Tuberculosis of the Breast

Kakkar, Sunita; Kapila, Kusum; Singh, Manoj Kumar; Verma, Kusum

doi:10.1159/000328467

Cited by 100 publications

(37 citation statements)

References 7 publications

(9 reference statements)

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“…The histologic picture of IGM in our series resembles those described in other studies with noncaseating granulomas centered in mammary lobules, being formed of epithelioid histiocytes, neutrophils, lymphocytes, and plasma cells with or without multinucleated giant cells [13,16,21,37]. An additional histologic finding, i.e.…”

Section: Discussionsupporting

confidence: 83%

“…With regard to FNAC in tuberculous mastitis, the smears usually show epithelioid giant-cell granulomas with or without caseation necrosis [38,39]. We do not agree with Kakkar et al [37], who mentioned that IGM is indistinguishable from tuberculous mastitis on cytologic grounds. Neutrophils are usually abundant in IGM, while in tuberculous mastitis they are usually absent [38].…”

Section: Discussioncontrasting

confidence: 77%

“…This picture is clearly different from that of fat necrosis, in which foamy histiocytes are predominant and neutrophils are absent [36]. Also, duct ectasia is characterized by foamy histiocytes and the absence of neutrophils and epithelioid histiocytes [37]. With regard to FNAC in tuberculous mastitis, the smears usually show epithelioid giant-cell granulomas with or without caseation necrosis [38,39].…”

Section: Discussionmentioning

confidence: 99%

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Idiopathic Granulomatous Mastitis: Cytologic and Histologic Study of 65 Egyptian Patients

Helal

Shash²,

El-Din³

et al. 2016

Acta Cytologica

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Background: The etiology of idiopathic granulomatous mastitis (IGM) is unknown, and it is commonly misdiagnosed clinically and/or radiologically as breast cancer. The role of fine-needle aspiration cytology (FNAC) in its diagnosis is still a matter of debate. The aim of the current study is to assess the value of FNAC in the diagnosis of IGM, and to search for the presence of bacteria in IGM with cystic vacuoles, which was described recently by a few authors. Materials and Methods: Retrospective study of cytologic smears and histologic tissue sections of 65 Egyptian IGM cases was done along with microbiologic testing. A comparison of the frequency of IGM in Egypt to that of other populations was also made. Results: IGM has typical FNA features which can easily exclude malignancy. Histologically, cystic vacuoles were encountered in 35 out of 65 cases (53.9%), with only 6 (17.14%) of these cases showing Gram-positive bacilli (GPB). The frequency of IGM in Egypt is comparable to those in other Middle Eastern countries but much higher than in Western countries. Conclusion: IGM is a common breast disease in Egypt. FNAC in IGM has a high diagnostic accuracy. This study supports the few recent studies that have detected GPB in IGM with cystic vacuoles. Thus, bacteriologic examination in such cases may affect the treatment strategy.

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Section: Discussionsupporting

confidence: 83%

Section: Discussioncontrasting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Idiopathic Granulomatous Mastitis: Cytologic and Histologic Study of 65 Egyptian Patients

Helal

Shash²,

El-Din³

et al. 2016

Acta Cytologica

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“…It comprises 3% of all breast diseases and is 5 times less common than carcinoma of the breast [4]. It can be classified as primary when no demonstrable tuberculous focus exists, or it can be secondary to a lesion elsewhere in the body [5,6]. Breast TB almost exclusively affects women and occurs mostly in multiparous lactating women between the ages of 20 and 40 years [7].…”

Section: Discussionmentioning

confidence: 99%

Postmenopausal Breast Tuberculosis Report of 4 Cases

Bouti¹,

Soualhi²,

Marc³

et al. 2012

Breast Care

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Background: Breast tuberculosis is an uncommon disease even in countries where the incidence of tuberculosis is high. Case Report: This is a case series concerning 4 postmenopausal breast tuberculosis cases encountered in Moulay Youssef Hospital between January 2007 and December 2010. Breast tuberculosis represents 0.25% of all hospitalized tuberculosis patients in our department. The mean age of our patients was 62.5 ± 5.8 years. Clinical findings were heterogeneous; 1 case was multifocal tuberculosis, and another case was coexistent tuberculosis and malignancy of the breast. Mammography and ultrasonography findings were suspicious for malignancy in all 4 cases. Fine needle aspiration was negative in 3 cases. The diagnosis was made in all patients by histological examination of biopsy specimens, which revealed typical tuberculous lesions. Antituberculosis therapy formed the mainstay of treatment. Conclusion: The clinical and radiological features of mammary tuberculosis can be very confusing and easily mistaken for breast cancer. Symptoms suggestive of tuberculosis warrant a biopsy to exclude possible cancer.

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“…К первичной форме туберкулеза МЖ наиболее восприимчивы женщины репродук-тивной возрастной группы от 21 до 40 лет, осо-бенно в период лактации в связи с внутрипро-токовым инфи¬цированием [7]. Вторичная форма туберкулеза молочной железы развива-ется вследствие гематогенной диссеминации (лёгкие, средостение), ретроградного распро-странения из лимфатических узлов подмышеч-ной области и из прилежащих к молочной желе-зе смежных структур: из грудины, ребер, плече-вых суставов [8].…”

Section: Introductionunclassified