Tuberculosis Case Notification and Treatment Outcomes in West Gojjam Zone, Northwest Ethiopia: A Five-Year Retrospective Study

Gebreegziabher, Senedu Bekele; Yimer, Solomon Abebe; Bjune, Gunnar

doi:10.4236/jtr.2016.41004

Cited by 30 publications

(41 citation statements)

References 19 publications

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“…In this study the mean age of TB case in Tigray was 36 years with SD±15 and in Zigong was 44years with SD±17. Tigray finding was similar with study done in sidama and Gojjam for general population (17, 20). And comparing with Zigong, younger women get infected in Tigray than Zigong and this could be the age distributions tuberculosis in Africa has been severely skewed by the human immunodeficiency virus epidemic (26).…”

Section: Resultssupporting

confidence: 89%

“…In this study, the overall treatment success rate of all TB cases was 92% in Tigray and 96.6% in Zigong. The finding of Tigray was similar with studies done in west Gojjam, Sidama and Addis Ababa 91.5% (17, 20, 37) the success rate for both sex. But, higher than the WHO report 89% for both sex (10) and the success of Zigong is higher than (10, 38, 39).…”

Section: Resultssupporting

confidence: 88%

“…Correspondingly, in this retrospective study the death of women and children in the past ten years were 170 [6 %] in Tigray and 36 [0.8%] in Zigong. The death toll in Tigray was higher than the annual report of the Regional Health Bureau for both sex 3.6% (33), retrospective study done in Gojjam for both sex 3.7% and global report of TB death for women and children 4.2% (10, 14, 17). In cases of Zigong it is similar with the global report for general population (10).…”

Section: Resultsmentioning

confidence: 92%

“…In Ethiopia Directly Observed Treatment (DOTS) was started in 1992 as a pilot and currently achieves 100 percent geographical coverage and recently 92% of public hospitals and health centers offer DOTS (19). The role of health facility in TB prevention and control was not centralized that means all hospitals and majority of health centers which have the diagnostic technology are allowed to diagnosis TB and providing DOTs service(17, 19, 20). Though, the role of health posts (village clinics) was limited only they provide health education, refer TB suspects for investigation and collect sputum smears, retrieve absentees/defaulters and in few place they can provide DOTs for case who is very far from health institution(21).…”

Section: Study Settings and Methodsmentioning

confidence: 99%

“…There are factors which identified as causes of unsuccessful treatment outcome for general population among these Retreatment cases, HIV co-infection, TB type and age were mentioned repeatedly however, this factors may not be found equally in all regions (17).…”

Section: Introductionmentioning

confidence: 99%

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Tuberculosis treatment outcome: The case of women in Ethiopia and China, Ten-Years Retrospective Cohort study

Gebremeskel

Bekele

et al. 2019

Preprint

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24Every year tuberculosis kills above half million women all over the world. Nonetheless, the 25 difference in the size of deaths among countries was not compared. Hence, this study is aimed to 26 compare the death size of two countries. Socio demographic and clinical data of women treated 27 for all form of tuberculosis in the past ten years 2007-2016 were collected from total of eight 28 hospitals and six treatment centers of Tigray and Zigong respectively. Then, collected data were 29 entered into SPSS version 21 then we estimated the magnitude of TB, level of treatment success 30 and assessed factors associated with the unsuccessful TB outcome. In the past ten years, a total 31 of 5603(41.5%) and 4527 (24.5%) tuberculosis cases were observed in Tigray and Zigong 32 respectively. Of those with treatment outcome record a total of 2602(92%) in Tigray and 33 3916(96.7%) in Zigong were successfully treated. Total of 170 (6%) cases in Tigray and 34 36(0.8%) cases in Zigong were dead. In Tigray cases like retreatment (aOR, 0.29; 95% CI: 0.16-35 0.53) and multi drug resistant (aOR, 0.31; 95% CI: 0.003, 0.27) were less likely to show 36 treatment success. But, HIV co-infected TB cases (aOR, 3.58; 95% CI: 2.47, 5.18) were more 37 likely to show treatment success. In Zigong, women with MDR TB (Adjusted OR, 0.90; 95%CI: 38 0.24, 0.34) were less likely to show treatment success. On the other hand women in the age 39 category of 15-49 (adjusted OR, 1.55; 95% CI: 1.08, 2.206) showed treatment success. Big 40 number of tuberculosis cases and death were observed in Tigray comparing with Zigong. Hence, 41 a relevant measure should be considered to improve treatment outcome of women in Tigray. 42 Key words: Tuberculosis, women, MDR-TB.43 44 3 45 Introduction 46Despite the discovery of effective and affordable chemotherapy (1) tuberculosis kills 1.5 million 47 people every year the death tall for women was 41.3% of the total death (2). The gender 48 difference in tuberculosis infection was not well understood. Nevertheless, TB kills more women 49 annually than all the causes of maternal mortality combined (2). In recent times, every year, at 50 least 3.5 million women and children develop active TB among these 1.2 million cases died and 51 more were left severely disabled (3-5). 52Globally implementation of Direct observed treatment [DOTs] were saved 2.2 million of women 53 and children (6) however there are enormous difference on the number of life saved and its 54 factors affecting among regions. Few reports and studies attempts to compare and display the 55 regional difference but the majorities were crude. For instance, WHO categorize Ethiopia and 56 China among high TB burden countries (7-9) but its prevalence and treatment success reports 57 were not specific for this group it tells about general population. Thus, the prevalence for 58 Ethiopia was 192/100,000 and 67/100,000 was for China (10, 11) and the treatment success rate 59 was 89% for Ethiopia and 94 % for China (10). In 2010 there was a regional report from ...

