Tuberculosis of The Central Nervous System

Gauba, Charu; Varma, Mukul

doi:10.1016/s0976-0016(12)60056-8

Cited by 6 publications

(20 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…for 5-15% of extra-pulmonary TB cases [43][44][45][46][47][48]. CNS TB usually results from hematogenous dissemination of TB bacteria from a primary location outside the CNS (such as the lungs or the gastrointestinal tract) and is characterized by a slowly progressive granulomatous inflammatory reaction that may affect the meninges, or the brain or spinal cord parenchyma [43,[49][50].…”

Section: Plos Onementioning

confidence: 99%

“…The disease develops in two stages [43,45,48,51]. The initial stage involves the formation of small (0.5-2 mm) tubercles − also known as Rich foci − around TB bacteria deposited in the CNS via blood circulation during or shortly after the bacteremic stage of primary infection or late reactivation of TB elsewhere in the body [43][44][45][46]48,[51][52][53][54]. Following their establishment, Rich foci may remain dormant for many years [43][44][45][52][53].…”

Section: Plos Onementioning

confidence: 99%

“…The initial stage involves the formation of small (0.5-2 mm) tubercles − also known as Rich foci − around TB bacteria deposited in the CNS via blood circulation during or shortly after the bacteremic stage of primary infection or late reactivation of TB elsewhere in the body [43][44][45][46]48,[51][52][53][54]. Following their establishment, Rich foci may remain dormant for many years [43][44][45][52][53]. Later, the enlargement or rupture of one or more Rich foci results in the development of different types of CNS TB (e.g., TBM, tuberculomas, and TB abscesses) [43,46,[48][49]52].…”

Section: Plos Onementioning

confidence: 99%

“…Later, the enlargement or rupture of one or more Rich foci results in the development of different types of CNS TB (e.g., TBM, tuberculomas, and TB abscesses) [43,46,[48][49]52]. The most common form of the disease is TBM that accounts for 70-80% of all cases with CNS TB [44,49]. TBM usually develops subsequent to the rupture of one or more meningeal, subpial, and/or subependymal caseating Rich foci into the subarachnoid space or into the ventricular system, both occupied by the cerebrospinal fluid (CSF) [43][44][45]49,[52][53][54][55][56].…”

Section: Plos Onementioning

confidence: 99%

“…The most common form of the disease is TBM that accounts for 70-80% of all cases with CNS TB [44,49]. TBM usually develops subsequent to the rupture of one or more meningeal, subpial, and/or subependymal caseating Rich foci into the subarachnoid space or into the ventricular system, both occupied by the cerebrospinal fluid (CSF) [43][44][45]49,[52][53][54][55][56]. The release of sufficient numbers of TB bacteria into the CSF triggers the onset of diffuse granulomatous inflammation of the leptomeninges (i.e., the pia and arachnoid mater), with a strong predilection for the basal areas of the brain [43][44][45]49,[52][53][54][55].…”

Section: Plos Onementioning

confidence: 99%

See 4 more Smart Citations

Tracking down the White Plague: The skeletal evidence of tuberculous meningitis in the Robert J. Terry Anatomical Skeletal Collection

et al. 2020

View full text Add to dashboard Cite

Paleopathological diagnosis of tuberculosis (TB) essentially relies on the identification of macroscopic lesions in the skeleton that can be related to different manifestations of TB. Among these alterations, granular impressions (GIs) on the inner skull surface have been considered as pathognomonic features of tuberculous meningitis (TBM). GIs may be established by pressure atrophy of the tubercles formed on the outermost meningeal layer during later stages of TBM. Although GIs were used as diagnostic criteria for TBM in the paleopathological practice since the late 20 th century, their diagnostic value has been questioned. To contribute to strengthening the diagnostic value of GIs, a macroscopic investigation-focusing on the macromorphological characteristics and frequency of GIs-was performed on skeletons of known cause of death from the Terry Collection. The χ 2 analysis of our data revealed that GIs were significantly more common in individuals who died of TB than in individuals who died of non-TB causes. Furthermore, GIs were localized on the inner surface of the skull base and of the lower lateral skull vault. The localization pattern and distribution of GIs on the endocranial surface resemble that of the tubercles observed in the affected meninges during the pathogenesis of TBM. Our results strengthen the tuberculous origin of GIs and imply that they can be considered as specific signs of TBM. Therefore, GIs can be used as diagnostic criteria for TBM in the paleopathological practice, and the diagnosis of TBM can be established with a high certainty when GIs are present in ancient human bone remains.

show abstract

Section: Plos Onementioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

See 3 more Smart Citations

Tracking down the White Plague: The skeletal evidence of tuberculous meningitis in the Robert J. Terry Anatomical Skeletal Collection

et al. 2020

View full text Add to dashboard Cite

show abstract

Oral Administration of Nanoparticles-Based TB Drugs

Magalhães

Vieira

Santos

et al. 2017

Multifunctional Systems for Combined Delivery, Biosensing and Diagnostics

View full text Add to dashboard Cite

Pulmonary Tuberculosis With Central Nervous System Streptococcus anginosus Coinfection in an Immunocompetent Man

Ata¹,

Sharma²,

Ibrahim

et al. 2020

Infectious Diseases in Clinical Practice

View full text Add to dashboard Cite

Tuberculosis (TB) is a ubiquitous disease occurring in every part of the globe. The central nervous system (CNS) involvement of TB has been a well-known complication with significant morbidity. Knowledge about TB and CNS bacterial coinfection is limited. We present a case of pulmonary TB and Streptococcus anginosus (SA) brain abscess in an immunocompetent middle-aged patient. This case presented with left upper and lower limb weakness and was found to have right-sided subdural empyema due to SA along with pulmonary TB. In cases of suspected CNS-TB, which develop neurological deterioration despite adequate treatment, an alternative microbiological diagnosis should be kept in the differentials. The CNS bacterial infections from the SA group occurring in concurrence with pulmonary TB can lead to severe complications. Timely neurosurgical intervention may be needed in such instances.

show abstract

Tuberculosis of The Central Nervous System

Cited by 6 publications

References 10 publications

Tracking down the White Plague: The skeletal evidence of tuberculous meningitis in the Robert J. Terry Anatomical Skeletal Collection

Tracking down the White Plague: The skeletal evidence of tuberculous meningitis in the Robert J. Terry Anatomical Skeletal Collection

Oral Administration of Nanoparticles-Based TB Drugs

Pulmonary Tuberculosis With Central Nervous System Streptococcus anginosus Coinfection in an Immunocompetent Man

Contact Info

Product

Resources

About