Tuberculosis in Ibaddan, Nigeria - a 30 year review

Nwachokor, F N; J, Thomas

doi:10.4314/cajm.v46i11.8571

Cited by 10 publications

(5 citation statements)

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“…This corroborates the earlier report that infected mother-caregivers were the major route of transmission and spread of the Childhood MDR TB. [30][31][32] This survey also showed that more males were infected and treated for the MDR-TB than the females, similar to studies from Malaysia and Morocco. 33,34 The treatment outcome in this study was poorer among We also noted the treatment outcome for the MDR-TB patients with resistance to…”

Section: Discussionsupporting

confidence: 76%

Predictors of Intensive Phase Treatment Outcomes among Patients with Multi-Drug Resistant Tuberculosis in Zaria, North-Western Nigeria

Oyefabi¹,

Adelekan²,

Adetiba³

et al. 2020

J. Com. Med. and PHC

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Background: The emergence of multidrug-resistant tuberculosis (MDR-TB) is a threat to successful TB treatment outcomes in developing nations like Nigeria. This study determined the predictors of intensive phase treatment outcomes in MDR-TB patients in Zaria, Nigeria.Methods: This was a retrospective cross-sectional review of the records of 124 MDR-TB patients registered between September 2012 and August 2017 at the National Tuberculosis and Leprosy Training Centre, Saye, Zaria. Data were analyzed using IBM SPSS version 25.0 and the StataCorp STATA/SE 14.Results: The median age (IQR) of the respondents was 32 (15) years. The gene Xpert test detected Mycobacterium Tuberculosis (MTB) and rifampicin resistance (RIF) in 119 (96.0%) cases. The treatment success rate was 97 (78.2%). MDR-TB and HIV co-infection rate was 17 (13.7%) while the case fatality rate was 16.1%. Bivariate analysis showed that being male (p=0.001), not currently in marital union (p=0.01) and positive smear results at 1 month (p=0.027)) were significantly associated with treatment success. Multivariate logistic regression showed that the odds for successful treatment outcome was 4 times higher for the MDR-TB patients who were employed than the unemployed (AOR= 3.98, 95% CI= 1.15-13.74). No significant relationship between MDR-TB-HIV comorbidity (AOR=1.89, 95% CI=0.44-8.19), MDR-TB susceptible to Isoniazid (AOR= 0.49, 95% CI =0.15-1.56) and successful treatment outcome.Conclusion: Unemployment was a predictor of poor treatment outcome in this study. Cause-specific mortality due to the MDR TB was high in this setting. We advocate for optimization of access to treatment and social support system, especially for the female patients. Keywords: Gene Xpert; Intensive phase; MDR-TB; Treatment outcomes; Nigeria.

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Section: Discussionsupporting

confidence: 76%

Predictors of Intensive Phase Treatment Outcomes among Patients with Multi-Drug Resistant Tuberculosis in Zaria, North-Western Nigeria

Oyefabi¹,

Adelekan²,

Adetiba³

et al. 2020

J. Com. Med. and PHC

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“…Genital tuberculosis (TB) predominantly affects individuals below 40 years of age and peak age frequency ranges between 21 to 30 year of age. 1 The disease is responsible for 5% of all female pelvic infections and occurs in 10% cases of pulmonary tuberculosis. Gupta et al, studied 40 infertile women with genital tuberculosis and found pulmonary tuberculosis in 9 of them and positive Mantoux test results in two patients.…”

Section: Introductionmentioning

confidence: 99%

A Ten year Clinicopathological Study of Female Genital Tuberculosis and Impact on Fertility

Mondal

Dutta

2008

J Nepal Med Assoc

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INTRODUCTION:To determine the histological pattern of involvement, clinical presentation, impact on fertility in women with genital tuberculosis.METHODS:A total number of 68 cases of gynaecological tuberculosis affecting different parts of female genital tract from 56 patients were selected. The age range of the patients was 17-36 years with mean age of 25.6 years. The diagnostic procedures used included endometrial curettage and biopsy, histopathological examination, culture and Mycobacterium Tuberculosis Polymerase Chain Reaction (MTB PCR), laparoscopy, Hysterosalpingography (HSG) and Ultrasonography (USG). Most of the specimens received were biopsies of endometrial curettage for evaluation of infertility. In 7 cases, specimens of total hysterectomy with bilateral salpingo-oophorectomy were submitted with lesions involving multiple sites.RESULTS:Patients presented with infertility (65-70%), pelvic/abdominal pain (50-55%), and menstrual disturbances (20-25%). Tuberculosis involved the endometrium in 55.88%, tubes in 23.53%, ovaries in 14.71% and cervix in 5.88% of the 68 cases. The endometrium(38 cases)was in the proliferative phase in 31 cases (81.57%), secretory phase in 4 cases (10.52%) and it was atrophic in 3 cases (7.89%).Caseation was present in 9 out of 68 cases and Ziehl-Neelsen (ZN) stain revealed Acid Fast Bacilli (AFB) in tissue sections in only 4 cases . After therapy, 9 patients conceived of which 8 suffered spontaneous abortions. Only one patient had a successful pregnancy and the baby was born through caesarean section.CONCLUSIONS:Genital tuberculosis is an important cause of female infertility in developing countries like India, Nepal, Bangladesh and Pakistan. Successful uterine pregnancy is rare after treatment and chances of ectopic pregnancy are high.Keywords: Key Words:female infertility, genital tuberculosis, histology

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“…Ibadan, the capital of Oyo State, has a population of approximately 1.3 million and is a major trade route between the southern ports and rest of Nigeria. Previous studies have investigated the burden of tuberculosis in this area, with Nwachokor and Thomas reviewing data for the Ibadan area from 1966 to 1995 (15). They found that, from 1981 to 1995, there was an increase in tuberculosis in this region, with socioeconomic factors and poor health care contributing to this rise.…”

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confidence: 99%

Molecular Analysis of Human and Bovine Tubercle Bacilli from a Local Setting in Nigeria

et al. 2006

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To establish a molecular epidemiological baseline for the strains causing tuberculosis in Nigeria, a survey of isolates from humans and cattle was carried out. Spoligotyping and variable-number tandem-repeat analysis revealed that the majority of tuberculosis disease in humans in Ibadan, southwestern Nigeria, is caused by a single, closely related group of Mycobacterium tuberculosis strains. Using deletion typing, we show that approximately 13% of the disease in humans in this sample was caused by strains of Mycobacterium africanum and Mycobacterium bovis rather than M. tuberculosis. Molecular analysis of strains of M. bovis recovered from Nigerian cattle show that they form a group of closely related strains that show similarity to strains from neighboring Cameroon. Surprisingly, the strains of M. bovis recovered from humans do not match the molecular type of the cattle strains, and possible reasons for this are discussed. This is the first molecular analysis of M. tuberculosis complex strains circulating among humans and cattle in Nigeria, the results of which have significant implications for disease control.

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Tuberculosis in Ibaddan, Nigeria - a 30 year review

Cited by 10 publications

References 0 publications

Predictors of Intensive Phase Treatment Outcomes among Patients with Multi-Drug Resistant Tuberculosis in Zaria, North-Western Nigeria

Predictors of Intensive Phase Treatment Outcomes among Patients with Multi-Drug Resistant Tuberculosis in Zaria, North-Western Nigeria

A Ten year Clinicopathological Study of Female Genital Tuberculosis and Impact on Fertility

Molecular Analysis of Human and Bovine Tubercle Bacilli from a Local Setting in Nigeria

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