Tuberculosis infection and epidemiological characteristics in Haidian District, Beijing, 2005–2018

Wu, Fan; Zhang, Gaoqiang; Li, Yueqi; Yu, Shuai; Peng, XiuFan; Yang, Jiani; Wei, Zhisheng; Zhang, Wenjuan

doi:10.1186/s12889-020-08773-8

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…However, our study revealed that 41.7% of patients still experience a delay, and 35.2% of patients encountered a delay in diagnosis. Another study from the Haidian counties of Beijing reported a 54.96% rate of diagnostic delay ( 31 ). Our study showed a lower rate of diagnostic delay.…”

Section: Discussionmentioning

confidence: 99%

Analysis of care-seeking and diagnosis delay among pulmonary tuberculosis patients in Beijing, China

Zhang,

Ma,

Gao

et al. 2024

Front. Public Health

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BackgroundTuberculosis (TB) remains a significant public health challenge in China. Early detection and diagnosis of TB cases are crucial to interrupt disease transmission and prevent its progression. This study aims to describe the delay in seeking care and diagnosis among patients with pulmonary tuberculosis (PTB) and identify the influencing factors in two counties in Beijing.MethodsA retrospective analysis was carried out to investigate care-seeking and diagnosis delay in two counties in Beijing. Basic information of PTB patients from January 1 to December 31, 2021, was extracted from the Tuberculosis Information Management System of China (TBIMS), and all enrolled patients were interviewed via telephone using a standard questionnaire. Statistical description was performed using the median and interquartile range (IQR). Chi-square test and multivariate logistic regression model were used to analyze the influencing factors.Results537 patients were enrolled. The median duration of care-seeking and diagnosis delay was 11 (IQR: 5–26) days and 8 (IQR: 0–18) days, with 41.71 and 35.20% of patients experiencing delays (>14 days). The study found that being asymptomatic (OR = 2.791, 95%CI: 1.710–4.555) before seeking medical care and not attending work during treatment (OR = 2.990, 95%CI: 1.419–6.298) were identified as risk factors for care-seeking delay. Patients who were tracked (OR = 2.632, 95%CI: 1.062–6.521) and diagnosed at tuberculosis control and prevention institutions (OR = 1.843, 95%CI: 1.061–3.202) had higher odds of diagnostic delays. 44.69% of patients presented a total delay (>28 days), with a median duration of 25 (IQR: 13–39) days. A multivariate logistic regression analysis showed that healthy examination (OR = 0.136, 95%CI: 0.043–0.425) was a protective factor for total delay.ConclusionPublic interventions are necessary to improve the efficiency of PTB patients detection and treatment in Beijing. Medical services should focus on the target population and improve access to medical care to further reduce delays for PTB patients.

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Section: Discussionmentioning

confidence: 99%

Analysis of care-seeking and diagnosis delay among pulmonary tuberculosis patients in Beijing, China

Zhang,

Ma,

Gao

et al. 2024

Front. Public Health

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“…The thresholds were close to the median durations of patient delay (28 days [95% CI 20–30]) and hospital delay (14 days [95% CI 2–28]) in a meta-analysis ( 16 ). Some studies in China defined the patient delay of over 2 weeks from the syndrome onset to the first care-seeking and estimated 46.4 and 59.0% of the TB patients had delays in Beijing ( 17 ) and Hubei ( 18 ), respectively. The levels were slightly lower than that of Shenzhen-−59.0% under the 2-week threshold.…”

Section: Discussionmentioning

confidence: 99%

Time-trend analysis of tuberculosis diagnosis in Shenzhen, China between 2011 and 2020

