Tuberculosis Susceptibility Patterns, Predictors of Multidrug Resistance, and Implications for Initial Therapeutic Regimens at a New York City Hospital

Weltman, André; Rose, David N.

doi:10.1001/archinte.1994.00420190058007

Cited by 35 publications

(22 citation statements)

References 22 publications

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“…We matched cases and controls for gender and age bracket, considering that those variables could act as confusing factors, since the results found in the literature are rather discrepant regarding those two characteristics (21,22) .…”

Section: Resultsmentioning

confidence: 99%

“…The controversy started with the CDC publication on the MDR-TB outbreak among HIV-infected subjects in New York and Miami. Several investigators associated MDR-TB with HIV (22) , others showed that there was no association whatsoever (29,30) . In 1998, Spellman et al published a study conducted with the purpose of comparing the prevalence of MDR-TB among patients with and without HIV infection, to settle the matter; they concluded that HIV infection was not a risk factor for MDR-TB (31) .…”

Section: Resultsmentioning

confidence: 99%

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Risk factors for acquired multidrug-resistant tuberculosis

E¹,

Mota

Santos³

et al. 2003

J. Pneumologia

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Risk factors for acquired multidrug-resistant tuberculosis

E¹,

Mota

Santos³

et al. 2003

J. Pneumologia

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“…A study conducted in the United States discovered that HIV infection was also a risk factor for resistance [9][10][11][12][13]. Other risk factors reported included foreign birth, ethnicity, living in urban centers, and having cavitary pulmonary tuberculosis [9,11,[14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Multidrug-resistant tuberculosis and risk factors associated with its development: a retrospective study

Elmi

Hasan

Abdullah

et al. 2015

J Infect Dev Ctries

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Introduction: Multidrug-resistant tuberculosis (MDR-TB) has emerged as a major clinical public health threat and challenges the national TB control program in Malaysia. Data that elaborates on the risk factors associated with the development of MDR-TB is highly limited in this country. This study was aimed to determine the risk factors associated with the development of MDR-TB patients in peninsular Malaysia. Methodology: This was a case control study; the data were collected from medical records of all the registered MDR-TB patients at five referral TB hospitals in peninsular Malaysia from January 2010 to April 2014. The 105 cases were all confirmed by a positive sputum culture of Mycobacterium tuberculosis for MDR-TB and extensively drug-resistant (XDR)-TB. As a comparison, a total of 209 non-MDR-TB cases were randomly selected as controls. Results: A total of 105 MDR-TB and 209 non MDR-TB patients were studied. The risk factors associated with MDR-TB within the multivariate analysis were previous tuberculosis treatment, HIV infection, being an immigrant, and high load of positive for acid-fast bacillus (AFB) smear. Conclusions: The findings of this study revealed that patients who had received previous treatment for tuberculosis, were infected with HIV, were immigrants, and had a high burden of positive testing for AFB smear were more likely to have MDR-TB. An enhanced understanding of the risk factors associated with MDR-TB strains is imperative in the development of a national policy for public health interventions.

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“…HIV has been found to be a risk factor for resistance in the United States [5,[7][8][9] but not in Africa [10]. Some studies have found resistance to be associated with cavitatory pulmonary disease [11], and most studies from developed countries (particularly the United States) have found relationships with ethnic groupings [5,7], foreign birth [7,[12][13][14] and urban centres [13]. In the United Kingdom surveillance data from England and Wales have generally shown an excess of drug-resistant cases in London, in HIV-positive cases, those not born in the United Kingdom and sometimes in non-white ethnic groups [2,3,15].…”

Section: Introductionmentioning

confidence: 99%

Explaining risk factors for drug-resistant tuberculosis in England and Wales: contribution of primary and secondary drug resistance

Conaty

Hayward

Story³

et al. 2004

Epidemiol. Infect.

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Tuberculosis Susceptibility Patterns, Predictors of Multidrug Resistance, and Implications for Initial Therapeutic Regimens at a New York City Hospital

Abstract: Tuberculosis isolates at our hospital have a high frequency of multidrug resistance. Only five- or six-drug regimens are theoretically adequate as initial therapy for our patients.

Cited by 35 publications

References 22 publications

Risk factors for acquired multidrug-resistant tuberculosis

Risk factors for acquired multidrug-resistant tuberculosis

Multidrug-resistant tuberculosis and risk factors associated with its development: a retrospective study

Explaining risk factors for drug-resistant tuberculosis in England and Wales: contribution of primary and secondary drug resistance

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