Tuberculosis transmission in a hospitalised neonate: Need for optimised tuberculosis screening of pregnant and postpartum women

Zenhäusern, J; Bekker, Adrie; Wates, M.; Schaaf, H. Simon; Dramowski, Angela

doi:10.7196/samj.2019.v109i5.13789

Cited by 4 publications

(4 citation statements)

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“…With appropriate treatment and close follow-up, pregnant women sick with TB can be cured and have positive maternal outcomes. Integration of TB screening programs with maternal care services could be an efficient way to detect cases in women that might otherwise remain undetected, as most TB in pregnancy is diagnosed in the third trimester of pregnancy or in the postpartum period [3,4,22,23]. Another 2017 systematic review and meta-analysis including 13 studies found that TB disease in pregnancy is associated with adverse maternal and perinatal outcomes [7].…”

Section: Discussionmentioning

confidence: 99%

Tuberculosis clinical presentation and treatment outcomes in pregnancy: a prospective cohort study

et al. 2020

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Background There is limited research to guide TB treatment specifically in pregnant women and few studies have described the presentation of TB in pregnant women. We aimed to understand TB presentation and treatment outcomes in pregnant women in a low HIV burden setting. We describe a cohort of women of childbearing age treated for TB disease in Lima, Peru, and compare clinical presentation and treatment outcomes among pregnant and non-pregnant women between 2009 and 2012, including 36 pregnant women. Methods This is a prospective cohort study. Subjects were recruited from across 106 public health centers in Lima, Peru. Baseline demographic, medical history, and drug-susceptibility test results were collected. We used descriptive statistics to describe demographic and clinical characteristics of the women using Pearson chi-squared, Fisher’s exact tests, or Kruskal-Wallis. Results Among 4500 individuals with pulmonary TB disease, 1334 women were included in analysis with 36 (2.69%) pregnant women. Pregnant women had similar demographics, past medical histories, and clinical presentation to non-pregnant women, except being more likely to be married (p = 0.01) and have cardiac disease (p = 0.04) and less likely to have weight loss (p = 0.05). Twenty (71.4%) pregnant women had pan-susceptible TB compared with 616 (63.1%) non-pregnant women; four (14.3%) pregnant women had mono-resistant TB compared with 154 (15.8%) non-pregnant women; and four (14.3%) pregnant women had multi-drug-resistant TB compared with 140 (14.3%) of non-pregnant women (p = 0.53). Twenty-eight (96.6%) pregnant women had a successful outcome (cure, completed treatment, treatment ended early by clinical team) while one (3.4%) had an unsuccessful outcome (treatment failed) and 1074 (97.3%) non-pregnant women had a successful outcome while 30 (2.7%) had an unsuccessful outcome (p = 0.56). Conclusion In this cohort with low HIV co-infection, we found high TB treatment success rates in both pregnant and non-pregnant women, irrespective of drug-susceptibility profiles. If treated appropriately, pregnant women with TB disease can have successful outcomes.

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Section: Discussionmentioning

confidence: 99%

Tuberculosis clinical presentation and treatment outcomes in pregnancy: a prospective cohort study

et al. 2020

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“…This includes preeclampsia, intrauterine growth delay, prenatal bleeding, low birth weight, low Apgar score at birth, and early fetal death. 22 , 23 Early treatment can reverse this negative effect on perinatal outcomes. Late diagnosis and incomplete or partial pharmacotherapy are associated with poor outcomes.…”

Section: Discussionmentioning

confidence: 99%

Disseminated Hematogenous Tuberculosis Following in vitro Fertilization-Embryo Transfer: A Case Report

Ma¹,

Sun²,

Zhang³

et al. 2021

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“…Care units, to prevent exposure and transmission of TB to vulnerable neonates, mothers and healthcare workers. [20]…”

Section: In Practicementioning

confidence: 99%

Hospital-based evaluation of tuberculosis-exposed neonates: An approach to complement the South African national guidance

et al. 2021

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Tuberculosis transmission in a hospitalised neonate: Need for optimised tuberculosis screening of pregnant and postpartum women

Abstract: This open-access article is distributed under Creative Commons licence CC-BY-NC 4.0.

Cited by 4 publications

References 25 publications

Tuberculosis clinical presentation and treatment outcomes in pregnancy: a prospective cohort study

Tuberculosis clinical presentation and treatment outcomes in pregnancy: a prospective cohort study

Disseminated Hematogenous Tuberculosis Following in vitro Fertilization-Embryo Transfer: A Case Report

Hospital-based evaluation of tuberculosis-exposed neonates: An approach to complement the South African national guidance

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