Tuberculosis treatment and resulting abnormal blood glucose: a scoping review of studies from 1981 - 2021

Williams, Victor; Onwuchekwa, Chukwuemeka; Vos, Antonie; Grobbee, Diederick E.; Otwombe, Kennedy; Klipstein‐Grobusch, Kerstin

doi:10.1080/16549716.2022.2114146

Cited by 4 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TB-DM comorbidity is attributed to excessive and prolonged inflammation and organ damage and morbidity/mortality in pulmonary TB largely reflects the consequences of immune-mediated lung damage ( Ravimohan et al., 2018 ). Hyperglycaemic patients are likely to develop cavitary lung lesions and poor treatment outcomes with higher post-treatment mortality ( Williams et al., 2022 ). In fact, diabetic patients were found to develop more frequent lung cavities and parenchymal lesions upon chest X-ray ( Chiang et al., 2014 ).…”

Section: Impact Of Diabetes On the Susceptibility To Tuberculosismentioning

confidence: 99%

The cause–effect relation of tuberculosis on incidence of diabetes mellitus

Bisht

Dahiya

Ghosh

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Tuberculosis (TB) is one of the oldest human diseases and is one of the major causes of mortality and morbidity across the Globe. Mycobacterium tuberculosis (Mtb), the causal agent of TB is one of the most successful pathogens known to mankind. Malnutrition, smoking, co-infection with other pathogens like human immunodeficiency virus (HIV), or conditions like diabetes further aggravate the tuberculosis pathogenesis. The association between type 2 diabetes mellitus (DM) and tuberculosis is well known and the immune-metabolic changes during diabetes are known to cause increased susceptibility to tuberculosis. Many epidemiological studies suggest the occurrence of hyperglycemia during active TB leading to impaired glucose tolerance and insulin resistance. However, the mechanisms underlying these effects is not well understood. In this review, we have described possible causal factors like inflammation, host metabolic changes triggered by tuberculosis that could contribute to the development of insulin resistance and type 2 diabetes. We have also discussed therapeutic management of type 2 diabetes during TB, which may help in designing future strategies to cope with TB-DM cases.

show abstract

Section: Impact Of Diabetes On the Susceptibility To Tuberculosismentioning

confidence: 99%

The cause–effect relation of tuberculosis on incidence of diabetes mellitus

Bisht

Dahiya

Ghosh

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Previous studies did not estimate the proportion of SH among patients with newly diagnosed TB [ 10 ]. Various studies from Iran [ 11 ], Pakistan [ 12 ], and Tanzania [ 6 ] have, however, reported that more than half of patients with TB and newly diagnosed hyperglycemia achieved normoglycemia after three to six months of TB treatment [ 13 ]. Regardless of its cause, hyperglycemia needs to be treated.…”

Section: Introductionmentioning

confidence: 99%

Quantum of Stress Hyperglycemia at the Time of Initial Diagnosis of Tuberculosis

Tarachandani¹,

Singhal²,

Goyal³

et al. 2023

Cureus

View full text Add to dashboard Cite

BackgroundIndia has a high burden of both tuberculosis (TB) and diabetes mellitus (DM). The National TB Elimination Program recommends testing for glycemic status at the initiation of therapy; however, some individuals with elevated sugar levels might have stress hyperglycemia (SH) instead of true DM. Our aim was to perform a longitudinal glycemic assessment of individuals with TB to identify those with true newly diagnosed DM and those with SH. MethodsWe identified newly diagnosed adults with TB and abstracted information about demography, comorbidities, disease severity, and glucose-lowering agents. A glycemic assessment was performed at baseline and at the end of six months. ResultsWe included 150 patients with TB, and based on their initial HbA1c values, 82 (54.6%, 95% CI: 46-62%) had dysglycemia (30% had HbA1c levels above 6.4% and 24.6% had values between 5.9% and 6.4%) and 31 (20.7%, 95% CI: 14-18%) had SH. Among individuals with both baseline and follow-up glycemic values, 30% of the individuals previously defined as DM were characterized as SH. The proportion of true SH was 43% (95% CI: 33-60%). ConclusionMost individuals who have dysglycemia at the time of their TB diagnosis have SH. A close follow-up of such individuals will identify those who really require long-term glucose-lowering therapy.

show abstract

“…For example, the development of hyperglycemia because of first-line drugs against TB is an important risk factor for the severity of the disease. 20 It is also relevant to mention the liver injury induced by anti-tuberculosis drugs that considerably alters the concentration of liver and lipid metabolites, proving to be early prediction markers for this type of injury, avoiding complicating the health status of patients. 21 In this way, the measurement of the glucose, lipid, and liver profiles is relevant; its usefulness lies in the early identification of cases of asymptomatic patients who could develop biochemical alterations of the metabolites due to anti-tuberculosis treatment associated with the presence of the COVID-19 virus, and that this may lead to a possible deterioration in the quality of life of the patient.…”

Section: Introductionmentioning

confidence: 99%

Metabolic disorders in patients with post-COVID-19 Tuberculosis: A Peruvian unicentric experience

Cruz-Gonzales,

Hurtado-Concha,

Lezama-Cotrina

et al. 2023

F1000Res

View full text Add to dashboard Cite

Background: During the COVID-19 pandemic, the diagnosis, monitoring, and prevention of many significant pathologies began to be ignored, tuberculosis (TB) being one of these pathologies. The objective was to determine metabolic disorders and their association with TB stages in post-COVID-19 TB patients from the Félix Torrealva Gutiérrez Hospital in Ica, Peru. Methods: The research was observational, cross-sectional, and descriptive-correlational. The study was carried out on 80 patients diagnosed with post-COVID-19 tuberculosis. A questionnaire was used to collect the sociodemographic characteristics and the metabolites analyzed were glucose, lipid profile, and hepatic profile. Results: Among the 80 patients, a mean age of 56.6 years was observed and 52.5% were male. The presence of sensitive tuberculosis (56.3%), multiresistant tuberculosis (15%), and recurrent tuberculosis (28.7%) with 5.94 months of treatment was found. Alterations were found in the concentration of glucose (36.3%), total cholesterol (31.3%), triglycerides (52.5%), HDL (52.5%), LDL (53.8%), albumin (32.5%), total bilirubin (46.3%), direct bilirubin (5.0%), TGO (30.0%), TGP (56.3%), alkaline phosphatase (50.0%), GGTP (46.3%) and total protein (22.5%). TB stage was significantly associated with sex (p=0.011), treatment time (p˂0.001) and total cholesterol (p=0.021). Conclusions: There are post-COVID-19 metabolic disorders in patients with tuberculosis at the Félix Torrealva Gutiérrez Hospital in Ica, Peru.

show abstract

Tuberculosis treatment and resulting abnormal blood glucose: a scoping review of studies from 1981 - 2021

Cited by 4 publications

References 37 publications

The cause–effect relation of tuberculosis on incidence of diabetes mellitus

The cause–effect relation of tuberculosis on incidence of diabetes mellitus

Quantum of Stress Hyperglycemia at the Time of Initial Diagnosis of Tuberculosis

Metabolic disorders in patients with post-COVID-19 Tuberculosis: A Peruvian unicentric experience

Contact Info

Product

Resources

About