Tuberculosis associated chronic obstructive pulmonary disease

Sarkar, Malay; Srinivasa,; Madabhavi, Irappa; Kumar, Kushal

doi:10.1111/crj.12621

Cited by 65 publications

(54 citation statements)

References 83 publications

(95 reference statements)

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“…The extent of bronchiectasis correlated strongly with the extent of decreased attenuation, again supporting the likelihood of small airways disease preceding bronchiectasis . TB has been reported as an important etiology for the development of BO in endemic regions in HIV‐negative patients . Although there was no association between prior TB and mosaic attenuation alone, the strong association with the combination of mosaic attenuation and bronchiectasis suggests that TB may lead to severe chronic lung disease.…”

Section: Discussionmentioning

confidence: 63%

“…6,17 TB has been reported as an important etiology for the development of BO in endemic regions in HIV-negative patients. [18][19][20] Although there was no association between prior TB and mosaic attenuation alone, the strong association with the combination of mosaic attenuation and bronchiectasis suggests that TB may lead to severe chronic lung disease. There was also a strong association between prior severe pneumonia and mosaic attenuation, as well as the combination of mosaic attenuation and bronchiectasis.…”

Section: Discussionmentioning

confidence: 99%

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High‐resolution computed tomography features of lung disease in perinatally HIV‐infected adolescents on combined antiretroviral therapy

Plessis

Andronikou

Machemedze³

et al. 2019

Pediatric Pulmonology

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Introduction Chronic lung disease is common in perinatally HIV‐infected children as they increasingly surviving into adolescence. There are few data on the radiologic spectrum of disease in this population. Methods Contrasted high‐resolution computed tomography (HRCT) was performed in ambulatory South African adolescents enrolled in a prospective study of perinatally‐infected adolescents aged 9 to 14 years established on combined antiretroviral therapy (cART) and followed for 36 months. Consecutive participants with reduced lung function (defined by a forced expiratory volume in 1 second [FEV1] of <80% normal and/or lung diffusion capacity [DLCO] <80% normal] underwent HRCT. History, clinical, and laboratory data were collected. Two radiologists blinded to clinical data and to each other, reported scans using standardized methodology; a third radiologist resolved discrepancies. Results Amongst 100 participants undergoing HRCT, median age was 13.8 years (12.8‐15.1). The median duration on cART was 8.4 years (IQR = 5.7‐9.8). Mosaic attenuation was the most common finding (73%). Of these 71 (91%) demonstrated associated air trapping radiologically consistent with bronchiolitis obliterans. Bronchiectasis occurred in 39% with significant correlation between extent of bronchiectasis and mosaic attenuation (r = 0.57, P < .001). Prior hospitaliszation for childhood pneumonia at any time before enrollment was associated with mosaic attenuation (OR = 3.9, 95%CI, [1.2‐12.5]); prior pulmonary tuberculosis (TB) was associated with the combination of mosaic attenuation and bronchiectasis (OR = 4.9, 95%CI, [1.6‐15.7]). Most participants (86%) with mosaic attenuation had stage III or IV HIV disease at time of HIV diagnosis (OR = 3.6; [0.9‐14.9]). Inter observer agreement between the two readers was good for bronchiectasis (K = 0.71) and moderate for mosaic attenuation (K = 0.51). Discussion Despite well‐controlled HIV and long duration of cART, HRCT changes were common in perinatally HIV‐infected adolescents. There was a high prevalence of small airways disease with and without associated bronchiectasis. These changes were associated with prior pulmonary TB or prior severe pneumonia. Strategies to prevent and treat early life respiratory infection must be strengthened to reduce the burden of chronic lung disease in HIV‐infected adolescents.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

High‐resolution computed tomography features of lung disease in perinatally HIV‐infected adolescents on combined antiretroviral therapy

Plessis

Andronikou

Machemedze³

et al. 2019

Pediatric Pulmonology

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“…The prevalence and impact of airflow limitation and/or COPD has been extensively studied and reviewed in asthma and obstructive sleep disorders 14,57,58 , bronchiectasis 59,60 , lung cancer 14,61 , interstitial lung diseases and pulmonary hypertension 62,63 , tuberculosis 64 , and human immunodeficiency virus (HIV) 65 , and will not be addressed in this review.…”