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Section: Resultssupporting

confidence: 89%

Section: Resultssupporting

confidence: 88%

Section: Resultsmentioning

confidence: 92%

Section: Study Settings and Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Tuberculosis treatment outcome: The case of women in Ethiopia and China, Ten-Years Retrospective Cohort study

Gebremeskel

Bekele

et al. 2019

Preprint

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Trends and outcomes of tuberculosis among cases on directly observed short course treatment (DOTS) at Tepi public health center Southwest Ethiopia

Getachew

Sirna

Terefe

et al. 2021

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

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Background Determining the trends and treatment outcomes of TB in health facilities is very important to inform better management of the disease and control efforts. Nevertheless, data from the rural, urban and suburban settings of Ethiopia show variability and inconsistency. This study was designed to evaluate trends and treatment outcomes of tuberculosis patients at Tepi Health Center and to identify the predictors of unsuccessful treatment outcome. Method Retrospective review of TB cases registered in Tepi health center between June 2011 and May 2018 was conducted using data extracted from medical records of TB patients. Structured data extraction form was prepared and used to extract socio-demographic, clinical and outcome data of study cases. Case definition and the treatment outcome of patients were ascertained and reported in accordance with World Health Organization guideline. Binary logistic regression model was fit to identify predictors of unsuccessful outcome. Results A total of 1651 TB patients registered at Tepi Public Health Center in between June 2011 and May 2018, were included in the study. Of all 924 (56%) were males and 1053 (63.8%) cases were in between the age range of 15 and 35 years. HIV-status of 1019 TB cases were unknown and 189 (11.4%) of participants were HIV-positive. Four hundred fifty seven (27.7%) cases were diagnosed with extra pulmonary TB (EPTB) and 1194 (72.3%) were pulmonary TB patients out of which, 376 (73.6%) were smear-positive pulmonary TB (PTB+). Overall treatment success rate (TSR) of patients was 80.4% (1327/1651), while it was 84.8% (134/158), 80.2% (410/511), and 78.3% (148/189) among the transfer-in, PTB+, and HIV + cases, respectively. Higher numbers of successful treatment outcomes were recorded among new patients (82.7%) and EPTB cases (84.7%). The cure rate were 73.6% (376/511) and 18% (34/189) among patients with PTB+ and HIV+, respectively. Multiple logistic regression analysis indicated that residence sites (OR 0.763 (0.584, 0.996) and TB/HIV co-infection (OR 0.661 (0.444, 0.985), were significantly associated with the treatment outcome. Rural residence was 27.1% less likely to have successful treatment. There was significant heterogeneity in the odds of having successful treatment outcomes across years of initiating treatment. Conclusion Treatment success rate among study cases was lower than the WHO’s target and further efforts like availability of TB clinics in nearby sites and reducing rate of HIV infection should be made to improve rate of successful treatment outcome.

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Tuberculosis treatment outcomes and associated factors among tuberculosis patients treated at healthcare facilities of Motta Town, Northwest Ethiopia: a five-year retrospective study

Limenh,

Kasahun,

Sendekie

et al. 2024

Sci Rep

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Tuberculosis (TB) remains a significant public health concern, particularly in low-resource settings. The treatment outcome is a crucial indicator of the effectiveness of TB treatment programs. Assessing the current treatment outcome and its associated factors is essential for improving patient care and reducing the spread of TB. Therefore, this study aimed to assess TB treatment outcomes and their associated factors among TB patients who received treatment at public healthcare facilities in Motta Town, Northwest Ethiopia. A facility-based retrospective cross-sectional study design was employed in two TB treatment centers in Motta town from January 2017 to December 2021. The study participants were all patients diagnosed with TB who received treatment. A p-value of 0.05 with a 95% confidence interval (CI) was used to determine statistical significance. A total of 362 TB patients were included in the study. The overall treatment success rate was 88.4% (95% CI 85.1, 91.7). Male gender (AOR = 2.40, 95% CI 1.16, 4.98), normal nutritional status (AOR = 3.11, 95% CI 1.33, 7.25), HIV negative status (AOR = 3.35, 95% CI 1.31, 8.60), and non-presumptive drug resistance to TB (AOR = 3.72, 95% CI 1.74, 7.98) were significantly associated with successful TB treatment outcomes (p < 0.05). In the current study, nine out of ten study participants had successful TB treatment outcome rates. Male gender, normal nutritional status, non-presumed drug resistance to TB, and HIV-negative status were significantly associated with successful TB treatment outcomes. By taking risk factors associated with poor treatment outcomes like those found in this study into account, patient management and treatment can be optimized. Sufficient TB control measures for populations are imperative and could significantly reduce the nation's total TB burden.

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Tuberculosis Case Notification and Treatment Outcomes in West Gojjam Zone, Northwest Ethiopia: A Five-Year Retrospective Study

Cited by 30 publications

References 19 publications

Tuberculosis treatment outcome: The case of women in Ethiopia and China, Ten-Years Retrospective Cohort study

Tuberculosis treatment outcome: The case of women in Ethiopia and China, Ten-Years Retrospective Cohort study

Trends and outcomes of tuberculosis among cases on directly observed short course treatment (DOTS) at Tepi public health center Southwest Ethiopia

Tuberculosis treatment outcomes and associated factors among tuberculosis patients treated at healthcare facilities of Motta Town, Northwest Ethiopia: a five-year retrospective study

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