Tuberculosis, BCG Vaccination, and COVID-19: Are They Connected?

Borges, Kellen Christina Malheiros; Costa, Adeliane Castro da; Barbosa, Lília Cristina de Souza; Ribeiro, Kaio Mota; Anjos, Laura Raniere Borges dos; Kipnis, André; Junqueira-Kipnis, Ana Paula

doi:10.2174/1389557522666220104152634

Cited by 6 publications

(3 citation statements)

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“…Besides from the novel COVID vaccination, the bacillus Calmette−Guérin (BCG) vaccine against tuberculosis holds general protection from wide range of infectious diseases [101,102]. In the era of COVID, the BCG vaccine has been proposed against SARS-CoV-2 severity where BCG vaccination is shown to have negatively associated with COVID-19 mortality [103,104]. One study showed that BCG vaccine against COVID-19 was significant in young population, but was not as effective in older population [105].…”

Section: Vaccinationmentioning

confidence: 99%

Long COVID and its Management

Koc¹,

Xiao²,

Liu³

et al. 2022

Int. J. Biol. Sci.

165

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The pandemic of COVID-19 is the biggest public health crisis in 21 st Century. Besides the acute symptoms after infection, patients and society are also being challenged by the long-term health complications associated with COVID-19, commonly known as long COVID. While health professionals work hard to find proper treatments, large amount of knowledge has been accumulated in recent years. In order to deal with long COVID efficiently, it is important for people to keep up with current progresses and take proactive actions on long COVID. For this purpose, this review will first introduce the general background of long COVID, and then discuss its risk factors, diagnostic indicators and management strategies. This review will serve as a useful resource for people to understand and prepare for long COVID that will be with us in the foreseeable future.

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Section: Vaccinationmentioning

confidence: 99%

Long COVID and its Management

Koc¹,

Xiao²,

Liu³

et al. 2022

Int. J. Biol. Sci.

165

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“…Borges et al[ 20 ] mentioned that BCG vaccine strains help excite basal defenses and may be used as an accessional defense in future pandemics. [ 21 ]…”

Section: Discussionmentioning

confidence: 99%

Pandemic of the century: COVID-19 in inflammatory rheumatic diseases of a national cohort with 3,532 patients

Yurdakul,

Bodur,

Kıvanç Cengiz

et al. 2024

Arch Rheumatol

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Objectives: This study aimed to assess the clinical outcomes and risk factors for severe coronavirus disease 2019 (COVID-19) in patients with inflammatory rheumatic disease (IRD) of a national cohort. Patients and methods: The multicenter cross-sectional study was carried out between July 15, 2020, and February 28, 2021. Data collection was provided from a national network database system, and 3,532 IRD patients (2,359 males, 1,173 females; mean age: 48.7±13.9 years; range; 18 to 90 years) were analyzed. Demographics, clinics about rheumatic disease, comorbidities, smoking status, being infected with COVID-19, and the course of the infection were questioned by rheumatology specialists. Results: One hundred seventeen patients were infected with COVID-19, the hospitalization rate due to COVID-19 was 58.9%, and the mortality rate was 1.7%. There was no difference between the COVID-19 positive and negative groups in terms of rheumatic disease activities and receiving drugs. It was observed that patients with COVID-19 had worse compliance with isolation rules, and bacillus Calmette-Guérin (BCG) vaccination was less common. The mean age and the rate of smoking of hospitalized COVID-19 patients were higher than those without hospitalization. Conclusion: In this cohort, in which real-life data were analyzed, COVID-19 rates in IRD patients were similar to the general population for the same period. Compliance with the isolation rules and BCG vaccination attracted attention as components that reduce the risk of COVID-19 infection. The risk factors for hospitalization were older age and smoking.

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“…COVID-19 Saudi patients who were previously vaccinated against BCG and seasonal influenza were able to report higher changes in their HRQoL. It was reported that some BCG vaccine strains can be used as an additional defense in future pandemics [ 36 ]. The WHO and more than 20 European countries have already recommended the co-administration of influenza and COVID-19 vaccines [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of COVID-19 on the Health-Related Quality of Life of Patients during Infection and after Recovery in Saudi Arabia

Alanazi

Abdelgawwad²,

Almangour

et al. 2023

IJERPH

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This study evaluated the impact of COVID-19 and other factors on the health-related quality of life (HRQoL) of Saudi patients during infection and after recovery using the EQ-5D-5L and EQ-VAS instruments. An observational prospective study was conducted in November 2022, during which 389 COVID-19 patients were surveyed during their visit to a medical center. Two weeks after their recovery, they were contacted again to re-evaluate their HRQoL (192 patients either refused to participate or withdrew). The mean of the EQ-5D-5L index and EQ-VAS scores significantly increased from (0.69 ± 0.29 and 63.16 ± 24.9) during infection to (0.92 ± 0.14 and 86.96 ± 15.3) after recovery. Specifically, COVID-19 patients experienced improvement of several HRQoL dimensions post recovery, such as better mobility, enhanced self-care, returning to usual activities, less pain/discomfort, and alleviated anxiety/depression. Multiple linear regression analyses showed that having a normal weight, being employed, not being anemic, and previously taking the BCG vaccine were positively associated with a greater change in the HRQoL. An interaction between being asthmatic and taking the influenza vaccine positively predicted a lower change in the HRQoL. Having a normal weight positively predicted a greater change in the perceived health state after recovery. Increasing the consumption of natural supplements (honey and curcuma) did not improve the HRQoL or the perceived health state. Based on these findings, COVID-19 mildly impacted the HRQoL of Saudis with varying effects depending on some socio-demographic/clinical characteristics of the patients.

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Tuberculosis, BCG Vaccination, and COVID-19: Are They Connected?

Cited by 6 publications

References 0 publications

Long COVID and its Management

Long COVID and its Management

Pandemic of the century: COVID-19 in inflammatory rheumatic diseases of a national cohort with 3,532 patients

Impact of COVID-19 on the Health-Related Quality of Life of Patients during Infection and after Recovery in Saudi Arabia

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