Tuberculosis due to Mycobacterium bovis in humans in the south-west region of ireland: Is there a relationship with infection prevalence in cattle?

Cotter, T. P.; Sheehan, S.; Cryan, B.; O'Shaughnessy, E.; Cummins, Helen; Bredin, C. P.

doi:10.1016/s0962-8479(96)90053-2

Cited by 15 publications

(7 citation statements)

References 11 publications

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“…In our study, 81% of patients infected were >30 years of age (Table 2), comparable with fi ndings of a previous survey of the southwest Ireland population (5). Primary infection of this group is likely to have been several decades before diagnosis, and our isolates probably represent reactivation of disease acquired earlier in life, effectively a record of past prevalence in animals.…”

Section: Discussionsupporting

confidence: 89%

Mycobacterium bovisStrains Causing Smear-Positive Human Tuberculosis, Southwest Ireland

Ojo¹,

Sheehan²,

Corcoran³

et al. 2008

Emerg. Infect. Dis.

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Mycobacterium bovis caused 3% of human tuberculosis cases in southwest Ireland during 1998–2006. Of 11 M. bovis strains genotyped, 9 belonged to common animal spoligotypes. Seven strains were from sputum and potential sources of human-centered disease transmission. Ten-locus variable-number tandem repeat typing gave unique strain profiles and would detect disease outbreaks.

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Section: Discussionsupporting

confidence: 89%

Mycobacterium bovisStrains Causing Smear-Positive Human Tuberculosis, Southwest Ireland

Ojo¹,

Sheehan²,

Corcoran³

et al. 2008

Emerg. Infect. Dis.

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“…On the other hand, surpassing a previously thought host preference [34], Mtb infected cattle has been reported in countries with high incidence of bTB [16, 105]. Defining the proportion as well as the clinical presentation of infected subjects (active or persistent) in affected countries is no doubt of enormous importance, as it is determining the same numbers for infected cattle [22]. …”

Section: Introductionmentioning

confidence: 99%

Molecular findings and approaches spotlightingMycobacterium bovispersistence in cattle

Álvarez¹,

Estrada-Chávez²,

Flores-Valdéz³

2009

Vet. Res.

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Mycobacterium tuberculosis (Mtb) and Mycobacterium bovis (M. bovis) are the etiological agents of human and bovine tuberculosis (TB, bTB) respectively, and share genetic identity over 99% at the whole genome level. Progress has been made towards explaining how mycobacteria and their infected hosts remain in balance without producing clinical symptoms of disease, a phenomenon referred to as latency or persistence, which can be mimicked by certain in vitro conditions. Latency/persistence has mainly been studied using Mtb, where the two-component signalling system, dosRS, has been assigned an instrumental role, and even constitutes the current basis for development of new diagnostic methods and treatment addressing this particular stage of TB. M. bovis conserves homolog genes that in Mtb play a role in human latent TB infection and that, by analogy, would allow it to enter a persistent state in infected cattle; nevertheless, little attention has been paid to this stage in bovine hosts. We suggest that many of the advances acquired through the study of Mtb can and should be taken into consideration by research groups and veterinary professionals dealing with bTB. The study of the infection in bovines, paying particular attention to defining the molecular and cellular markers of a M. bovis persistent infection in cattle, presents great opportunities for the development and trial of new diagnostic tests and vaccines, tools that will surely help in promoting eradication of bTB in high-burden settings.

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“…Prior to national control measures, disease in cattle was common. From 1929 to 1938, it was estimated that gross pathology consistent with tuberculosis was present in 31-33% of cattle slaughtered at the city abattoirs in Dublin [7]. A national eradication programme commenced in 1954, in part as a consequence of public health concerns, leading to a substantial reduction in disease prevalence by the mid 1960s [16].…”

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confidence: 99%

An outbreak of tuberculosis affecting cattle and people on an Irish dairy farm, following the consumption of raw milk

Doran

Carson

Costello³

et al. 2009

Ir Vet J

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Bovine tuberculosis is an ongoing problem in Ireland, and herd incidence has remained at approximately 5% for some years. Spillover of infection from cattle to people remains an ever-present possibility, given the ongoing pool of infection in the Irish cattle population. This paper describes an outbreak of tuberculosis affecting cattle and people on a dairy farm in southeastern Ireland following the consumption of milk from a seven-year-old cow with tuberculous mastitis. Twenty-five of 28 calves born during autumn 2004 and spring 2005 were subsequently identified as TB reactors, and five of six family members were positive on the Mantoux test. During 2005, milk from this cow had mainly been used to feed calves, and was added only occasionally to the bulk tank. Therefore, the calves each received infected milk on an almost continuous basis between birth and weaning. The family collected milk from the bulk milk tank, and consumed it without pasteurisation. This case highlights the risks associated with the consumption of raw milk. In this family, TB has had a very significant impact on the health of two young children. These risks are well recognised, and relevant information for farmers is available. It is of concern, therefore, that raw milk consumption remains prevalent on Irish farms. New strategies are needed, in partnership with industry, to address this important issue. Keywords: bovine tuberculosis, Ireland, mastitis, milk, Mycobacterium bovis, pasteurisation, TB, zoonosis

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Tuberculosis due to Mycobacterium bovis in humans in the south-west region of ireland: Is there a relationship with infection prevalence in cattle?

Cited by 15 publications

References 11 publications

Mycobacterium bovisStrains Causing Smear-Positive Human Tuberculosis, Southwest Ireland

Mycobacterium bovisStrains Causing Smear-Positive Human Tuberculosis, Southwest Ireland

Molecular findings and approaches spotlightingMycobacterium bovispersistence in cattle

An outbreak of tuberculosis affecting cattle and people on an Irish dairy farm, following the consumption of raw milk

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