Section: Chronic Respiratory Diseasesmentioning

confidence: 99%

Chronic Respiratory Abnormalities in the Multi-Morbid Frail Elderly

Beghè¹,

Clini²,

Fabbri³

2017

BRN

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Two-thirds of people aged ≥65 years have multi-morbidity. Multi-morbidity includes both physical and mental health conditions, as anxiety and depression, that almost invariably affect patients with multiple symptomatic chronic diseases. Management of a patient with any of the chronic diseases that are part of multi-morbidity is not just the management of that single index disease, but must include the active search and proper treatment of concomitant chronic diseases. The presence of concomitant chronic diseases should not alter the management of the index disease (e.g., chronic obstructive pulmonary disease [COPD]), and concomitant chronic diseases should be treated according to single diseases guidelines regardless of the presence of the index disease, obviously with careful consideration that this choice implies complex management, polypharmacy and potential adverse effects. Preliminary management programs suggest that a holistic integrated approach might improve quality of life and reduce hospital admissions and death in these multimorbid patients. (BRN Rev. 2017;3:247-66)

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“…Greater lung injury, related to disability and impaired quality of life, has been associated with delayed diagnosis of tuberculosis, quantity of previous treatments, smoking, malnutrition, and a high bacillary load at the initiation of antituberculosis therapy. (6)(7)(8)(9)(10) The functional changes resulting from PTB that are observed after treatment manifest as restrictive lung disease (RLD), obstructive lung disease (OLD), or mixed obstructive-restrictive lung disease (MORLD), regardless of the history of exposure to smoking. (11) The most commonly described functional change is OLD.…”

Section: Introductionmentioning

confidence: 99%

“…(11) The most commonly described functional change is OLD. (6,7,12) The prevalence of OLD after treatment for PTB is estimated to range from 15% to 77%, (10,12) whereas that of MORLD, the second most prevalent, is estimated to range from 9% to 34%. (9,12) At one center in Brazil, MORLD was reported to be the most common functional change, with a prevalence of 34%.…”

Section: Introductionmentioning

confidence: 99%

Spirometry results after treatment for pulmonary tuberculosis: comparison between patients with and without previous lung disease: a multicenter study

Mancuzo¹,

Netto²,

Sulmonett³

et al. 2020

J Bras Pneumol.

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Objective: To compare patients with and without previous lung disease, in terms of the spirometry results after they had been treated for pulmonary tuberculosis (PTB) and cured, as well as to analyze risk factors related to functional severity. Methods: This was a cross-sectional, multicenter study conducted at four referral centers in Brazil. Patients were divided into two groups: those with a history of lung disease or smoking (LDS+ group); and those with no such history (LDS− group). Patients underwent spirometry (at least six months after being cured). Sociodemographic and clinical data were collected. Results:A total of 378 patients were included: 174 (46.1%) in the LDS+ group and 204 (53.9%) in the LDS− group. In the sample as a whole, 238 patients (62.7%) had spirometric changes. In the LDS+ group, there was a predominance of obstructive lung disease (in 33.3%), whereas restrictive lung disease predominated in the LDS− group (in 24.7%). Radiological changes were less common in the LDS− group than in the LDS+ group (p < 0.01), as were functional changes (p < 0.05). However, of the 140 (79.1%) LDS− group patients with a normal or minimally altered chest X-ray, 76 (54%) had functional changes (p < 0.01). The risk factors associated with functional severity in the LDS− group were degree of dyspnea (p = 0.03) and moderate or severe radiological changes (p = 0.01). Conclusions: Impaired pulmonary function is common after treatment for PTB, regardless of the history of lung disease or smoking. Spirometry should be suggested for patients who develop moderate/severe dyspnea or relevant radiological changes after treatment for PTB.

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Tuberculosis associated chronic obstructive pulmonary disease

Abstract: Objectives: Reviewed the epidemiology, clinical characteristics, mechanisms, and treatment of tuberculosis associated chronic obstructive pulmonary disease.

Cited by 65 publications

References 83 publications

High‐resolution computed tomography features of lung disease in perinatally HIV‐infected adolescents on combined antiretroviral therapy

High‐resolution computed tomography features of lung disease in perinatally HIV‐infected adolescents on combined antiretroviral therapy

Chronic Respiratory Abnormalities in the Multi-Morbid Frail Elderly

Spirometry results after treatment for pulmonary tuberculosis: comparison between patients with and without previous lung disease: a multicenter study

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