Tuberculosis: First in Flight

Fennelly, Kevin P.; Martínez, Leonardo; Mandalakas, Anna M.

doi:10.1164/rccm.202111-2513ed

Am J Respir Crit Care Med

2022

DOI: 10.1164/rccm.202111-2513ed

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Tuberculosis: First in Flight

Kevin P. Fennelly

Leonardo Martínez

Anna M. Mandalakas

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2024

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Cited by 2 publications

References 18 publications

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Whispers in the Wind: Face Mask Sampling for Mycobacterium tuberculosis Detection in Children With Pulmonary Tuberculosis

Meiwes,

Kontsevaya,

Chesov

et al. 2024

The Journal of Infectious Diseases

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Background Recently, face mask sampling (FMS) confirmed detection of Mycobacterium tuberculosis DNA from exhaled breath in adults with TB. To date, no study has evaluated the use of FMS to detect pulmonary Tuberculosis (TB) in children. We developed a method for FMS of M. tuberculosis-specific DNA in children and performed a clinical exploration to assess feasibility in children. Methods Face masks were spiked, analysed on GeneXpert-Ultra, qPCR, and tNGS. Children with pulmonary TB were asked to wear three modified FFP2 masks for 30 minutes as part of an exploratory clinical study. Results Experiments with H37Ra M. tuberculosis strain showed a limit of 95% detection of 3.75 CFU (4.85-3.11; 95%CI) on GeneXpert-Ultra. Ten children with pulmonary TB participated in the clinical study. M. tuberculosis-specific DNA was detected on none of the face masks. Conclusions Paediatric FMS has a low limit of detection for M. tuberculosis-specific DNA in vitro. However, M. tuberculosis DNA was not detected in any of thirty masks worn by children with pulmonary TB. This suggests that FMS in this form may not be more effective for detecting M. tuberculosis in children with TB than existing methods.

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Whispers in the Wind: Face Mask Sampling for Mycobacterium tuberculosis Detection in Children With Pulmonary Tuberculosis

Meiwes,

Kontsevaya,

Chesov

et al. 2024

The Journal of Infectious Diseases

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Análise Espacial Dos Casos De Tuberculose Em Um Estado Da Amazônia Ocidental Brasileira: Estudo Clínico-Epidemiológico

Santos,

Fonseca

2024

Rev. Contemp.

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A tuberculose, causada pela Mycobacterium tuberculosis, afeta principalmente os pulmões e é transmitida pelo ar, por meio de gotículas expelidas por pessoas infectadas. Os sintomas incluem tosse persistente, febre, sudorese noturna e perda de peso. Este estudo teve como objetivo caracterizar o perfil clínico e epidemiológico da tuberculose no estado do Amazonas, entre 2019 e 2023, com base nos dados do SINAN. Foram notificados 20.975 casos, com predominância masculina (62,5%) e maior incidência na faixa etária de 20 a 39 anos (43%). Fatores associados à doença incluíram alcoolismo (16,4%), uso de drogas (13,2%), tabagismo (15,8%), diabetes (10,3%) e HIV (12,2%). A confirmação laboratorial foi de 74,8% dos casos, e 55,2% evoluíram para a cura. O estudo visa contribuir para políticas de saúde e práticas clínicas, auxiliando no controle da tuberculose e sua carga global de morbidade e mortalidade.

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Tuberculosis: First in Flight

Cited by 2 publications

References 18 publications

Whispers in the Wind: Face Mask Sampling for Mycobacterium tuberculosis Detection in Children With Pulmonary Tuberculosis

Whispers in the Wind: Face Mask Sampling for Mycobacterium tuberculosis Detection in Children With Pulmonary Tuberculosis

Análise Espacial Dos Casos De Tuberculose Em Um Estado Da Amazônia Ocidental Brasileira: Estudo Clínico-Epidemiológico

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