Tuberculous meningitis due to <i>Mycobacterium bovis</i>: a report of two cases

Wilkins, E.G.L.; Griffiths, R.; Roberts, C.; Green, H. T.

doi:10.1136/pgmj.62.729.653

Cited by 6 publications

(3 citation statements)

References 13 publications

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“…Humans with encephalic tuberculosis may present high lymphocyte cellular population in the liquor cytology; however, in the cases in which the infection is in the initial phase, neutrophils in greater quantity may be visualized (Coutinho & Tarragô 1976, Rock et al 2008. Besides the evaluation of the inflammatory cells present in the liquor, the Ziehl-Neelsen technique can be performed to observe the agent in the cerebrospinal fluid, though the absence of bacillus does not imply in the exclusion of the disease (Wilkins et al 1986).…”

Section: Discussionmentioning

confidence: 99%

Tuberculosis of the central nervous system in cattle in Paraíba, Brazil

et al. 2018

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This paper describes six cases of tuberculosis in the central nervous system (CNS) of cattle in the state of Paraíba in northeastern Brazil. We reviewed the autopsy reports of 851 bovine necropsies performed from 2003 to 2016. Seventy-three (8.6%) cattle were diagnosed with tuberculosis and six showed lesions in the CNS. Three cases affected cattle up to two-year-old and other three affected adults. Three cattle presented exclusively nervous signs, two had respiratory signs and weight loss and one did not present any clinical signs. At necropsy, five cattle had thickening of the leptomeninges of the cerebellum, pons, obex, spinal cord and cortex, mainly, in the region near the brain basilar Willis´ circle. Another animal, presented a single focal lesion in the cerebellum. Microscopically we observed moderate to severe granulomatous meningitis and encephalitis. Five cattle presented lesions in the lungs and mediastinal lymph nodes and three of them had disseminated lesions in other organs. In all cattle acid-fast bacilli were observed in the lesions and marked positive for immunohistochemistry with polyclonal antibody anti-Mycobacterium tuberculosis. It is concluded that bovine tuberculosis of central nervous system occurs sporadically in Paraíba, in cattle of different ages, most of them with disseminate lesions in other organs. The location of the lesions suggests that the agent invaded the brain by hematogenous route through the circle of Willis.

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Section: Discussionmentioning

confidence: 99%

Tuberculosis of the central nervous system in cattle in Paraíba, Brazil

et al. 2018

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“…M bovis meningitis has been reported in human beings (Jones and Silva 1982, Wilkins and others 1986, Norton and others 1995), but the pathogenesis of this complication of TB in man is poorly understood (Tsenova and others 1999). In cattle there are few reports of similar complications (Hartley 1974).…”

Section: Figurementioning

confidence: 99%

Mycobacterium bovis meningitis in a cow with clinical signs of BSE

et al. 2003

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“…Tuberculosis in humans is chiefly caused by Mycobacterium tuberculosis ( M. tb ). However, Mycobacterium bovis ( M. bovis ), the major tuberculosis pathogen in cattle, also causes disease in humans and is usually implicated in extrapulmonary tuberculosis (Wilkins et al ., 1986). Other members of the M. tb complex (MTC), such as M. bovis BCG (BCG), Mycobacterium africanum and Mycobacterium microti , rarely cause disease in immunocompromised populations (Metchock et al ., 1999; Niemann et al ., 2000).…”

Section: Introductionmentioning

confidence: 99%

A single-nucleotide mutation in the −10 promoter region inactivates thenarK2Xpromoter inMycobacterium bovisandMycobacterium bovisBCG and has an application in diagnosis

Chauhan

Singh

Tyagi

2010

FEMS Microbiology Letters

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Nitrate reduction is believed to be vital for the survival of tubercle bacteria under hypoxic/anaerobic conditions that are thought to prevail within granulomas. Nitrate reductase activity is rapidly induced in Mycobacterium tuberculosis (M. tb) under hypoxic conditions and is attributed to the induced expression of the nitrate/nitrite transporter gene, narK2. By contrast, Mycobacterium bovis (M. bovis) and M. bovis BCG (BCG) do not support the hypoxic induction of either nitrate reductase activity or narK2. Here, we show that the induction defect in the narK2X operon in M. bovis and BCG is caused by a -6T/C single nucleotide polymorphism (SNP) in the -10 promoter element essential for narK2X promoter activity. Complementation of M. bovis with both narGHJI and narK2X genes from M. tb failed to restore nitrate reductase activity in M. bovis, suggesting the involvement of additional genes/regulatory mechanisms for nitrate reduction that are absent in M. bovis. The -6T/C promoter-linked SNP enabled clear differentiation of M. tb from the other members of the M. tb complex, including M. bovis, BCG, Mycobacterium africanum and Mycobacterium microti, through a PCR-RFLP assay.

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Tuberculous meningitis due to Mycobacterium bovis: a report of two cases

Cited by 6 publications

References 13 publications

Tuberculosis of the central nervous system in cattle in Paraíba, Brazil

Tuberculosis of the central nervous system in cattle in Paraíba, Brazil

Mycobacterium bovis meningitis in a cow with clinical signs of BSE

A single-nucleotide mutation in the −10 promoter region inactivates thenarK2Xpromoter inMycobacterium bovisandMycobacterium bovisBCG and has an application in diagnosis

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