Chuangyue

Wang

Zhang

et al. 2023

Front. Public Health

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ObjectiveTo describe the trend of tuberculosis (TB) diagnosis in the migrant city Shenzhen, China, and analyze the risk factors of diagnosis delays.MethodsDemographic and clinical information of TB patients from 2011 to 2020 in Shenzhen were extracted. A bundle of measures to enhance TB diagnosis had been implemented since late 2017. We calculated the proportions of patients who underwent a patient delay (>30 days from syndrome onset to first care-seeking) or a hospital delay (>4 days from first care-seeking to TB diagnosis). Multivariable logistic regression was used to analyze the risk factors of diagnosis delays.ResultsDuring the study period, 43,846 patients with active pulmonary TB were diagnosed and registered in Shenzhen. On average, the bacteriological positivity rate of the patients was 54.9%, and this increased from 38.6% in 2017 to 74.2% in 2020. Overall, 30.3 and 31.1% of patients had a patient delay or a hospital delay, respectively. Molecular testing significantly increased bacteriological positivity and decreased the risk of hospital delay. People >35 years old, the unemployed, and residents had a higher risk of delays in both patient care-seeking and hospital diagnosis than younger people, workers, or migrants. Compared with passive case-finding, active case-finding significantly decreased the risk of patient delay by 5.47 (4.85–6.19) times.ConclusionThe bacteriological positivity rate of TB patients in Shenzhen increased significantly but the diagnosis delays were still serious, which may need more attention when active case-finding in risk populations and optimization of molecular testing.

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“…This means that 1.1 million children become ill with TB every year, almost half of them below five years of age ( 10 ). According to a previous report in Beijing, the average annual TB morbidity was 31.67/10,000 ( 11 ). Although mycobacterium tuberculosis (Mtb) infected individuals have a possibility of 5%–10% to develop active TB, immunosuppressive therapy by glucocorticoids, TNF-alpha inhibitors, and some others, have been proved to increase the risk of active TB disease in latent tuberculosis infection (LTBI) individuals.…”

Section: Introductionmentioning

confidence: 99%

Performance of two interferon-gamma release assays for tuberculosis infection screening in Kawasaki children before immunosuppressive therapy

et al. 2023

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ObjectiveWe aimed to compare QuantiFERON-TB Gold In-Tube (QFT-GIT) and X.DOT-TB for screening latent tuberculosis infection (LTBI) in kawasaki patients, and to identify the risk factors associated with indeterminate IGRA results.MethodsWe conducted a retrospective study on children with KD, who were screened for mycobacterium tuberculosis (Mtb) infection by either ELISA-based QFT-GIT or ELISPOT-based X.DOT-TB tests, admitted in Department of Cardiology, Beijing Children's Hospital from July 2019 to April 2022.ResultsA total of 1327 cases were included. Among them, 932 cases were tested by QFT-GIT and 395 cases by X.DOT-TB. The positive rate of children was 0.1% and 0.2%, and the indeterminate rate was 68.2% and 6.1% for QFT-GIT and X.DOT-TB, respectively. Patients with hypoproteinemia had a higher risk of indeterminate X.DOT-TB result. Female, critical ill, shock or hypoproteinemia presented statistically significant associations with an increased risk of indeterminate QFT-GIT result. High-dose of IVIG inhibited the release of IFN-γ by more than 90%, which might account for the high indeterminate incidence.ConclusionIt is recommended to perform X.DOT-TB rather than QFT-GIT to screen LTBI in patients with high level of the mitogen that can inhibit IFN-γ release. For KD children with positive IGRA results, it has a higher risk of activation TB infection when treated with immunosuppressive therapy in the future. Children with KD aged <5 years old had higher frequency of indeterminate IGRA results.

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Tuberculosis infection and epidemiological characteristics in Haidian District, Beijing, 2005–2018

Cited by 6 publications

References 14 publications

Analysis of care-seeking and diagnosis delay among pulmonary tuberculosis patients in Beijing, China

Analysis of care-seeking and diagnosis delay among pulmonary tuberculosis patients in Beijing, China

Time-trend analysis of tuberculosis diagnosis in Shenzhen, China between 2011 and 2020

Performance of two interferon-gamma release assays for tuberculosis infection screening in Kawasaki children before immunosuppressive therapy

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