Tuberculosis—The Great Mimicker

Prapruttam, Duangkamon; Hedgire, Sandeep; Mani, Sunithi; Chandramohan, Anuradha; Shyamkumar, NK; Harisinghani, Mukesh G.

doi:10.1053/j.sult.2014.02.002

Cited by 33 publications

(27 citation statements)

References 76 publications

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“…The diagnosis of skeletal TB is not a simple matter even today in a clinical setting (Aufderheide and Rodríguez Martin, 1998:133;Prapruttam et al, 2014;Ye et al, 2016), and is definitely challenging and prone to errors in a bioarchaeological setting (Wilbur et al, 2009;Roberts et al, 2009). An analysis based on dry bone must consider all possible diagnoses, and there are clearly lesions that may have been caused by both TB and other conditions in this skeleton.…”

Section: Differential Diagnosismentioning

confidence: 99%

“…Burrill et al, 2007;Singh et al, 2009;Harishingani et al, 2010;Prapruttam et al, 2014;Elmi et al, 2013;Ye et al, 2016). At this stage of the research, it is difficult to determine whether this was due to different strains of the pathogen infecting the person, an effect of the host's immune response, or to environmental factors shaping how the pathogen affected the bones.…”

Section: Significance For Bioarchaeology and Paleoepidemiology Of Tbmentioning

confidence: 99%

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A 6500-year-old Middle Neolithic child from Pollera Cave (Liguria, Italy) with probable multifocal osteoarticular tuberculosis

Sparacello

Roberts

Kerudin

et al. 2017

International Journal of Paleopathology

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Citation for published item: p r elloD it le F nd o ertsD gh rlotte eF nd uerudinD emmielle nd w¤ ullerD omy @PHIUA 9e TSHHEye rEold widdle xeolithi hild from oller g ve @viguri D st lyA with pro le multifo l osteo rti ul r tu er ulosisF9D sntern tion l journ l of p leop thologyFD IU F ppF TUEURF Further information on publisher's website: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details.

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Section: Differential Diagnosismentioning

confidence: 99%

Section: Significance For Bioarchaeology and Paleoepidemiology Of Tbmentioning

confidence: 99%

A 6500-year-old Middle Neolithic child from Pollera Cave (Liguria, Italy) with probable multifocal osteoarticular tuberculosis

Sparacello

Roberts

Kerudin

et al. 2017

International Journal of Paleopathology

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“…In TB lesions, however, a recent morphologic study demonstrated a sharp decrease in microvessel density from the granuloma edge to the avascular central region (16). The thin-rim enhancement pattern of TB lesions in enhanced CT images also confirms the low-angiogenesis feature that is different from NSCLC (7).…”

mentioning

confidence: 76%

“…Tuberculosis (TB), caused by Mycobacteria, infects one third of the world's population and often radiologically manifests like lung cancer (5)(6)(7). Such epidemic situations and radiographic features have made TB the unshakable leading cause of false-positive PET/CT lung cancer diagnoses in high-prevalence areas.…”

mentioning

confidence: 99%

Comparing the Diagnostic Potential of ⁶⁸Ga-Alfatide II and ¹⁸F-FDG in Differentiating Between Non–Small Cell Lung Cancer and Tuberculosis

et al. 2015

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The objectives of this study were to compare the diagnostic potential of 68 Ga-Alfatide II with 18 F-FDG in differentiating between non-small cell lung cancer patients (NSCLC) and lung tuberculosis (TB) patients. Methods: Twenty-one NSCLC patients and 13 TB patients were recruited. PET/CT images using either 68 Ga-Alfatide II or 18 F-FDG were acquired in 2 consecutive days. SUV quantitative comparison, receiver-operating curve analysis, and comprehensive visual analysis were performed. The expression of the angiogenesis marker α v β 3 in NSCLC and TB primary lesions was analyzed by immunohistochemistry. Results: The 68 Ga-Alfatide II SUV max and SUV mean were significantly different in NSCLC and TB (P 5 0.0001 and 0.0007, respectively). The area under the receiver-operating curve value of 68 Ga-Alfatide II SUV max was significantly higher than that of 18 F-FDG (P 5 0.038). The visual differentiation diagnostic specificity of 68 Ga-Alfatide II was 1.57-fold (84.62% vs. 53.85%) higher than that of 18 F-FDG. In the detection of NSCLC lymph nodes, 68 Ga-Alfatide II was superior in specificity (100% vs. 66.7%), whereas the sensitivity was greater with 18 F-FDG (87.5% vs. 75%). In TB lymph node detection, the false-positive rate of 68 Ga-Alfatide II was one-third (15.4%/ 46.2%) the value of 18 F-FDG. Additionally, 68 Ga-Alfatide II detected more metastases in the brain but less in the liver and the bone. The α v β 3 biomarker was specifically expressed in the cells and the neovasculature of NSCLC lesions. Conclusion: 68 Ga-Alfatide II is qualified for detecting NSCLC primary lesions and is superior to 18 F-FDG in distinguishing NSCLC from TB in primary lesions and suggestive lymph nodes. 68 Ga-Alfatide II is more likely to be capable of detecting brain metastasis, and 18 F-FDG is more likely to be capable of detecting liver and early-stage bone metastases.

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“…It may develop from reactivation of latent foci in the peritoneal cavity or from hematogenous spread from a primary pulmonary infection. Tuberculous peritonitis has been described in three form: 'wet type' with free or loculated ascites; 'dry or plastic type' with caseous nodules, fibrous peritoneal reaction and dense adhesions; and 'fibrotic fixed type' with mass formation of omentum and bowel loops with occasional loculated ascites [8]. Patients characterize with abdominal pain, weight loss, fever and insidious onset ascites.…”

Section: Female Genital and Peritoneal Tuberculosismentioning

confidence: 99%

Tuberculosis in Gynecologic Oncology: Still a Diagnostic Dilemma

Yardımcı¹,

Özgü²,

Öz³

et al. 2014

OGIJ

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Tuberculosis—The Great Mimicker

Cited by 33 publications

References 76 publications

A 6500-year-old Middle Neolithic child from Pollera Cave (Liguria, Italy) with probable multifocal osteoarticular tuberculosis

A 6500-year-old Middle Neolithic child from Pollera Cave (Liguria, Italy) with probable multifocal osteoarticular tuberculosis

Comparing the Diagnostic Potential of ⁶⁸Ga-Alfatide II and ¹⁸F-FDG in Differentiating Between Non–Small Cell Lung Cancer and Tuberculosis

Tuberculosis in Gynecologic Oncology: Still a Diagnostic Dilemma

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Tuberculosis—The Great Mimicker

Cited by 33 publications

References 76 publications

A 6500-year-old Middle Neolithic child from Pollera Cave (Liguria, Italy) with probable multifocal osteoarticular tuberculosis

A 6500-year-old Middle Neolithic child from Pollera Cave (Liguria, Italy) with probable multifocal osteoarticular tuberculosis

Comparing the Diagnostic Potential of 68Ga-Alfatide II and 18F-FDG in Differentiating Between Non–Small Cell Lung Cancer and Tuberculosis

Tuberculosis in Gynecologic Oncology: Still a Diagnostic Dilemma

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Comparing the Diagnostic Potential of ⁶⁸Ga-Alfatide II and ¹⁸F-FDG in Differentiating Between Non–Small Cell Lung Cancer and Tuberculosis