous treatment eliminated the infection and restored the normality of bone marrow and peripheral blood.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Promyelocytic Leukaemoid Reaction: An Atypical Presentation of Mycobacterial Infection

Ahmed¹

1991

Acta Haematol

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“…While most patients with TB do not manifest major hematologic abnormalities, some patients with late generalized or chronic hematogenous TB and most with nonreactive TB have serious hematologic abnormalities, including leukopenia, thrombocytopenia, anemia, leukemoid reactions, myelofibrosis, and polycythemia (Cameron 1974). Leukemoid reactions may suggest acute leukemia, although most patients in whom hematogenous TB coexists with the clinical picture ofleukemia have both diseases.…”

Section: Hematologic Findings In Tuberculosismentioning

confidence: 99%

Hematologic Findings in Mycobacterial Infections Among Immunosuppressed and Immunocompetent Patients

Akpek

2004

Tuberculosis

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Severe thrombocytopenia following intralesional BCG therapy

Norton¹,

Shulman²,

Corash³

et al. 1978

Cancer

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Of eight patients we have seen with disseminated BCG infection (BCGosis) following BCG injection into primary melanomas, all eight have developed a significant decrease in platelet count of 33 to 99% mean * 1 SE = 63 f 9%) from the preinjection values. A concomitant randomized control group with melanoma not receiving BCG did not show a significant platelet depression. Two patients receiving BCG developed a profound thrombocytopenia (platelet count less than 2,000) that persisted for two weeks. These patients had both received approximately 5 X lo8 viable BCG organisms intralesionally and required isoniazid therapy for the BCGosis that developed. BCGosis was documented by the presence of granulomas in liver and/or bone marrow of both patients, and the growth of BCG from bone marrow and liver biopsies in one patient. Both severely affected patients had short platelet survival but evidence of normal platelet production in that megakaryocytes were plentiful in the bone marrow. Using sera from before, during and after the severe thrombocytopenic episode in both patients with and without added BCG, immunologic evidence for a n antiplatelet antibody could not be substantiated by complement fixation and serotonin release studies. After ethambutol, rifampin and prednisolone therapy was instituted in both patients, fevers due to BCGosis disappeared within a day, but platelet counts did not begin to rise for 11 and 14 days, respectively. Severe thrombocytopenia can occur following BCG administration and should be recognized as a potential life-threatening complication in all patients receiving intralesional BCG therapy.Cancer 41:820-826, 1978. ACILLUS CALMETTE GUERIN (BCG), AN ATYP-B ical variant of the tubercle bacillus, is a widely used agent for the immunotherapy of human malignancy. Complications of BCG immunotherapy occur however including malaise, fever, rash, abscesses, ulcers, adenopathy and hepatic dysfunction. '' Complications have been more frequently associated with the intralesional administration of BCG," and in 1973 Sparks reported a 24% incidence of disseminated BCG infection (BCGosis) following intralesional injection. la Deaths have been seen following multiple BCG inoculations in the same patient and have been felt to be caused by a hypersensitivity reaction. lo However, in general

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Tuberculosis and the blood — A special relationship?

Cited by 64 publications

References 61 publications

Promyelocytic Leukaemoid Reaction: An Atypical Presentation of Mycobacterial Infection

Promyelocytic Leukaemoid Reaction: An Atypical Presentation of Mycobacterial Infection

Hematologic Findings in Mycobacterial Infections Among Immunosuppressed and Immunocompetent Patients

Severe thrombocytopenia following intralesional BCG therapy

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