Tuberculosis in australia: An analysis of cases identified in reference laboratories in 1986-88

Dawson, David J.; Anargyros, Peter; Blacklock, Zeta M.; Chew, William; Dagnia, Harvey; Gow, B.L.; Jackson, K.; Sievers, Aina

doi:10.3109/00313029109060811

Cited by 11 publications

(4 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Australia, the incidence of TB is low by international standards. Since 1989, the annual incidence of laboratory-confirmed cases has remained between 3 and 4 cases per 100,000 population (2)(3)(4)(5), and the rate of drug resistance is less than 18%. The majority of the drug-resistant infections involved either streptomycin or isoniazid alone or in combination with other antibiotics excluding rifampin.…”

mentioning

confidence: 99%

Bacteriological and Molecular Analysis of Rifampin-Resistant Mycobacterium tuberculosis Strains Isolated in Australia

Yuen

David²,

Coloe

1999

J Clin Microbiol

View full text Add to dashboard Cite

To develop a better understanding of the epidemiology and molecular biology of rifampin-resistant Mycobacterium tuberculosisstrains in Australia, 50 clinical isolates (33 rifampin-resistant and 17 rifampin-sensitive strains) cultured between 1990 and 1997 were analyzed by a number of bacteriological and molecular techniques. Examination of the drug resistance profiles of the 33 rifampin-resistant isolates revealed that 91% were resistant to rifampin in combination with resistance to isoniazid, 88% were resistant to rifampin on first isolation, and 81% showed cross-resistance with rifabutin. On the basis of the demographic data provided for the patients infected with the rifampin-resistant strains, 90% of the patients were born overseas. Of these patients, 64% developed clinical symptoms within 5 years of residence in Australia. On a molecular level, analysis of the rpoB gene revealed that 97% of the rifampin-resistant isolates had missense mutations within a conserved region of the gene, and eight types of missense mutations were detected. Of the 31 rifampin-resistant isolates that were typed by restriction fragment length polymorphism (RFLP) analysis, 28 distinct patterns were obtained by RFLP analysis with IS6110, and three clusters of genetically related isolates were identified. All isolates within the clusters were from patients who were born overseas and who had the same country of origin. The results from this study provide an overview of the current situation of rifampin resistance in Australia and can serve as a basis for continued monitoring of drug-resistant M. tuberculosis strains isolated within the country.

show abstract

mentioning

confidence: 99%

Bacteriological and Molecular Analysis of Rifampin-Resistant Mycobacterium tuberculosis Strains Isolated in Australia

Yuen

David²,

Coloe

1999

J Clin Microbiol

View full text Add to dashboard Cite

show abstract

“…Despite the decline in the incidence of tuberculosis in highly industrialized nations over the past 50 years, the disease remains a major health problem in the world today. In Australia alone, approximately 600 new cases are still diagnosed annually (2).…”

mentioning

confidence: 99%

Characterization of Mycobacterium tuberculosis strains from Vietnamese patients by Southern blot hybridization

et al. 1993

View full text Add to dashboard Cite

show abstract

“…In our survey there were 48 bacteriologically-positive cases in the years 1986-1988, which represents 8.5% of the 562 culture positive cases diagnosed in the Victorian reference laboratory for that period. 6 The most important finding is that an increasing proportion of patients with T B were born in Asia (Table 1). As well as the increasing numbers, there were four 9 additional important differences in TB in this group, compared to those born in Australia; (2) a younger age at diagnosis (Table 2) leading to a downward shift in the age distribution since 1980 ( Figure 1); (iz) a higher proportion of patients with drug resistant disease ( Table 4); (iiz) a lower proportion of pulmonary disease (Table 2); and (iw) lymph node disease as the predominant type of extrapulmonary TB.…”

Section: Discussionmentioning

confidence: 98%

Culture‐positive tuberculosis at St Vincent's Hospital, Melbourne, 1962–1989

Hurley

Uren

Andrew

et al. 1993

Australian and New Zealand Journal of Medicine

View full text Add to dashboard Cite

The disease type and demography of patients with culture confirmed tuberculosis (TB) diagnosed at St Vincent's Hospital, Melbourne between the years 1962 to 1989 were reviewed. Four hundred and eighty-two patients with culture-positive TB were identified whose origins were as follows: Australia 194; Northern Europe 38; The Mediterranean 98; Asia 60 and other or unknown 92. Patients whose country of birth was in Asia or the Mediterranean area accounted for 57% of patients in the 1980s; they presented at a younger age, with a higher proportion of extrapulmonary disease and a more equal sex distribution than did Australian born patients. The main types of extrapulmonary disease also differed for the various ethnic groups. The overall proportion of patients with an isolate resistant to at least one of the anti-TB drugs was 10.0% but in the Asian born was 21.7%. This survey, the longest series of bacteriologically confirmed cases of TB reported from a single institution in Australasia, has identified several changes in how TB is presenting for diagnosis.

show abstract

Tuberculosis in australia: An analysis of cases identified in reference laboratories in 1986-88

Cited by 11 publications

References 4 publications

Bacteriological and Molecular Analysis of Rifampin-Resistant Mycobacterium tuberculosis Strains Isolated in Australia

Bacteriological and Molecular Analysis of Rifampin-Resistant Mycobacterium tuberculosis Strains Isolated in Australia

Characterization of Mycobacterium tuberculosis strains from Vietnamese patients by Southern blot hybridization

Culture‐positive tuberculosis at St Vincent's Hospital, Melbourne, 1962–1989

Contact Info

Product

Resources

About